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Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells (2025)
Journal Article
Citro, V., Clerici, M., Della Porta, G., Maffulli, N., Boccaccini, A. R., Dale, T. P., & Forsyth, N. R. (2025). Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells. Stem Cells International, 2025, Article 9047956. https://doi.org/10.1155/sci/9047956

Tendon tissue engineering draws on regenerative medicine principles, offering innovative solutions to address the challenges posed by tendon injuries and degenerative conditions. Tendons’ inherent limited regenerative capacity often hinders complete... Read More about Tenogenic Cues Are Biochemically and Environmentally Distinct for Tendon Stem Cells and Mesenchymal/Stromal Stem Cells.

Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering (2025)
Journal Article
Citro, V., Clerici, M., Shephard, M. T., Dale, T. P., Boccaccini, A. R., & Forsyth, N. R. (2025). Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering. Advanced Materials Technologies, Article 2500246. https://doi.org/10.1002/admt.202500246

This study develops a biomaterial‐based strategy to address challenges in controlled growth factor delivery for tenogenic differentiation of mesenchymal stromal cells (MSCs) and tendon stem cells (TSCs). The 20% polycaprolactone (PCL) fibres, electro... Read More about Growth Factor‐Loaded Mesoporous Silica Particles, Incorporated in Electrospun PCL Fibres, Provide Topographical and Chemical Cues for Tendon Tissue Engineering.

Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture (2025)
Journal Article
Clerici, M., Camilla Ciardulli, M., Pavel Lamparelli, E., Lovecchio, J., Giordano, E., Dale, T. P., Forsyth, N. R., Maffulli, N., & Della Porta, G. (2025). Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture. Artificial Cells, Nanomedicine, and Biotechnology, 53(1), 1-16. https://doi.org/10.1080/21691401.2025.2475099

Tendon injuries significantly impact quality of life, prompting the exploration of innovative solutions beyond conventional surgery. Extracellular Vesicles (EVs) have emerged as a promising strategy to enhance tendon regeneration. In this study, huma... Read More about Human tendon stem/progenitor cell-derived extracellular vesicle production promoted by dynamic culture.

MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation (2024)
Journal Article
Al Saihati, H. A., Dessouky, A. A., Salim, R. F., Elgohary, I., El-Sherbiny, M., Ali, F. E. M., Moustafa, M. M. A., Shaheen, D., Forsyth, N. R., Badr, O. A., & Ebrahim, N. (in press). MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation. Stem Cell Research and Therapy, 15(1), 1-22. https://doi.org/10.1186/s13287-024-03889-9

Background: Coronavirus disease 2019 (COVID-19) has created a global pandemic with significant morbidity and mortality. SARS-CoV-2 primarily infects the lungs and is associated with various organ complications. Therapeutic approaches to combat COVID-... Read More about MSC–extracellular vesicle microRNAs target host cell-entry receptors in COVID-19: in silico modeling for in vivo validation.

A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration. (2024)
Journal Article
Younus, Z. M., Ahmed, I., Roach, P., & Forsyth, N. R. (in press). A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration. Biomaterials and Biosystems, 15, Article 100099. https://doi.org/10.1016/j.bbiosy.2024.100099

The bone-cartilage interface is defined by a unique arrangement of cells and tissue matrix. Injury to the interface can contribute to the development of arthritic joint disease. Attempts to repair osteochondral damage through clinical trials have gen... Read More about A phosphate glass reinforced composite acrylamide gradient scaffold for osteochondral interface regeneration..

Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. (2024)
Journal Article
Ebrahim, N., Al Saihati, H. A., Alali, Z., Aleniz, F. Q., Mahmoud, S. Y. M., Badr, O. A., Dessouky, A. A., Mostafa, O., Hussien, N. I., Farid, A. S., El-Sherbiny, M., Salim, R. F., Forsyth, N. R., Ali, F. E. M., & Alsabeelah, N. F. (2024). Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway. Biomedicine and Pharmacotherapy, 176, Article 116836. https://doi.org/10.1016/j.biopha.2024.116836

Alzheimer's disease (AD) is a devastating neurological condition characterized by cognitive decline, motor coordination impairment, and amyloid plaque accumulation. The underlying molecular mechanisms involve oxidative stress, inflammation, and neuro... Read More about Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway..

Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering (2024)
Journal Article
Vikranth, T., Dale, T., & Forsyth, N. R. (2024). Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering. Journal of Tissue Engineering and Regenerative Medicine, 2024, https://doi.org/10.1155/2024/9940673

Persistent air leaks caused by thoracic surgery, physical trauma, or spontaneous pneumothoraces are a cause of patient morbidity with need for extended chest tube durations and surgical interventions. Current treatment measures involve mechanical clo... Read More about Decellularisation and Characterisation of Porcine Pleura as Bioscaffolds in Tissue Engineering.

Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers (2024)
Journal Article
Diaz, F., Zimmermann, L., Dale, T. P., Forsyth, N. R., & Boccaccini, A. R. (2024). Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers. Carbohydrate Polymer Technologies and Applications, 7, Article 100447. https://doi.org/10.1016/j.carpta.2024.100447

Rotator cuff injuries affect a large percentage of the population worldwide. Surgical repair has rates of failure of up to 70%, and existing materials used in the reinforcement of injuries often lack appropriate mechanical properties and biodegradabi... Read More about Tuning the properties of all natural polymeric scaffolds for tendon repair with cellulose microfibers.

TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity (2024)
Journal Article
Dogan, F., & Forsyth, N. R. (in press). TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity. Biomolecules, 14(1), Article 131. https://doi.org/10.3390/biom14010131

Telomere repeats protect linear chromosomes from degradation, and telomerase has a prominent role in their maintenance. Telomerase has telomere-independent effects on cell proliferation, DNA replication, differentiation, and tumorigenesis. TERT (telo... Read More about TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity.

A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION (2024)
Presentation / Conference Contribution
Clerici, M., Ciardulli, M., Forsyth, N., Maffulli, N., & Della Porta, G. (2023, September). A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION. Presented at The European Orthopaedic Research Society (EORS) 31st Annual Meeting, Porto, Portugal

Tendon injuries are a common problem that can significantly impact an individual's quality of life. While traditional surgical methods have been used to address this issue, Extracellular Vesicles (EVs) have emerged as a promising approach to promote... Read More about A ROLE FOR PERFUSION-DELIVERED SHEAR FORCE IN THE PROMOTION OF TPSC EV PRODUCTION.

Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration (2023)
Journal Article
Atwal, A., Dale, T. P., Snow, M., Forsyth, N. R., & Davoodi, P. (2023). Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration. Advances in colloid and interface science, 321, Article 103030. https://doi.org/10.1016/j.cis.2023.103030

The impairment of articular cartilage due to traumatic incidents or osteoarthritis has posed significant challenges for healthcare practitioners, researchers, and individuals suffering from these conditions. Due to the absence of an approved treatmen... Read More about Injectable hydrogels: An emerging therapeutic strategy for cartilage regeneration.

Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential (2023)
Journal Article
Clerici, M., Citro, V., Byrne, A. L., P. Dale, T., Boccaccini, A. R., Della Porta, G., Maffulli, N., & Forsyth, N. R. (2023). Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential. International Journal of Molecular Sciences, 24(20), Article 15107. https://doi.org/10.3390/ijms242015107

Tendon injuries caused by overuse or age-related deterioration are frequent. Incomplete knowledge of somatic tendon cell biology and their progenitors has hindered interventions for the effective repair of injured tendons. Here, we sought to compare... Read More about Endotenon-Derived Type II Tendon Stem Cells Have Enhanced Proliferative and Tenogenic Potential.

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair (2023)
Journal Article
Citro, V., Clerici, M., Boccaccini, A. R., Della Porta, G., Maffulli, N., & Forsyth, N. R. (2023). Tendon tissue engineering: An overview of biologics to promote tendon healing and repair. Journal of Tissue Engineering,

Tendons are dense connective tissues with a hierarchical polarized structure that respond to and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion and maintaining posture. Tendon injuries, also known as tendinopa... Read More about Tendon tissue engineering: An overview of biologics to promote tendon healing and repair.

The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner (2023)
Preprint / Working Paper
Shephard, M. T., Merkhan, M. M., Dale, T. P., & Forsyth, N. R. (2023). The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner

Background
Chronic disease states can share inflammation as an underlying pathology. Macrophages are associated with chronic inflammation; in general, M1 phenotype macrophage activity inhibits cell proliferation and causes tissue damage whilst M2 ma... Read More about The Human Mesenchymal Stem Cell Secretome Directs Macrophage Differentiation in an Oxygen-Dependent Manner.

Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro (2023)
Journal Article
Dale, T. P., Santer, M. D., Haris, M., Zuo, W., & Forsyth, N. R. (2023). Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro. Experimental Lung Research, 49(1), 12-26. https://doi.org/10.1080/01902148.2022.2158404

PURPOSE: Chronic obstructive pulmonary disease (COPD) patients experience hypoxemia and lung tissue hypoxia, causing vasoconstriction, and at its most severe Cor pulmonale. However, minimal attention has been given to the effects of hypoxia at the ce... Read More about Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro.

Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent (2022)
Journal Article
Shephard, M., Merkhan, M., & Forsyth, N. (2022). Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent. International Journal of Molecular Sciences, https://doi.org/10.3390/ijms232113596

The Human Mesenchymal Stem Cell (hMSC) secretome has pleiotropic effects underpinning its therapeutic potential. hMSC serum-free conditioned media (SFCM) contains a variety of cytokines, with previous studies linking a changed secretome composition t... Read More about Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.