The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents

Mbye, H; Richardson, A; Li, W; Horrocks, P; Johnson-Ajinwo, O; Ullah, I

doi:10.1016/j.bmcl.2018.02.051

All Outputs (4)

Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. (2018)
Journal Article
Price, H., Berry, S., Hameed, H., Thomason, A., Maciej-Hulme, M., Saif Abou-Akkada, S., & Horrocks, P. (2018). Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays. PLoS Neglected Tropical Diseases, 12(7), Article e0006639 . https://doi.org/10.1371/journal.pntd.0006639

The protozoan parasite Leishmania causes leishmaniasis; a spectrum of diseases of which there are an estimated 1 million new cases each year. Current treatments are toxic, expensive, difficult to administer, and resistance to them is emerging. New th... Read More about Development of NanoLuc-PEST expressing Leishmania mexicana as a new drug discovery tool for axenic- and intramacrophage-based assays..

Investigation of the antibiofilm capacity of peptide-modified stainless steel (2018)
Journal Article
Cao, P., Li, W., Morris, A. R., Horrocks, P. D., Yuan, C., & Yang, Y. (2018). Investigation of the antibiofilm capacity of peptide-modified stainless steel. Royal Society Open Science, https://doi.org/10.1098/rsos.172165

Biofilm formation on surfaces is an important research topic in ship tribology and medical implants. In this study, dopamine and two types of synthetic peptides were designed and attached to 304 stainless steel surfaces, aiming to inhibit the formati... Read More about Investigation of the antibiofilm capacity of peptide-modified stainless steel.

G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets (2018)
Journal Article
Horrocks. (2018). G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.01828-17

G-quadruplexes are DNA or RNA secondary structures that can be formed from guanine-rich nucleic acids. These four-stranded structures, composed of stacked quartets of guanine bases, can be highly stable and have been demonstrated to occur in vivo in... Read More about G-quadruplex DNA motifs in the malaria parasite Plasmodium falciparum and their potential as novel antimalarial drug targets.

The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents (2018)
Journal Article
Mbye, H., Richardson, A., Li, W., Horrocks, P., Johnson-Ajinwo, O., & Ullah, I. (2018). The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorganic and Medicinal Chemistry Letters, https://doi.org/10.1016/j.bmcl.2018.02.051

Thymoquinone (TQ), 2-isopropyl-5-methyl-1,4-benzoquinone, a natural product isolated from Nigella sativa L., has previously been demonstrated to exhibit antiproliferative activity in vitro against a range of cancers as well as the human malarial para... Read More about The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents.