All Outputs (3)

Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications (2020)
Journal Article
Finch, L., Harris, S., Solomou, G., Sen, J., Tzerakis, N., Emes, R. D., …Chari, D. M. (2020). Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications. Journal of Controlled Release, 321, 553-563. https://doi.org/10.1016/j.jconrel.2020.02.028

High transplant cell loss is a major barrier to translation of stem cell therapy for pathologies of the brain and spinal cord. Encapsulated delivery of stem cells in biomaterials for cell therapy is gaining popularity but experimental research has ov... Read More about Safe nanoengineering and incorporation of transplant populations in a neurosurgical grade biomaterial, DuraGen PlusTM, for protected cell therapy applications.

Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides (2015)
Journal Article
Hart, S. R., Kenny, L. C., Myers, J. E., & Baker, P. N. (2015). Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides. International Journal of Mass Spectrometry, 391, 41-46. https://doi.org/10.1016/j.ijms.2015.08.025

Urine as a biofluid is commonly used in clinical diagnostics, including those performed during pregnancy. Urine is a rich source of polypeptides and polypeptidic protein degradation products, which have been filtered from blood plasma, thus urine has... Read More about Electron transfer dissociation of native peptides facilitates enhanced identification of urinary peptides.

Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease.
Journal Article
Mitchell​, W. D., Orme, R. P., Hart, S. R., & Fricker, R. A. (2018). Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease. PeerJ PrePrints, https://doi.org/10.7287/peerj.preprints.26443v2

Parkinson’s disease is a widespread condition caused by degeneration of dopamine neurons in the midbrain. A number of proteins are known to be important to signalling mechanisms present in the midbrain during natural dopamine neuron development, an... Read More about Using bioinformatics for the identification of key peptides to engineer dopamine neurons. Towards a therapy for Parkinson’s disease..