Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites

Li, Chan; Barroeta, Awital Bar; Wong, Szu Shen; Kim, Hyo Jung; Pathak, Monika; Dreveny, Ingrid; Meijers, Joost C.M.; Emsley, Jonas

doi:10.1016/j.jtha.2023.03.042

Research Repository

All Outputs (2)

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes (2023)
Journal Article

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interacti... Read More about The Concise Guide to PHARMACOLOGY 2023/24: Enzymes.

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites (2023)
Journal Article

Background High–molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-termi... Read More about Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites.