All Outputs (7)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes (2023)
Journal Article
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A. A., Peters, J. A., Veale, E. L., …Wong, S. S. (2023). The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. British Journal of Pharmacology, 180, S289-S373. https://doi.org/10.1111/bph.16181

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interacti... Read More about The Concise Guide to PHARMACOLOGY 2023/24: Enzymes.

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites (2023)
Journal Article
Li, C., Barroeta, A. B., Wong, S. S., Kim, H. J., Pathak, M., Dreveny, I., …Emsley, J. (2023). Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites. Journal of Thrombosis and Haemostasis, 21(9), 2378-2389. https://doi.org/10.1016/j.jtha.2023.03.042

Background High–molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-termi... Read More about Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites.

Do these three popular anti-ageing skincare ingredients work? Here’s what the evidence says (2022)
Digital Artefact
Wong, S. S., & Grazier, N. (2022). Do these three popular anti-ageing skincare ingredients work? Here’s what the evidence says. [Blog Style Article]

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes (2021)
Journal Article
Alexander, S. P. H., Fabbro, D., Kelly, E., Mathie, A., Peters, J. A., Veale, E. L., …Wong, S. S. (2021). THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. British Journal of Pharmacology, 178(S1), S313 - S411. https://doi.org/10.1111/bph.15542

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on select... Read More about THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes.

Molecular profiling of Peru Balsam reveals active ingredients responsible for its pharmaceutical properties (2020)
Journal Article
Wong. (2020). Molecular profiling of Peru Balsam reveals active ingredients responsible for its pharmaceutical properties. Natural Product Research, https://doi.org/10.1080/14786419.2020.1753056

AbstractPeru Balsam, a resinous substance derived from Myroxylon balsamum var. pereirae, has historically been used as a topical ointment for various skin conditions such as scabies, poorly healing wounds, eczema, and haemorrhoids. The ingredients re... Read More about Molecular profiling of Peru Balsam reveals active ingredients responsible for its pharmaceutical properties.

A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain (2016)
Journal Article
Wong, S. S., Østergaard, S., Hall, G., Li, C., Williams, P. M., Stennicke, H., & Emsley, J. (2016). A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain. Blood, 127(23), 2915-2923. https://doi.org/10.1182/blood-2015-10-676122

Factor XI (FXI) is the zymogen of FXIa, which cleaves FIX in the intrinsic pathway of coagulation. FXI is known to exist as a dimer and interacts with multiple proteins via its 4 apple domains in the “saucer section” of the enzyme; however, to date,... Read More about A novel DFP tripeptide motif interacts with the coagulation factor XI apple 2 domain.

The Concise Guide to PHARMACOLOGY 2015/16: Overview: The Concise Guide to PHARMACOLOGY 2015/16: Overview (2015)
Journal Article
Alexander, S. P., Kelly, E., Marrion, N., Peters, J. A., Benson, H. E., Faccenda, E., …Wong, S. S. (2015). The Concise Guide to PHARMACOLOGY 2015/16: Overview: The Concise Guide to PHARMACOLOGY 2015/16: Overview. British Journal of Pharmacology, 172(24), 5729-5743. https://doi.org/10.1111/bph.13347

The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.... Read More about The Concise Guide to PHARMACOLOGY 2015/16: Overview: The Concise Guide to PHARMACOLOGY 2015/16: Overview.