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All Outputs (165)

Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey (2025)
Journal Article
O'Brien, A. V., Muller, S., Liddle, J., Thomas, M. J., & Mallen, C. D. (2025). Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey. Musculoskeletal Care, 23(3), Article e70155. https://doi.org/10.1002/msc.70155

Introduction: Polymyalgia rheumatica (PMR) international management guidelines advocate patient education and individualised exercises but lack evidence and physiotherapy practice for PMR is unknown. PMR is typically treated with glucocorticoids, but... Read More about Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey.

Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England (2025)
Journal Article
Lawton, S. A., Mallen, C., Chew-Graham, C., Kingstone, T., Muller, S., Lewis, S., Bajpai, R., & Helliwell, T. (2025). Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England. BMJ Open, 15(6), 1-7. https://doi.org/10.1136/bmjopen-2024-095040

To examine the number of patients screening positive for depression, while self-completing an automated check-in screen prior to a general practice consultation. A descriptive cross-sectional study. 10 general practices in the West Midlands, England.... Read More about Case-finding for depression in primary care (CAIRO): a multicentre, cross-sectional study in England.

Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study (2025)
Journal Article
Hamad, N., Muller, S., Hider, S., Partington, R., Helliwell, T., Butt, H., Hay, C., & Mallen, C. (2025). Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study. Rheumatology Advances in Practice, 1-19. https://doi.org/10.1093/rap/rkaf060

Objectives
To investigate the anatomical locations of pain and stiffness in people with polymyalgia rheumatica (PMR) and how it compares to the general population.

Methods
739 people with PMR were invited to complete a postal survey at the time... Read More about Patterns of pain and stiffness over 5 years in polymyalgia rheumatica: results from the PMR Cohort Study.

Healthcare use and its variation in people with fibromyalgia: a systematic review protocol (2025)
Journal Article
Byrne, A., Twohig, H., Muller, S., & Scott, I. (2025). Healthcare use and its variation in people with fibromyalgia: a systematic review protocol. Primary Health Care Research & Development, 26, 1-5. https://doi.org/10.1017/S1463423625000362

Aim:
A crucial step towards improving the care of people with fibromyalgia is understanding current practice. Our systematic review aims to address this by synthesising the global evidence around healthcare use in people with fibromyalgia, including... Read More about Healthcare use and its variation in people with fibromyalgia: a systematic review protocol.

P055 Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S., Mallen, C. D., Jordan, K. P., & Muller, S. (2025, April). P055 Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated w... Read More about P055 Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum.

P194 Prescribing of bisphosphonates and their impact on the risk of fractures in patients with polymyalgia rheumatica (PMR) in England: a cohort study and target-trial in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Twohig, H., Jenkinson, D., Bailey, J., Hider, S., Scott, I., & Muller, S. (2025, April). P194 Prescribing of bisphosphonates and their impact on the risk of fractures in patients with polymyalgia rheumatica (PMR) in England: a cohort study and target-trial in the Clinical Practice Research Datalink Aurum. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims PMR is a common indication for long-term glucocorticoid (GC) treatment with real-world data on GC treatment in PMR showing that one quarter of patients continue them for >4 years. People with PMR have a 63% increased risk of fractu... Read More about P194 Prescribing of bisphosphonates and their impact on the risk of fractures in patients with polymyalgia rheumatica (PMR) in England: a cohort study and target-trial in the Clinical Practice Research Datalink Aurum.

P102 Pain management and its variation by deprivation in patients with inflammatory arthritis: the PAIN PATH survey (2025)
Presentation / Conference Contribution
Scott, I. C., Daud, N., Hider, S., Paskins, Z., Twohig, H., Halliday, N., Mallen, C. D., Jordan, K. P., & Muller, S. (2025, April). P102 Pain management and its variation by deprivation in patients with inflammatory arthritis: the PAIN PATH survey. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims UK-based electronic health record studies show that many patients with inflammatory arthritis (IA) receive opioid and gabapentinoid prescriptions - particularly in areas of deprivation - despite little and no evidence for efficacy, re... Read More about P102 Pain management and its variation by deprivation in patients with inflammatory arthritis: the PAIN PATH survey.

P069 The acceptability of ePROMs in the routine care of patients with inflammatory arthritis and its variation across patient groups: a mixed-methods study (2025)
Presentation / Conference Contribution
Cox, N., Kettle, C., Wang, H., Dutta, S., Packham, J., Galloway, J., Hill, J., Muller, S., Hider, S., Paskins, Z., Bullock, L., & Scott, I. (2025, April). P069 The acceptability of ePROMs in the routine care of patients with inflammatory arthritis and its variation across patient groups: a mixed-methods study. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims Electronic patient-reported outcome measures (ePROMs) can facilitate innovative, holistic care for people with inflammatory arthritis (IA). The crucial first step in their implementation is understanding their feasibility and acceptab... Read More about P069 The acceptability of ePROMs in the routine care of patients with inflammatory arthritis and its variation across patient groups: a mixed-methods study.

P057 The relationship between pain and mental health in people with inflammatory arthritis: a systematic review (2025)
Presentation / Conference Contribution
Cox, N., Hawarden, A., Kettle, C., Bajpai, R., Farooq, S., Twohig, H., Muller, S., & Scott, I. (2025, April). P057 The relationship between pain and mental health in people with inflammatory arthritis: a systematic review. Poster presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England, UK

Background/Aims Pain is common in inflammatory arthritis (IA) and understanding how to best treat it is important. Depression/anxiety are prevalent IA-comorbidities. The evidence they associate with pain is uncertain. This PROSPERO-registered (CRD420... Read More about P057 The relationship between pain and mental health in people with inflammatory arthritis: a systematic review.

OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink (2025)
Presentation / Conference Contribution
Partington, R., Muller, S., Mallen, C. D., Mamas, M. A., Forrester, H., & Roddy, E. (2025, April). OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink. Presented at British Society for Rheumatology Annual Conference, Manchester Central Convention Complex, Manchester, England

Background/Aims Febuxostat is recommended as first line urate-lowering therapy (ULT) for gout in the UK. However, concerns were raised regarding its cardiovascular (CV) safety. Current guidance advises caution when using it in people with CV disease,... Read More about OA01 Long-term cardiovascular safety of febuxostat compared with allopurinol or no urate-lowering treatment in people with gout: a cohort study in UK primary care using the Clinical Practice Research Datalink.

OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum (2025)
Presentation / Conference Contribution
Adeniran, K., Partington, R., Bailey, J., Mallen, C. D., Muller, S., & Scott, I. C. (2025, April). OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum. Presented at British Society for Rheumatology Annual Conference 2025, Manchester Central Convention Complex, Manchester, England

Background/Aims Fibromyalgia, a common condition characterised by chronic widespread pain/somatic symptoms, has substantial impacts on patients’ lives and healthcare use. Previous studies suggest it is far more common in inflammatory arthritis than t... Read More about OA19 The prevalence of fibromyalgia in people with inflammatory arthritis: an observational study in the Clinical Practice Research Datalink Aurum.

Anxiety, Fear, and Kinesiophobia: Challenges Faced by UK Physiotherapists in Managing Polymyalgia Rheumatica - Findings from a Qualitative Study (2025)
Presentation / Conference Contribution
O’Brien, A., Muller, S., Liddle, J., Thomas, M., & Mallen, C. (2025, March). Anxiety, Fear, and Kinesiophobia: Challenges Faced by UK Physiotherapists in Managing Polymyalgia Rheumatica - Findings from a Qualitative Study. Presented at Midlands Rheumatology Society Spring Meeting, British Motor Museum, Banbury Road, Gaydon, Warwickshire

Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review] (2024)
Journal Article
Imantalab, D., Singh Sokhal, B., Prasanna Kumar Menon, S., Kalra, S., Muller, S., & Mallen, C. (2024). Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review]. NIHR Open Research, 1-14. https://doi.org/10.3310/nihropenres.13786.1

Motor Neurone Disease (MND) is a neurodegenerative condition affecting motor neurons in spinal cord and brainstem, leading to a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United States over a 2... Read More about Demographic trends of motor neurone disease-associated mortality from 1999-2020 in the United States [version 1; peer review: awaiting peer review].

Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum (2024)
Journal Article
Scott, I. C., Daud, N., Bailey, J., Twohig, H., Hider, S. L., Mallen, C. D., Jordan, K. P., & Muller, S. (2024). Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum. BMC Medicine, 22(1), 575. https://doi.org/10.1186/s12916-024-03774-5

Background: Gabapentinoids are increasingly prescribed in inflammatory arthritis (IA), despite no trial evidence for efficacy at managing pain in this population. Observational studies in non-IA populations suggest gabapentinoids are associated with... Read More about Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case–control study in the Clinical Practice Research Datalink Aurum.

Association of air pollution from a landfill site with primary care consultation (2024)
Preprint / Working Paper
Jordan, K. P., Muller, S., Usman, M., Bailey, J., Burton, C., Lawton, S. A., Mallen, C. D., Mason, K. J., Wathall, S., & van der Windt, D. A. Association of air pollution from a landfill site with primary care consultation

Background Waste landfill sites are associated with gaseous emissions and this air pollution can cause unpleasant smells (“malodour”). This causes concerns about its impact on the health of the local population. This study assessed change in general... Read More about Association of air pollution from a landfill site with primary care consultation.

Temporal Trends in Parkinson's Disease Related Mortality from 1999-2020: A National Analysis. (2024)
Journal Article
Singh Sokhal, B., Prasanna Kumar Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). Temporal Trends in Parkinson's Disease Related Mortality from 1999-2020: A National Analysis. NIHR Open Research, https://doi.org/10.3310/nihropenres.13623.1

IntroductionParkinson's disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence is rising, and studies have reported potential sex and race disparities in patient outcomes. Dat... Read More about Temporal Trends in Parkinson's Disease Related Mortality from 1999-2020: A National Analysis..

2235 National Trends in motor neurone disease-associated mortality from 1999–2020 (2024)
Presentation / Conference Contribution
Imantalab, D., Sokhal, B., Menon, S., Kara, S., Muller, S., & Mallen, C. 2235 National Trends in motor neurone disease-associated mortality from 1999–2020. Presented at British Geriatrics Society Spring 2024 Meeting (22 -24 May 2024), Vox, Birmingham, UK & Online

Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting the spinal cord and brainstem, commonly associated with a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United S... Read More about 2235 National Trends in motor neurone disease-associated mortality from 1999–2020.

2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study (2024)
Presentation / Conference Contribution
Sokhal, B., Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study. Presented at British Geriatrics Society Spring 2024 Meeting (22-24 May 2024), The Vox, Birminham, UK

Introduction Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence of PD is increasing and the literature demonstrates potential sex and race disparities in patie... Read More about 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study.