All Outputs (4)

Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles (2024)
Journal Article
Ramsden, J. I., Zucoloto da Costa, B., Heath, R. S., Marshall, J. R., Derrington, S. R., Mangas-Sanchez, J., Montgomery, S. L., Mulholland, K. R., Cosgrove, S. C., & Turner, N. J. (2024). Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles. ACS catalysis, 14(19), 14703-14710. https://doi.org/10.1021/acscatal.4c03832

Saturated N-heterocycles constitute a vital scaffold for pharmaceutical chemistry but are challenging to access synthetically, particularly asymmetrically. Here, we demonstrate how imine reductases can achieve annulation through tandem inter- and int... Read More about Bifunctional Imine Reductase Cascades for the Synthesis of Saturated N-Heterocycles.

Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water (2024)
Journal Article
Wahart, A. J. C., Beardmore, L. N. D., Field, R. A., Cosgrove, S. C., & Miller, G. J. (in press). Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water. Organic Letters, 26(31), 6642-6646. https://doi.org/10.1021/acs.orglett.4c02201

We explore biocatalytic aldehyde generation under aqueous conditions, concomitantly delivering access to a one-pot Wittig reaction using stabilized phosphoranes and granting diverse alkene products. Using a recombinant choline oxidase mutant, we firs... Read More about Tandem One-Pot Biocatalytic Oxidation and Wittig Reaction in Water.

Future directions in flow biocatalysis: The impact of new technology on sustainability (2024)
Journal Article
Ruscoe, R. E., & Cosgrove, S. C. (2024). Future directions in flow biocatalysis: The impact of new technology on sustainability. Current Opinion in Green and Sustainable Chemistry, 49, Article 100954. https://doi.org/10.1016/j.cogsc.2024.100954

Flow chemistry is now a key technology for synthetic chemistry, with the different operating windows available allowing new chemistry to be optimised and discovered. The related area of flow biocatalysis is also becoming increasingly recognised as an... Read More about Future directions in flow biocatalysis: The impact of new technology on sustainability.

Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. (2024)
Journal Article
Holder, L., Yuce, E., Oriomah, G., Jenkins, A.-P., Reynisson, J., Winter, A., & Cosgrove, S. (in press). Accessing active fragments for drug discovery utilising nitroreductase biocatalysis. ChemBioChem, 25(18), Article e202400428. https://doi.org/10.1002/cbic.202400428

Biocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space. Here, we have shown a promiscuous nitroreduct... Read More about Accessing active fragments for drug discovery utilising nitroreductase biocatalysis..