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All Outputs (11)

Factors affecting the implementation of calcium supplementation strategies during pregnancy to prevent pre-eclampsia: a mixed-methods systematic review (2023)
Journal Article
Cormick, G., Moraa, H., Zahroh, R. I., Allotey, J., Rocha, T., Peña-Rosas, J. P., …Bohren, M. A. (2023). Factors affecting the implementation of calcium supplementation strategies during pregnancy to prevent pre-eclampsia: a mixed-methods systematic review. BMJ Open, 13(12), Article e070677. https://doi.org/10.1136/bmjopen-2022-070677

Objectives: Daily calcium supplements are recommended for pregnant women from 20 weeks’ gestation to prevent pre-eclampsia in populations with low dietary calcium intake. We aimed to improve understanding of barriers and facilitators for calcium supp... Read More about Factors affecting the implementation of calcium supplementation strategies during pregnancy to prevent pre-eclampsia: a mixed-methods systematic review.

Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. (2023)
Journal Article
Levis, B., Snell, K. I., Damen, J. A., Hattle, M., Ensor, J., Dhiman, P., …Riley, R. D. (in press). Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. Journal of Clinical Epidemiology, S0895-4356(23)00282-2. https://doi.org/10.1016/j.jclinepi.2023.10.022

Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We r... Read More about Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed..

Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies (2023)
Journal Article
Abhishek, A., Stevenson, M. D., Nakafero, G., Grainge, M. J., Evans, I., Alabas, O., …Williams, H. C. (2024). Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies. British Journal of Dermatology, 190(4), 559–564. https://doi.org/10.1093/bjd/ljad430

Background There is no evidence base to support the use of 6-monthly monitoring blood tests for the early detection of liver, blood and renal toxicity during established anti-tumour necrosis factor alpha (TNFα) treatment. Objectives To evaluate... Read More about Discontinuation of anti-tumour necrosis factor alpha treatment owing to blood test abnormalities, and cost-effectiveness of alternate blood monitoring strategies.

Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol (2023)
Journal Article
Stynes, S., Snell, K. I., Riley, R. D., Konstantinou, K., Cherrington, A., Daud, N., …Foster, N. E. (2023). Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol. BMJ Open, 13(11), Article e077776. https://doi.org/10.1136/bmjopen-2023-077776

Introduction: Sciatica can be very painful and, in most cases, is due to pressure on a spinal nerve root from a disc herniation with associated inflammation. For some patients, the pain persists, and one management option is a spinal epidural steroi... Read More about Predictors of outcome in sciatica patients following an epidural steroid injection: the POiSE prospective observational cohort study protocol.

Regularized parametric survival modeling to improve risk prediction models (2023)
Journal Article
Hoogland, J., Debray, T., Crowther, M., Riley, R., IntHout, J., Reitsma, J., & Zwinderman, A. (2024). Regularized parametric survival modeling to improve risk prediction models. Biometrical Journal, 66(1), Article 2200319

We propose to combine the benefits of flexible parametric survival modeling and regularization to improve risk prediction modeling in the context of time-to-event data. Thereto, we introduce ridge, lasso, elastic net, and group lasso penalties for bo... Read More about Regularized parametric survival modeling to improve risk prediction models.

Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects (2023)
Journal Article
Riley, R. D., Ensor, J., Hattle, M., Papadimitropoulou, K., & Morris, T. P. (in press). Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects. Research Synthesis Methods, 14(6), 903-910. https://doi.org/10.1002/jrsm.1661

Individual participant data meta‐analysis (IPDMA) projects obtain, check, harmonise and synthesise raw data from multiple studies. When undertaking the meta‐analysis, researchers must decide between a two‐stage or a one‐stage approach. In a two‐stage... Read More about Two‐stage or not two‐stage? That is the question for IPD meta‐analysis projects.

Vitamin D supplementation for improving bone density in vitamin D–deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials (2023)
Journal Article
Wu, F., El-Hajj Fuleihan, G., Cai, G., Lamberg-Allardt, C., Viljakainen, H. T., Rahme, M., …Winzenberg, T. (2023). Vitamin D supplementation for improving bone density in vitamin D–deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 118(3), 498-506. https://doi.org/10.1016/j.ajcnut.2023.05.028

Background Vitamin D supplements are widely used for improving bone health in children and adolescents, but their effects in vitamin D–deficient children are unclear. Objectives This study aimed to examine whether the effect of vitamin D supplem... Read More about Vitamin D supplementation for improving bone density in vitamin D–deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials.

Can prognostic factors for indirect muscle injuries in elite football (soccer) players be identified using data from preseason screening? An exploratory analysis using routinely collected periodic health examination records (2023)
Journal Article
Hughes, T., Riley, R., Callaghan, M. J., & Sergeant, J. C. (2023). Can prognostic factors for indirect muscle injuries in elite football (soccer) players be identified using data from preseason screening? An exploratory analysis using routinely collected periodic health examination records. BMJ Open, 13(1), Article e052772. https://doi.org/10.1136/bmjopen-2021-052772

Background: In elite football, periodic health examination (PHE) may be useful for injury risk prediction. Objective: To explore whether PHE-derived variables are prognostic factors for indirect muscle injuries (IMIs) in elite players. Design:... Read More about Can prognostic factors for indirect muscle injuries in elite football (soccer) players be identified using data from preseason screening? An exploratory analysis using routinely collected periodic health examination records.