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Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis (2018)
Journal Article
Wong, C., Kwok, C., Narain, A., Gulati, M., Mihalidou, A., Wu, P., …Mamas, M. (2018). Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis. Heart, 1937-1948. https://doi.org/10.1136/heartjnl-2018-313005

Background The influence of marital status on the incidence of cardiovascular disease (CVD) and prognosis after CVD is inconclusive. We systematically reviewed the literature to determine how marital status influences CVD and prognosis after CVD.... Read More about Marital status and risk of cardiovascular diseases: A systematic review and meta-analysis.

Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. . L., Su, Y. . C., Feng, Y. . H., Huang, Y. . S., Wu, P., & Wu, C. . L. (2018, October). Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Poster presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell Research (ISSCR) and the French Society of Gene and Cell Therapy (SFTCG), Lausanne, Switzerland

The elongation of long-chain fatty acids family member 6(Elovl6), a key enzyme in lipogenesis, catalyzes the elongation of saturated and monounsaturated fatty acids. Insulin resistance is associated with upregulation of Elovl6, which has been linkedt... Read More about Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma.

Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. L., Su, Y. C., Feng, Y. H., Huang, Y. S., Wu, P., & Wu, C. L. (2018, October). Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Paper presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell Research (ISSCR) and the French Society of Gene and Cell Therapy (SFTCG), Lausanne, Switzerland

The Factor IX (FIX) gene therapy (BAX335) was produced in small-scale for hemophilia-B patients in clinical phase I/II. In the course of the internal BAX335 process development, the small-scale clinical product was compared to BAX335 developed using... Read More about Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma.

CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE (2018)
Presentation / Conference
Chen, L., Merkhan, M., Forsyth, N. R., & Wu, P. (2018, September). CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE. Poster presented at International Federation of Placenta Associations Meeting, Tokyo, Japan

Objectives: Chorionic and amniotic MSCs (CMSCs/AMSCs) are derived from different sides of placental membrane. Women with a history of gestational diabetes mellitus have a high risk of developing subsequent diabetes. As cell therapy is a promising... Read More about CHARACTERIZATION AND DIFFERENTIATION OF PLACENTA-DERIVED MESENCHYMAL STEM CELLS FROM GDM WOMEN INTO INSULIN PRODUCING CELLS FOR PERSONALISED MEDICINE.

Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression (2018)
Journal Article
Wu. (2018). Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression. Scientific reports, https://doi.org/10.1038/s41598-018-24633-3

The elongation of long-chain fatty acids family member 6 (Elovl6) is a key enzyme in lipogenesis that catalyzes the elongation of saturated and monounsaturated fatty acids. Insulin resistance involves upregulation of Elovl6, which has been linked to... Read More about Elovl6 is a negative clinical predictor for liver cancer and knockdown of Elovl6 reduces murine liver cancer progression.

Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis (2018)
Presentation / Conference
Wu, P., Gulati, M., Kwok, C., Wong, C., Narain, A., O'Brien, S., …Mamas, M. (2018, April). Preterm delivery and maternal cardiovascular disease future risk: A systematic review and meta-analysis. Poster presented at British Maternal & Fetal Medicine Society (BMFMS) 20th Annual Conference 2018, Brighton, UK

Objectives We aimed to systematically evaluate and summarise the evidence on the relationship between preterm birth (

Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies (2018)
Journal Article
Wu, P., Farrell, W., Haworth, K., Emes, R., Kitchen, M., Glossop, J., …Fryer, A. (2018). Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies. Epigenetics, 122-128. https://doi.org/10.1080/15592294.2016.1166321

Several recent reports have described associations between gestational diabetes (GDM) and changes to the epigenomic landscape where the DNA samples were derived from either cord or placental sources. We employed genome-wide 450K array analysis to det... Read More about Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies.