ApoE isoform-specific regulation of regeneration in the peripheral nervous system

Comley, Laura H.; Fuller, Heidi R.; Wishart, Thomas M.; Mutsaers, Chantal A.; Thomson, Derek; Wright, Ann K.; Ribchester, Richard R.; Morris, Glenn E.; Parson, Simon H.; Horsburgh, Karen; Gillingwater, Thomas H.

doi:10.1093/hmg/ddr147

All Outputs (5)

Transcriptional effects of corticosteroid therapy on myelin genesis and neuronal health (2011)
Journal Article
Chari, D. (2011). Transcriptional effects of corticosteroid therapy on myelin genesis and neuronal health. Midlands Medicine, 26(3),

Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies (2011)
Journal Article
Yiu, H. H. P., Pickard, M. R., Olariu, C. I., Williams, S. R., Chari, D. M., & Rosseinsky, M. J. (2012). Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies. Pharmaceutical Research, 29(5), 1328-1343. https://doi.org/10.1007/s11095-011-0632-1

Purpose To develop Fe3O4-PEI-RITC magnetic nanoparticles with multimodal MRI-fluorescence imaging and transfection capability, for use in neural cell replacement therapies. Methods The Fe3O4-PEI-RITC MNPs were synthesised through a multi-step ch... Read More about Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies.

Current research on SMN protein and treatment strategies for spinal muscular atrophy (2011)
Journal Article
Humphrey, E., Fuller, H. R., & Morris, G. E. (2012). Current research on SMN protein and treatment strategies for spinal muscular atrophy. Neuromuscular Disorders, 22(2), 193-197. https://doi.org/10.1016/j.nmd.2011.06.002

Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies (2011)
Journal Article
Jenkins, S. I., Pickard, M. R., Granger, N., & Chari, D. M. (2011). Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies. ACS Nano, 5(8), 6527-6538. https://doi.org/10.1021/nn2018717

This study has tested the feasibility of using physical delivery methods, employing static and oscillating field “magnetofection” techniques, to enhance magnetic nanoparticle-mediated gene transfer to rat oligodendrocyte precursor cells derived for t... Read More about Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies.

ApoE isoform-specific regulation of regeneration in the peripheral nervous system (2011)
Journal Article
Comley, L. H., Fuller, H. R., Wishart, T. M., Mutsaers, C. A., Thomson, D., Wright, A. K., …Gillingwater, T. H. (2011). ApoE isoform-specific regulation of regeneration in the peripheral nervous system. Human molecular genetics, 20(12), 2406-2421. https://doi.org/10.1093/hmg/ddr147

Apolipoprotein E (apoE) is a 34 kDa glycoprotein with three distinct isoforms in the human population (apoE2, apoE3 and apoE4) known to play a major role in differentially influencing risk to, as well as outcome from, disease and injury in the centra... Read More about ApoE isoform-specific regulation of regeneration in the peripheral nervous system.