IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Almine, Jessica F.; O’Hare, Craig A.J.; Dunphy, Gillian; Haga, Ismar R.; Naik, Rangeetha J.; Atrih, Abdelmadjid; Connolly, Dympna J.; Taylor, Jordan; Kelsall, Ian R.; Bowie, Andrew G.; Beard, Philippa M.; Unterholzner, Leonie

doi:10.1038/ncomms14392

All Outputs (2)

Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales (2017)
Journal Article
Gupta, N., Noël, R., Goudet, A., Hinsinger, K., Michau, A., Pons, V., Abdelkafi, H., Secher, T., Shima, A., Shtanko, O., Sakurai, Y., Cojean, S., Pomel, S., Liévin-Le Moal, V., Leignel, V., Herweg, J.-A., Fischer, A., Johannes, L., Harrison, K., Beard, P. M., …Gillet, D. (2017). Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales. Chemico-Biological Interactions, 267, 96-103. https://doi.org/10.1016/j.cbi.2016.10.005

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes (2017)
Journal Article
Almine, J. F., O’Hare, C. A., Dunphy, G., Haga, I. R., Naik, R. J., Atrih, A., Connolly, D. J., Taylor, J., Kelsall, I. R., Bowie, A. G., Beard, P. M., & Unterholzner, L. (2017). IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes. Nature communications, 8, Article 14392. https://doi.org/10.1038/ncomms14392

<jats:title>Abstract</jats:title><jats:p>Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other put... Read More about IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes.