All Outputs (6)

Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives (2013)
Journal Article
Horrocks, P., Pickard, M. R., Parekh, H. H., Patel, S. P., & Pathak, R. B. (2013). Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives. Organic and Biomolecular Chemistry, 11(29), 4891. https://doi.org/10.1039/c3ob27290g

3-(4-Chlorophenyl)-4-substituted pyrazole derivatives were synthesised and tested for their in vitro antifungal activity. Some compounds showed very good antifungal activity against four pathogenic strains of fungi. The same compounds exhibited an in... Read More about Synthesis and biological evaluation of 3-(4-chlorophenyl)-4-substituted pyrazole derivatives.

Analysis of the spatial and temporal arrangement of transcripts over intergenic regions in the human malarial parasite Plasmodium falciparum (2013)
Journal Article
Horrocks. (2013). Analysis of the spatial and temporal arrangement of transcripts over intergenic regions in the human malarial parasite Plasmodium falciparum. BMC Genomics, 267 - ?. https://doi.org/10.1186/1471-2164-14-267

BACKGROUND: The ability of the human malarial parasite Plasmodium falciparum to invade, colonise and multiply within diverse host environments, as well as to manifest its virulence within the human host, are activities tightly linked to the temporal... Read More about Analysis of the spatial and temporal arrangement of transcripts over intergenic regions in the human malarial parasite Plasmodium falciparum.

Functional analysis of the 5′ untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum (2013)
Journal Article
Hasenkamp, S., Russell, K., Ullah, I., & Horrocks, P. (2013). Functional analysis of the 5′ untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum. Acta tropica, 127(1), 69-74. https://doi.org/10.1016/j.actatropica.2013.03.007

Plasmodium falciparum transcripts contain long untranslated regions (UTR), with some of the longest in any eukaryote that uses monocistronic transcription. Owing to the extreme AT nucleotide bias within the intergenic regions that encode these UTR, a... Read More about Functional analysis of the 5′ untranslated region of the phosphoglutamase 2 transcript in Plasmodium falciparum.

Review of “Malaria parasites: comparative genomics, evolution and molecular biology” by Jane M. Carlton, Susan L. Perkins and Kirk W. Deitsch (2013)
Journal Article
Horrocks, P. (2013). Review of “Malaria parasites: comparative genomics, evolution and molecular biology” by Jane M. Carlton, Susan L. Perkins and Kirk W. Deitsch. Parasites and Vectors, 6(1), https://doi.org/10.1186/1756-3305-6-74

A quantitative analysis of Plasmodium falciparum transfection using DNA-loaded erythrocytes (2013)
Journal Article
Hasenkamp, S., Merrick, C. J., & Horrocks, P. (2013). A quantitative analysis of Plasmodium falciparum transfection using DNA-loaded erythrocytes. Molecular and Biochemical Parasitology, 187(2), 117-120. https://doi.org/10.1016/j.molbiopara.2013.01.001

Evaluation of bioluminescence-based assays of anti-malarial drug activity (2013)
Journal Article
Horrocks. (2013). Evaluation of bioluminescence-based assays of anti-malarial drug activity. Malaria Journal, 58 - ?. https://doi.org/10.1186/1475-2875-12-58

Transgenic Plasmodium falciparum expressing luciferase offers an attractive bioluminescence-based assay platform for the investigation of the pharmacological properties of anti-malarial drugs. Here a side-by-side comparison of bioluminescence and flu... Read More about Evaluation of bioluminescence-based assays of anti-malarial drug activity.