All Outputs (63)

2235 National Trends in motor neurone disease-associated mortality from 1999–2020 (2024)
Journal Article
Imantalab, D., Sokhal, B., Menon, S., Kara, S., Muller, S., & Mallen, C. (2024). 2235 National Trends in motor neurone disease-associated mortality from 1999–2020. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.074

Introduction Motor Neurone Disease (MND) is a neurodegenerative condition affecting the spinal cord and brainstem, commonly associated with a reduced life expectancy. This study describes demographic trends in MND-associated mortality in the United S... Read More about 2235 National Trends in motor neurone disease-associated mortality from 1999–2020.

2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study (2024)
Journal Article
Sokhal, B., Menon, S., Shepherd, T., Muller, S., Arora, A., & Mallen, C. (2024). 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study. Age and ageing, 53(Supplement_3), iii19. https://doi.org/10.1093/ageing/afae139.073

Introduction Parkinson’s disease (PD) is the most common neurodegenerative movement disorder and is associated with significant disability. The prevalence of PD is increasing and the literature demonstrates potential sex and race disparities in patie... Read More about 2234 Temporal trends in Parkinson’s disease-related mortality from 1999–2020: a Nationwide cohort study.

2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients (2024)
Journal Article
Sokhal, B., Matetić, A., Protheroe, J., Helliwell, T., Myint, P., Paul, T., …Mamas, M. (2024). 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients. Age and ageing, 53(Supplement_3), https://doi.org/10.1093/ageing/afae139.051

Introduction Data are limited on whether the causes of Emergency Department (ED) attendance and clinical outcomes vary by frailty status. Methods Using data from the Nationwide Emergency Department Sample, all ED attendances from 2016 to 2018 were st... Read More about 2236 Emergency department attendance stratified by cause and frailty status: a national cohort study of over 155 million patients.

Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study. (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study. The Lancet Rheumatology, 6(9), e615-e624. https://doi.org/10.1016/S2665-9913%2824%2900128-0

People with immune-mediated inflammatory disease are at increased risk of pneumococcal pneumonia. The effectiveness of pneumococcal vaccination in people with immune-mediated inflammatory diseases has not been evaluated. We investigated the effective... Read More about Effectiveness of pneumococcal vaccination in adults with common immune-mediated inflammatory diseases in the UK: a case-control study..

Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection (2024)
Journal Article
Woodcock, C., Cornwall, N., Harrisson, S., Jinks, C., Buttery, A., Ashworth, J., …Dikomitis, L. (2024). Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection. British Journal of Pain, https://doi.org/10.1177/204946372412540

Introduction Understanding patients’ experiences is important when developing interventions for people living with persistent pain. Interviews and focus groups are frequently used to capture beliefs, views, and perspectives. These methods often requi... Read More about Hearing the patient voice for persistent pain intervention development: Recommendations for using a bespoke online discussion forum for qualitative data collection.

Using Twitter (X) to mobilise knowledge for First Contact Physiotherapists: A qualitative study (Preprint) (2024)
Journal Article
Campbell, L., Quicke, J., Stevenson, K., Paskins, Z., Dziedzic, K., & Swaithes, L. (2024). Using Twitter (X) to mobilise knowledge for First Contact Physiotherapists: A qualitative study (Preprint). Journal of Medical Internet Research, 26, Article e55680. https://doi.org/10.2196/55680

Background: Twitter (now X) is a virtual social network commonly used by healthcare professionals. Little is known about whether it helps healthcare professionals to share, mobilise and co-create knowledge, or reduce the time between research know... Read More about Using Twitter (X) to mobilise knowledge for First Contact Physiotherapists: A qualitative study (Preprint).

Relationship between research activity and general practice performance: cross sectional and longitudinal analyses. (2024)
Journal Article
Gibson, J., Kontopantelis, E., Sutton, M., Boaz, A., Little, P., Mallen, C. D., …Bower, P. (in press). Relationship between research activity and general practice performance: cross sectional and longitudinal analyses. British Journal of General Practice (BJGP), BJGP.2024.0111. https://doi.org/10.3399/BJGP.2024.0111

Research activity usually improves outcomes by being translated into practice. However, there is developing evidence that research activity itself may improve the overall performance of health care organisations. However, evidence that these relation... Read More about Relationship between research activity and general practice performance: cross sectional and longitudinal analyses..

Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study (2024)
Journal Article
Bullock, L., Manning, F., Hawarden, A., Fleming, J., Leyland, S., Clark, E. M., …Paskins, Z. (in press). Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study. Archives of Osteoporosis, 19(1), Article 50. https://doi.org/10.1007/s11657-024-01410-6

Summary Interviews and focus groups with patients, FLS clinicians, and GPs identified challenges relating to clinical and shared decision-making about bone health and osteoporosis medicines. Findings will inform the development of the multicomponent... Read More about Exploring practice and perspectives on shared decision-making about osteoporosis medicines in Fracture Liaison Services: the iFraP development qualitative study.

Exploring GPs' views on beta-blocker prescribing for people with anxiety disorders: a qualitative study. (2024)
Journal Article
Archer, C., Kessler, D., Wiles, N., Chew-Graham, C. A., & Turner, K. (2024). Exploring GPs' views on beta-blocker prescribing for people with anxiety disorders: a qualitative study. British Journal of General Practice (BJGP), Article BJGP.2024.0091. https://doi.org/10.3399/BJGP.2024.0091

Between 2003-2018, incident prescriptions of beta-blockers for anxiety increased substantially, particularly in young adults. NICE guidance for anxiety does not recommend beta-blockers, probably due to a lack of evidence to support such use. Recent r... Read More about Exploring GPs' views on beta-blocker prescribing for people with anxiety disorders: a qualitative study..

Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study (2024)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Mallen, C. D., Nguyen Van-Tam, J. S., & Abhishek, A. (2024). Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study. BMJ Open Gastroenterology, 11(1), Article e001370. https://doi.org/10.1136/bmjgast-2024-001370

Objective: To investigate (1) the UK-wide inactivated influenza vaccine (IIV) uptake in adults with inflammatory bowel disease (IBD), (2) the association between vaccination against influenza and IBD flare and (3) the effectiveness of IIV in preventi... Read More about Uptake, safety and effectiveness of inactivated influenza vaccine in inflammatory bowel disease: a UK-wide study.

2023 EULAR classification criteria for hand osteoarthritis. (2024)
Journal Article
Haugen, I. K., Felson, D. T., Abhishek, A., Berenbaum, F., Bierma-Zeinstra, S., Dziedzic, K. S., …Kloppenburg, M. (in press). 2023 EULAR classification criteria for hand osteoarthritis. Annals of the Rheumatic Diseases, https://doi.org/10.1136/ard-2023-225073

The objective of this study is to develop classification criteria for overall hand osteoarthritis (OA), interphalangeal OA and thumb base OA based on self-reported data and radiographic features. The classification criteria sets were developed in thr... Read More about 2023 EULAR classification criteria for hand osteoarthritis..

NIHR Race Equality Framework: development of a tool for addressing racial equality in public involvement (2024)
Journal Article
Faluyi, D., Ovseiko, P. V., Dziedzic, K., & Scott, F. (in press). NIHR Race Equality Framework: development of a tool for addressing racial equality in public involvement. Research Involvement and Engagement, 10(1), 44. https://doi.org/10.1186/s40900-024-00569-z

Background: While there has been a long recognition of the importance of race equality in health and care research, there is a lack of sustained action among research funding and research performing organisations to address racial equality in public... Read More about NIHR Race Equality Framework: development of a tool for addressing racial equality in public involvement.

Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review] (2024)
Journal Article
Twohig, H., Bajpai, R., Corp, N., Faux-Nightingale, A., Mallen, C., Robinson, T., …Burton, C. (2024). Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review]. NIHR Open Research, 4(22), https://doi.org/10.3310/nihropenres.13549.1

Background Children and young people (CYP) may experience prolonged symptoms following COVID-19, commonly termed ‘Long-COVID’. The characteristics of Long-COVID in CYP are unclear, as are the sequalae of acute COVID-19. We aimed to systematically sy... Read More about Long-term outcomes of COVID-19 infection in children and young people: a systematic review and meta-analysis [version 1; peer review: awaiting peer review].

Impact of research activity on performance of general practices: a qualitative study. (2024)
Journal Article
Kenning, C., Usher-Smith, J. A., Jamison, J., Jones, J., Boaz, A., Little, P., …Park, S. (in press). Impact of research activity on performance of general practices: a qualitative study. British Journal of General Practice Open (BJGP Open), Article BJGPO.2024.0073. https://doi.org/10.3399/BJGPO.2024.0073

There is evidence that engaging in research is directly associated with better performance. If this relationship is to be strengthened, it is necessary to understand the mechanisms which might underlie that relationship. To explore the perspectives o... Read More about Impact of research activity on performance of general practices: a qualitative study..

Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. (2024)
Journal Article
Muller, S., Bailey, J., Bajpai, R., Helliwell, T., Harrisson, S. A., Whittle, R., …Ashworth, J. (in press). Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study. PAIN, https://doi.org/10.1097/j.pain.0000000000003239

Growing evidence from pharmacovigilance data and postmortem toxicology reports highlights the misuse potential of gabapentinoids. This study aimed to investigate the risk of serious adverse outcomes (drug misuse, overdose, major trauma), and their ri... Read More about Risk of adverse outcomes during gabapentinoid therapy and factors associated with increased risk in UK primary care using the clinical practice research datalink: a cohort study..

An evaluation of a public partnership project between academic institutions and young people with Black African, Asian and Caribbean heritage (2024)
Journal Article
Moult, A., Knight, N., Medina, N., Babatunde, O., Kingstone, T., Duffy, H., …Dziedzic, K. (in press). An evaluation of a public partnership project between academic institutions and young people with Black African, Asian and Caribbean heritage. Research Involvement and Engagement, 10(1), Article 31. https://doi.org/10.1186/s40900-024-00564-4

Background: This project (named Reinvent) aimed to promote Public Involvement (PI) in health research. Academics worked with a community group, the Eloquent Praise & Empowerment Dance Company, to develop a community partnership with young people from... Read More about An evaluation of a public partnership project between academic institutions and young people with Black African, Asian and Caribbean heritage.

Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases (2024)
Journal Article
Fuller, A., Hancox, J., Williams, H. C., Card, T., Taal, M. W., Aithal, G. P., …Abhishek, A. (2024). Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases. Rheumatology, Article keae175. https://doi.org/10.1093/rheumatology/keae175

To explore the acceptability of an individualised risk-stratified approach to monitoring for target-organ toxicity in adult patients with immune-mediated inflammatory diseases established on immune-suppressing treatment(s). Adults (≥18 years) taking... Read More about Patient and health professional views on risk-stratified monitoring of immune-suppressing treatment in adults with inflammatory diseases.

Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study (2024)
Journal Article
Hay, C. A., Packham, J., Prior, J. A., Mallen, C. D., & Ryan, S. (2024). Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study. Rheumatology International, 44, 863–884. https://doi.org/10.1007/s00296-024-05554-z

Diagnosis of axial spondyloarthritis (axSpA) is frequently delayed for years after symptom onset. However, little is known about patient and healthcare professional (HCP) perspectives on barriers and facilitators in axSpA diagnosis. This study explor... Read More about Barriers and facilitators in diagnosing axial spondyloarthritis: a qualitative study.

A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. (2024)
Journal Article
Bullock, L., Nicholls, E., Cherrington, A., Butler-Walley, S., Clark, E. M., Fleming, J., …Paskins, Z. (2024). A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol. NIHR Open Research, 4(14), 14. https://doi.org/10.3310/nihropenres.13571.1

BackgroundGood quality shared decision-making (SDM) conversations involve people with, or at risk of osteoporosis and clinicians collaborating to decide, where appropriate, which evidence-based medicines best fit the person's life, beliefs, and value... Read More about A person-centred consultation intervention to improve shared decision-making about, and uptake of, osteoporosis medicines (iFraP): a pragmatic, parallel-group, individual randomised controlled trial protocol..

Evidence-informed recommendations on managing breast screening atypia: perspectives from an expert panel consensus meeting reviewing results from the Sloane atypia project (2023)
Journal Article
Freeman, K., Mansbridge, A., Stobart, H., Clements, K., Wallis, M. G., Pinder, S. E., …Taylor-Phillips, S. (2023). Evidence-informed recommendations on managing breast screening atypia: perspectives from an expert panel consensus meeting reviewing results from the Sloane atypia project. British Journal of Radiology, https://doi.org/10.1093/bjr/tqad053