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All Outputs (14)

Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study (2025)
Journal Article
Hamad, N., Muller, S., Hider, S., Partington, R., Helliwell, T., Butt, H., Hay, C., & Mallen, C. (2025). Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study. Rheumatology Advances in Practice, 1-19. https://doi.org/10.1093/rap/rkaf060

Objectives
To investigate the anatomical locations of pain and stiffness in people with polymyalgia rheumatica (PMR) and how it compares to the general population.

Methods
739 people with PMR were invited to complete a postal survey at the time... Read More about Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study.

OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Adeniran, K., Partington, R., Bailey, J., Mallen, C. D., Muller, S., & Scott, I. C. (2025, April). OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum. Presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England

Background/Aims Fibromyalgia, a common condition characterised by chronic widespread pain/somatic symptoms, has substantial impacts on patients’ lives and healthcare use. Previous studies suggest it is far more common in inflammatory arthritis than t... Read More about OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum.

OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink (2025)
Presentation / Conference Contribution
Partington, R., Muller, S., Mallen, C. D., Mamas, M. A., Forrester, H., & Roddy, E. (2025, April). OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink. Presented at British Society for Rheumatology Annual Conference, Manchester Central Convention Complex, Manchester, England

Background/Aims Febuxostat is recommended as first line urate-lowering therapy (ULT) for gout in the UK. However, concerns were raised regarding its cardiovascular (CV) safety. Current guidance advises caution when using it in people with CV disease,... Read More about OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink.

P087 Cardioprotective effects of colchicine in people with gout: a systematic review (2025)
Presentation / Conference Contribution
Prior, J. A., Umar, Z., Ibrahim, N., Bajpai, R., Partington, R., Mamas, M., & Roddy, E. (2025, April). P087 Cardioprotective effects of colchicine in people with gout: a systematic review. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England UK

Background/Aims Colchicine is widely used in clinical practice to prevent and treat gout flares. Randomised controlled trials (RCT) have demonstrated cardiovascular benefits of colchicine in people with chronic coronary artery disease (CAD) or a rece... Read More about P087 Cardioprotective effects of colchicine in people with gout: a systematic review.

P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population (2024)
Presentation / Conference
Hammad, N., Partington, R., Hider, S., Butt, H., Helliwell, T., Mallen, C., & Muller, S. (2024, April). P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population. Poster presented at British Society for Rheumatology Annual Conference 2024

Background/Aims Polymyalgia rheumatica (PMR) is common in older adults, causing severe pain and stiffness, particularly in the shoulder and hip girdles. A tapered course of glucocorticoids is recommended, but not always straightforward, with frequent... Read More about P185 Anatomical patterns of pain in primary care patients with polymyalgia rheumatica compared to the general population.

Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study (2024)
Journal Article
Bajpai, R., Partington, R., Muller, S., Forrester, H., Mallen, C. D., Clarson, L., Padmanabhan, N., Whittle, R., & Roddy, E. (2024). Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study. Rheumatology, Article keae229. https://doi.org/10.1093/rheumatology/keae229

Objectives
Colchicine is commonly used to prevent flares when starting urate-lowering therapy for gout. Patients with gout are frequently concurrently prescribed other medications (such as statins) that may interact with colchicine, increasing the r... Read More about Prognostic factors for colchicine prophylaxis-related adverse events when initiating allopurinol for gout: retrospective cohort study.

Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink (2023)
Journal Article
Roddy, E., Bajpai, R., Forrester, H., James Partington, R., D Mallen, C., Clarson, L. E., Padmanabhan, N., Whittle, R., & Muller, S. (2023). Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, ard-2023-224154. https://doi.org/10.1136/ard-2023-224154

Objectives:
To determine the risk of adverse events associated with colchicine or non-steroidal anti-inflammatory drug (NSAID) prophylaxis when initiating allopurinol for gout.

Methods:
We conducted two matched retrospective cohort studies in... Read More about Safety of colchicine and NSAID prophylaxis when initiating urate-lowering therapy for gout: propensity score-matched cohort studies in the UK Clinical Practice Research Datalink.

P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies (2022)
Presentation / Conference Contribution
Roddy, E., Bajpai, R., Forrester, H., Partington, R., Mallen, C. D., Clarson, L., Padmanabhan, N., Whittle, R., & Muller, S. P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies

<jats:title>Abstract</jats:title> <jats:sec> <jats:title>Background/Aims</jats:title> <jats:p>Initiating urate-lowering therapy for gout commonly triggers a gout flare and hence co-prescription of colchicine or non-steroidal anti-inflammatory drug (N... Read More about P145 Safety of colchicine or NSAID prophylaxis when initiating allopurinol for gout: propensity score-matched cohort studies.

Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2021). Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study. Arthritis Care and Research, 73(12), 1853-1857. https://doi.org/10.1002/acr.24403

OBJECTIVE: To determine whether a diagnosis of polymyalgia rheumatica (PMR) is associated with premature mortality. METHODS: We extracted anonymised electronic medical records of patients over the age of 40 years, who were eligible for linkage with t... Read More about Mortality Among Patients With Polymyalgia Rheumatica: A Retrospective Cohort Study.

Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study (2020)
Journal Article
Partington, R., Muller, S., Mallen, C. D., Abdul Sultan, A., & Helliwell, T. (2020). Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study. Seminars in Arthritis and Rheumatism, 50(4), 663-672. https://doi.org/10.1016/j.semarthrit.2020.05.003

Objectives: To determine the burden of comorbidities, including glucocorticoid (GC) related adverse effects, in patients with polymyalgia rheumatica (PMR) before and after diagnosis.

Methods: We extracted anonymised electronic medical records of p... Read More about Comorbidities in patients with polymyalgia rheumatica prior to and following diagnosis: A case control and cohort study.

Comorbidities in polymyalgia rheumatica: a systematic review (2018)
Journal Article
Partington, R., Helliwell, T., Muller, S., Abdul Sultan, A., & Mallen, C. (2018). Comorbidities in polymyalgia rheumatica: a systematic review. Arthritis Research and Therapy, 258 -?. https://doi.org/10.1186/s13075-018-1757-y

BACKGROUND AND AIM: Comorbidities are known to exist in many rheumatological conditions. Polymyalgia rheumatica (PMR) is a common inflammatory rheumatological condition affecting older people which, prior to effective treatment, causes severe disabil... Read More about Comorbidities in polymyalgia rheumatica: a systematic review.

Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study (2018)
Journal Article
Partington, R., Muller, S., Helliwell, T., Mallen, C., & Abdul Sultan, A. (2018). Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study. Annals of the Rheumatic Diseases, 77(12), 1750-1756. https://doi.org/10.1136/annrheumdis-2018-213883

Objective
Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level... Read More about Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study.

The real evidence for polymyalgia rheumatica as a paraneoplastic syndrome. (2018)
Journal Article
Muller, S., Hider, S., Helliwell, T., Partington, R., & Mallen, C. (2018). The real evidence for polymyalgia rheumatica as a paraneoplastic syndrome. Reumatismo, 23 - 34. https://doi.org/10.4081/reumatismo.2018.1031

The aim of this study was to systematically consider the evidence for polymyalgia rheumatica (PMR) as a paraneoplastic disease. A systematic review of Medline and Embase was conducted from their inception to February 2017. Risk of bias was assessed u... Read More about The real evidence for polymyalgia rheumatica as a paraneoplastic syndrome..