All Outputs (5)

A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae (2020)
Journal Article
Simoni, A., Hammond, A. M., Beaghton, A. K., Galizi, R., Taxiarchi, C., Kyrou, K., …Crisanti, A. (2020). A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Nature Biotechnology, https://doi.org/10.1038/s41587-020-0508-1

Only female insects transmit diseases such as malaria, dengue and Zika; therefore, control methods that bias the sex ratio of insect offspring have long been sought. Genetic elements such as sex-chromosome drives can distort sex ratios to produce uni... Read More about A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae.

Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies (2020)
Journal Article
Matos Rocha, E., de Melo Katak, R., Campos de Oliveira, J., da Silva Araujo, M., Cechetto Carlos, B., Galizi, R., …A. Souza-Neto, J. (2020). Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies. Tropical Medicine and Infectious Disease, 161. https://doi.org/10.3390/tropicalmed5040161

In Brazil, malaria transmission is mostly confined to the Amazon, where substantial progress has been achieved towards disease control in the past decade. Vector control has been historically considered a fundamental part of the main malaria control... Read More about Vector-Focused Approaches to Curb Malaria Transmission in the Brazilian Amazon: An Overview of Current and Future Challenges and Strategies.

Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics (2020)
Journal Article
Galizi, R., Duncan, J. N., Rostain, W., Quinn, C. M., Storch, M., Kushwaha, M., & Jaramillo, A. (2020). Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics. The CRISPR Journal, 398 - 408. https://doi.org/10.1089/crispr.2020.0029

CRISPR guide RNAs (gRNAs) can be programmed with relative ease to allow the genetic editing of nearly any DNA or RNA sequence. Here, we propose novel molecular architectures to achieve RNA-dependent modulation of CRISPR activity in response to specif... Read More about Engineered RNA-Interacting CRISPR Guide RNAs for Genetic Sensing and Diagnostics.

Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline (2020)
Journal Article
Elaine Haghighat-Khah, R., Sharma, A., Reis Wunderlich, M., Morselli, G., Anna Marston, L., Bamikole, C., …Galizi, R. (2020). Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline. Pathogens and Global Health, 370 -378. https://doi.org/10.1080/20477724.2020.1803628

Genetic control strategies aimed to bias the sex of progenies towards males present a promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio distortion (SD) system was successfully engineered in Anopheles gambiae b... Read More about Cellular mechanisms regulating synthetic sex ratio distortion in the Anopheles gambiae germline.

Author Correction: A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. (2020)
Journal Article
Simoni, A., Hammond, A. M., Beaghton, A. K., Galizi, R., Taxiarchi, C., Kyrou, K., …Crisanti, A. (2020). Author Correction: A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Nature Biotechnology, https://doi.org/10.1038/s41587-020-0658-1

An amendment to this paper has been published and can be accessed via a link at the top of the paper.