All Outputs (7)

Calibration plots for multistate risk predictions models (2024)
Journal Article
Pate, A., Sperrin, M., Riley, R. D., Peek, N., Van Staa, T., Sergeant, J. C., …Martin, G. P. (in press). Calibration plots for multistate risk predictions models. Statistics in Medicine, https://doi.org/10.1002/sim.10094

Introduction There is currently no guidance on how to assess the calibration of multistate models used for risk prediction. We introduce several techniques that can be used to produce calibration plots for the transition probabilities of a multistat... Read More about Calibration plots for multistate risk predictions models.

Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials (2024)
Journal Article
Crocker, T. F., Jordão, M., Lam, N., Ramiz, R., Mirza, L., Patel, I., …Walford, R. (2024). Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials. Age and ageing, 53(5), 1-13. https://doi.org/10.1093/ageing/afae102

Introduction Community-based services to sustain independence for older people have varying configurations. A typology of these interventions would improve service provision and research by providing conceptual clarity and enabling the identification... Read More about Development of the Community-based complex Interventions to sustain Independence in Older People (CII-OP) typology: a qualitative synthesis of interventions in randomised controlled trials.

Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. (2024)
Journal Article
Archer, L., Relton, S. D., Akbari, A., Best, K., Bucknall, M., Conroy, S., …investigators, T. E. (2024). Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults. Age and ageing, 53(3), Article afae057. https://doi.org/10.1093/ageing/afae057

Falls are common in older adults and can devastate personal independence through injury such as fracture and fear of future falls. Methods to identify people for falls prevention interventions are currently limited, with high risks of bias in publish... Read More about Development and external validation of the eFalls tool: a multivariable prediction model for the risk of ED attendance or hospitalisation with a fall or fracture in older adults..

Community based complex interventions to sustain independence in older people: systematic review and network meta-analysis (2024)
Journal Article
Crocker, T. F., Ensor, J., Lam, N., Jordão, M., Bajpai, R., Bond, M., …Clegg, A. (2024). Community based complex interventions to sustain independence in older people: systematic review and network meta-analysis. BMJ, 384, Article e077764. https://doi.org/10.1136/bmj-2023-077764

To synthesise evidence of the effectiveness of community based complex interventions, grouped according to their intervention components, to sustain independence for older people. Systematic review and network meta-analysis. Medline, Embase, CINAHL,... Read More about Community based complex interventions to sustain independence in older people: systematic review and network meta-analysis.

Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation (2024)
Journal Article
Abhishek, A., Grainge, M., Card, T., Williams, H. C., Taal, M. W., Aithal, G. P., …Riley, R. (2024). Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation. RMD Open, 10(1), Article e003980. https://doi.org/10.1136/rmdopen-2023-003980

Background: Sulfasalazine-induced cytopenia, nephrotoxicity and hepatotoxicity is uncommon during long-term treatment. Some guidelines recommend 3 monthly monitoring blood tests indefinitely during long-term treatment while others recommend stopping... Read More about Risk-stratified monitoring for sulfasalazine toxicity: prognostic model development and validation.

Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data. (2024)
Journal Article
Wang, X., Li, Y., Shi, T., Bont, L. J., Chu, H. Y., Zar, H. J., …Nair, H. (in press). Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data. Lancet, 403(10433), 1241-1253. https://doi.org/10.1016/S0140-6736%2824%2900138-7

Infants and young children born prematurely are at high risk of severe acute lower respiratory infection (ALRI) caused by respiratory syncytial virus (RSV). In this study, we aimed to assess the global disease burden of and risk factors for RSV-assoc... Read More about Global disease burden of and risk factors for acute lower respiratory infections caused by respiratory syncytial virus in preterm infants and young children in 2019: a systematic review and meta-analysis of aggregated and individual participant data..

Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic review (2024)
Journal Article
Leaviss, J., Carroll, C., Essat, M., van der Windt, D., J Grainge, M., Card, T., …Abhishek, A. (2024). Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic review. RMD Open, 10(1), Article e003588. https://doi.org/10.1136/rmdopen-2023-003588

Background Immune-suppressing drugs can cause liver, kidney or blood toxicity. Prognostic factors for these adverse-events are poorly understood. Purpose To ascertain prognostic factors associated with liver, blood or kidney adverse-events in peop... Read More about Prognostic factors for liver, blood and kidney adverse events from glucocorticoid sparing immune-suppressing drugs in immune-mediated inflammatory diseases: a prognostic systematic review.