All Outputs (16)

Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells (2023)
Journal Article
Llewellyn, J., Mallikarjun, V., Gilbert, H., Richardson, S., Hubbard, S., Swift, J., …Osipova, M. (2023). Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells. Proceedings of the National Academy of Sciences of the United States of America, https://doi.org/10.1073/pnas.2210745120

Cells respond to stress by synthesizing chaperone proteins that seek to correct protein misfolding and maintain function. However, abrogation of protein homeostasis is a hallmark of aging, leading to loss of function and the formation of proteotoxic... Read More about Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells.

Acidic PH inhibits the stiffness response in human bone marrow mesenchymal stem cells (BM-MSCS) (2023)
Journal Article
Usta, Y., Lawless, C., Swift, J., Richardson, S., & Gilbert, H. (2023). Acidic PH inhibits the stiffness response in human bone marrow mesenchymal stem cells (BM-MSCS). International Journal of Clinical and Experimental Pathology, A19 - A19. https://doi.org/10.1111/iep.12471

Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence (2022)
Journal Article
Mallikarjun, V., Dobre, O., Jackson, M., Kidd, M., Llewellyn, J., Gilbert, H., …Swift, J. (2022). Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence. arXiv,

ABSTRACT Tissues are maintained by homeostatic feedback mechanisms where cells respond to, but also modify, the chemical and mechanical properties of the surrounding extracellular matrix. Mesenchymal stem cells (MSCs) resident in the marrow niche exp... Read More about Loss of cytoskeletal proteostasis links dysregulation of cell size and mechanotransduction in mesenchymal stem cell senescence.

Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation (2020)
Journal Article
Hodgkinson, T., Gilbert, H., Diwan, A., Hoyland, J., Richardson, S., & Pandya, T. (2020). Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation. International Journal of Molecular Sciences, 7143 - 7143. https://doi.org/10.3390/ijms21197143

Growth differentiation factor (GDF) family members have been implicated in the development and maintenance of healthy nucleus pulposus (NP) tissue, making them promising therapeutic candidates for treatment of intervertebral disc (IVD) degeneration a... Read More about Regenerative Response of Degenerate Human Nucleus Pulposus Cells to GDF6 Stimulation.

Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion (2019)
Journal Article
Blythe, N. M., Muraki, K., Ludlow, M. J., Stylianidis, V., Gilbert, H. T., Evans, E. L., …Turner, N. A. (2019). Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion. Journal of Biological Chemistry, 294(46), 17395-17408. https://doi.org/10.1074/jbc.ra119.009167

Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading (2019)
Journal Article
Gilbert, H. T. J., Mallikarjun, V., Dobre, O., Jackson, M. R., Pedley, R., Gilmore, A. P., …Swift, J. Nuclear decoupling is part of a rapid protein-level cellular response to high-intensity mechanical loading. Nature communications, 10(1), https://doi.org/10.1038/s41467-019-11923-1

The consequences of ageing, progeroid syndromes and cellular senescence on mechanotransduction and the nucleus (2019)
Journal Article
Gilbert, H. T., & Swift, J. (2019). The consequences of ageing, progeroid syndromes and cellular senescence on mechanotransduction and the nucleus. Experimental Cell Research, 378(1), 98-103. https://doi.org/10.1016/j.yexcr.2019.03.002

An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness (2018)
Journal Article
Galarza Torre, A., Shaw, J. E., Wood, A., Gilbert, H. T. J., Dobre, O., Genever, P., …Swift, J. An immortalised mesenchymal stem cell line maintains mechano-responsive behaviour and can be used as a reporter of substrate stiffness. Scientific reports, 8(1), https://doi.org/10.1038/s41598-018-27346-9

Degenerate intervertebral disc‐like pH induces a catabolic mechanoresponse in human nucleus pulposus cells (2018)
Journal Article
Hodson, N. W., Patel, S., Richardson, S. M., Hoyland, J. A., & Gilbert, H. T. J. (2018). Degenerate intervertebral disc‐like pH induces a catabolic mechanoresponse in human nucleus pulposus cells. JOR Spine, 1(1), https://doi.org/10.1002/jsp2.1004

Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target (2016)
Journal Article
Gilbert, H. T. J., Hodson, N., Baird, P., Richardson, S. M., & Hoyland, J. A. (in press). Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel -3 as a potential therapeutic target. Scientific reports, 6(1), https://doi.org/10.1038/srep37360

Interior decoration: Adapting multiwell plates for high throughput mechanobiology (2015)
Journal Article
Gilbert, H. T. J., & Swift, J. (2015). Interior decoration: Adapting multiwell plates for high throughput mechanobiology. Biotechnology Journal, 10(10), 1513-1514. https://doi.org/10.1002/biot.201500308

In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering (2014)
Journal Article
Truong, V. X., Ablett, M. P., Gilbert, H. T. J., Bowen, J., Richardson, S. M., Hoyland, J. A., & Dove, A. P. In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering. Biomaterials science / Royal Society of Chemistry, 2(2), 167-175. https://doi.org/10.1039/c3bm60159e

A microstereolithography resin based on thiol-ene chemistry: towards biocompatible 3D extracellular constructs for tissue engineering (2013)
Journal Article
Barker, I. A., Ablett, M. P., Gilbert, H. T. J., Leigh, S. J., Covington, J. A., Hoyland, J. A., …Dove, A. P. (in press). A microstereolithography resin based on thiol-ene chemistry: towards biocompatible 3D extracellular constructs for tissue engineering. Biomaterials science / Royal Society of Chemistry, 2(4), 472-475. https://doi.org/10.1039/c3bm60290g

Stem Cell Regeneration of Degenerated Intervertebral Discs: Current Status (Update) (2013)
Journal Article
Gilbert, H. T. J., Hoyland, J. A., & Richardson, S. M. (2013). Stem Cell Regeneration of Degenerated Intervertebral Discs: Current Status (Update). Current Pain and Headache Reports, 17(12), Article ARTN 377. https://doi.org/10.1007/s11916-013-0377-0

Integrin – Dependent Mechanotransduction in Mechanically Stimulated Human Annulus Fibrosus Cells: Evidence for an Alternative Mechanotransduction Pathway Operating with Degeneration (2013)
Journal Article
Gilbert, H. T. J., Nagra, N. S., Freemont, A. J., Millward-Sadler, S. J., & Hoyland, J. A. Integrin – Dependent Mechanotransduction in Mechanically Stimulated Human Annulus Fibrosus Cells: Evidence for an Alternative Mechanotransduction Pathway Operating with Degeneration. PloS one, 8(9), e72994. https://doi.org/10.1371/journal.pone.0072994

Fabrication of 3-Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System (2012)
Journal Article
Leigh, S. J., Gilbert, H. T. J., Barker, I. A., Becker, J. M., Richardson, S. M., Hoyland, J. A., …Dove, A. P. (2013). Fabrication of 3-Dimensional Cellular Constructs via Microstereolithography Using a Simple, Three-Component, Poly(Ethylene Glycol) Acrylate-Based System. Biomacromolecules, 14(1), 186-192. https://doi.org/10.1021/bm3015736