All Outputs (3)

Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest (2015)
Journal Article
McCarthy, H. S., Richardson, J. B., Parker, J. C., & Roberts, S. (2015). Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest. Cartilage, 7(1), 7-15. https://doi.org/10.1177/1947603515607963

Objective To establish if harvesting cartilage to source chondrocytes for autologous chondrocyte implantation (ACI) results in donor site morbidity. Design Twenty-three patients underwent ACI for chondral defects of either the ankle or the hip.... Read More about Evaluating Joint Morbidity after Chondral Harvest for Autologous Chondrocyte Implantation (ACI): A Study of ACI-Treated Ankles and Hips with a Knee Chondral Harvest.

ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion (2015)
Journal Article
Roberts, S., Evans, H., Wright, K., van Niekerk, L., Caterson, B., Richardson, J., …Kuiper, J. (2015). ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion. Osteoarthritis and Cartilage, 23(9), 1622-1626. https://doi.org/10.1016/j.joca.2015.05.006

Objective To evaluate the potential of ADAMTS-4 (aggrecanase -1) activity in synovial fluid (SF) as a biomarker of knee injury and joint disease. Design We have measured ADAMTS-4 activity in the synovial fluid of 170 orthopaedic patients with di... Read More about ADAMTS-4 activity in synovial fluid as a biomarker of inflammation and effusion.

Wnt-signalling in human articular chondrocytes (2015)
Journal Article
McCarthy, H., Owen, S., & Roberts, S. (2015). Wnt-signalling in human articular chondrocytes. International Journal of Experimental Pathology, 96(2), A27

Introduction Aberrant Wnt-signalling in cartilage results inchondrocyte dedifferentiation, hypertrophy, loss of type II collagen, aggrecan and glycosaminoglycans. Articular chondrocytes experience a pO2 gradient from~6% (surface) to~1% (within deeper... Read More about Wnt-signalling in human articular chondrocytes.