All Outputs (4)

An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31 (2006)
Journal Article
Chakravorty, S. J., McGettrick, H. M., Butler, L. M., Buckley, C. D., Rainger, G. . E., & Nash, G. B. (2006). An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31. Biorheology, 43(1), 71-82

To model the later stages of neutrophil migration into tissue, we developed an assay in which human umbilical vein endothelial cells (HUVEC) were cultured on porous filters, treated with the inflammatory cytokine tumour necrosis factor-α (TNF), and t... Read More about An in vitro model for analysing neutrophil migration into and away from the sub-endothelial space: Roles of flow and CD31.

The effect of Plasmodium falciparum infection on expression of monocyte surface molecules (2006)
Journal Article
Jenkins, N., Chakravorty, S., Urban, B., Kai, O., Marsh, K., & Craig, A. (2006). The effect of Plasmodium falciparum infection on expression of monocyte surface molecules. Transactions of The Royal Society of Tropical Medicine and Hygiene, 100(11), 1007-1012. https://doi.org/10.1016/j.trstmh.2006.01.005

Plasmodium falciparum infection may result in severe malaria in susceptible individuals. The pathogenesis of severe disease is probably a combination of the sequestration of infected erythrocytes and overstimulation of the immune response. Monocytes... Read More about The effect of Plasmodium falciparum infection on expression of monocyte surface molecules.

von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation (2006)
Journal Article
Hollestelle, M. J., Donkor, C., Mantey, E. A., Chakravorty, S. J., Craig, A., Akoto, A. O., …Bunn, J. (2006). von Willebrand factor propeptide in malaria: evidence of acute endothelial cell activation. British Journal of Haematology, 133(5), 562-569. https://doi.org/10.1111/j.1365-2141.2006.06067.x

Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1 (2006)
Journal Article
Dormeyer, M., Adams, Y., Kramer, B., Chakravorty, S., Tse, M. T., Pegoraro, S., …Craig, A. (2006). Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1. Antimicrobial Agents and Chemotherapy, 50(2), 724-730. https://doi.org/10.1128/aac.50.2.724-730.2006

Adhesion of Plasmodium falciparum-infected erythrocytes (IE) to host endothelium has been associated with pathology in malaria. Although the interaction with endothelial cells can be complex due to the relatively large number of host receptors availa... Read More about Rational Design of Anticytoadherence Inhibitors forPlasmodium falciparumBased on the Crystal Structure of Human Intercellular Adhesion Molecule 1.