All Outputs (11)

Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors (2022)
Journal Article
Xie, M., Leng, T., Maysami, S., Pearson, A., Simon, R., Xiong, Z., & Meller, R. (2022). Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors. Biomolecules, https://doi.org/10.3390/biom12091214

In this study, we characterize biophysical changes in NMDA receptor function in response to brief non-injurious ischemic stress (ischemic preconditioning). Electrophysiological studies show NMDA receptor function is reduced following preconditioning... Read More about Changes in NMDA Receptor Function in Rapid Ischemic Tolerance: A Potential Role for Tri-Heteromeric NMDA Receptors.

Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis (2016)
Journal Article
Orset, C., Haelewyn, B., Allan, S. M., Ansar, S., Campos, F., Cho, T. H., …Vivien, D. (2016). Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke, 47(5), 1312-1318. https://doi.org/10.1161/strokeaha.116.012238

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke (2015)
Journal Article
Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., …Maysami, S. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. https://doi.org/10.1177/0271678X15606714

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in... Read More about A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. (2015)
Journal Article
Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., McColl, B., & Lawrence, C. (2015). Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. Journal of Neuroinflammation, 140 - ?. https://doi.org/10.1186/s12974-015-0359-8

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesit... Read More about Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke..

The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury (2013)
Journal Article
Rodriguez-Grande, B., Swana, M., Nguyen, L., Englezou, P., Maysami, S., Allan, S. M., …Pinteaux, E. (2014). The Acute-Phase Protein PTX3 is an Essential Mediator of Glial Scar Formation and Resolution of Brain Edema after Ischemic Injury. Journal of Cerebral Blood Flow and Metabolism, 34(3), 480-488. https://doi.org/10.1038/jcbfm.2013.224

Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. (2012)
Journal Article
Maysami, S., Bowie, A., Denes, A., Nilsson, O., Leow-Dyke, S., Allen, C., …Pinteaux, E. (2012). Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro. Journal of Neuroinflammation, 230 - ?. https://doi.org/10.1186/1742-2094-9-230

BACKGROUND: The innate immune response in the brain is initiated by pathogen-associated molecular patterns (PAMPS) or danger-associated molecular patterns (DAMPS) produced in response to central nervous system (CNS) infection or injury. These molecul... Read More about Neuronal Toll-like receptor 4 signaling induces brain endothelial activation and neutrophil transmigration in vitro..

Inhibition of Acid Sensing Ion Channel Currents by Lidocaine in Cultured Mouse Cortical Neurons (2011)
Journal Article
Lin, J., Chu, X., Maysami, S., Li, M., Si, H., Cottrell, J. E., …Xiong, Z. (2011). Inhibition of Acid Sensing Ion Channel Currents by Lidocaine in Cultured Mouse Cortical Neurons. Anesthesia and Analgesia, 112(4), 977-981. https://doi.org/10.1213/ANE.0b013e31820a511c

Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism (2008)
Journal Article
Pignataro, G., Maysami, S., Studer, F. E., Wilz, A., Simon, R. P., & Boison, D. (2008). Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. Journal of Cerebral Blood Flow and Metabolism, 28(1), 17-23. https://doi.org/10.1038/sj.jcbfm.9600499

Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: Implications for myelination (2006)
Journal Article
Maysami, S., Nguyen, D., Zobel, F., Heine, S., Hoepfner, M., & Stangel, M. (2006). Oligodendrocyte precursor cells express a functional chemokine receptor CCR3: Implications for myelination. Journal of Neuroimmunology, 178(1-2), 17-23. https://doi.org/10.1016/j.jneuroim.2006.05.021

Effects of interferon-beta on oligodendroglial cells (2006)
Journal Article
Heine, S., Ebnet, J., Maysami, S., & Stangel, M. (2006). Effects of interferon-beta on oligodendroglial cells. Journal of Neuroimmunology, 177(1-2), 173-180. https://doi.org/10.1016/j.jneuroim.2006.04.016

Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12 (2006)
Journal Article
Maysami, S., Nguyen, D., Zobel, F., Pitz, C., Heine, S., Hoepfner, M., & Stangel, M. (2006). Modulation of rat oligodendrocyte precursor cells by the chemokine CXCL12. NeuroReport, 17(11), 1187-1190