All Outputs (7)

Inhibition of influenza H5N1 invasion by modified heparin derivatives (2015)
Journal Article
Skidmore, M. A., Kajaste-Rudnitski, A., Wells, N. M., Guimond, S. E., Rudd, T. R., Yates, E. A., & Vicenzi, E. Inhibition of influenza H5N1 invasion by modified heparin derivatives. MedChemComm, 6(4), 640-646. https://doi.org/10.1039/c4md00516c

Influenza remains a serious health threat, with resistance to frontline drugs becoming more common, and new treatments urgently sought. One strategy for the inhibition of the attachment of influenza to host cells is to employ chemically modified hepa... Read More about Inhibition of influenza H5N1 invasion by modified heparin derivatives.

Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding (2015)
Journal Article
Solari, V., Rudd, T. R., Guimond, S. E., Powell, A. K., Turnbull, J. E., & Yates, E. A. Heparan sulfate phage display antibodies recognise epitopes defined by a combination of sugar sequence and cation binding. Organic and Biomolecular Chemistry, 13(21), 6066-6072. https://doi.org/10.1039/c5ob00564g

Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions (2015)
Journal Article
Kalus, I., Rohn, S., Puvirajesinghe, T. M., Guimond, S. E., Eyckerman-Kölln, P. J., ten Dam, G., …Dierks, T. Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions. PloS one, 10(10), e0139853. https://doi.org/10.1371/journal.pone.0139853

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis (2015)
Journal Article
Duckworth, C. A., Guimond, S. E., Sindrewicz, P., Hughes, A. J., French, N. S., Lian, L., …Yu, L. (2015). Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis. Oncotarget, 6(27), 23671-23687. https://doi.org/10.18632/oncotarget.4409

2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline (2015)
Journal Article
Chan, W. K., Howe, K., Clegg, J. M., Guimond, S. E., Price, D. J., Turnbull, J. E., & Pratt, T. 2-O Heparan Sulfate Sulfation by Hs2st Is Required for Erk/Mapk Signalling Activation at the Mid-Gestational Mouse Telencephalic Midline. PloS one, 10(6), e0130147. https://doi.org/10.1371/journal.pone.0130147

Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation (2015)
Journal Article
Theodoraki, A., Hu, Y., Poopalasundaram, S., Oosterhof, A., Guimond, S. E., Disterer, P., …Bouloux, P. (2015). Distinct patterns of heparan sulphate in pancreatic islets suggest novel roles in paracrine islet regulation. Molecular and Cellular Endocrinology, 399, 296-310. https://doi.org/10.1016/j.mce.2014.09.011

Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications (2015)
Journal Article
Tyler, P. C., Guimond, S. E., Turnbull, J. E., & Zubkova, O. V. (2015). Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications. Angewandte Chemie International Edition, 54(9), 2718-2723. https://doi.org/10.1002/anie.201410251