Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation
(2021)
Journal Article
Fuchs, S., T. Garrood, W., Beber, A., Hammond, A., Galizi, R., Gribble, M., …Nolan, T. (2021). Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation. PLOS genetics, Article e1009740. https://doi.org/10.1371/journal.pgen.1009740
CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations in the laboratory. This class of gene drives relies on CRISPR-Cas9 cleavage of a target se... Read More about Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.