The parent, the child with Down syndrome and the NHS: A long term relationship
(2023)
Journal Article
Shiner, N. (2023). The parent, the child with Down syndrome and the NHS: A long term relationship. Journal of Medical Imaging and Radiation Sciences, 54(4), S19-S24. https://doi.org/10.1016/j.jmir.2023.09.020
All Outputs (63)
Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo (2023)
Journal Article
Nafchi, N., Chilcott, E., Owen, S., Fuller, H., Bowerman, M., & Yáñez-Muñoz, R. (2023). Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo. Gene Therapy, 30, 812–825. https://doi.org/10.1038/s41434-023-00406-0Spinal muscular atrophy (SMA) is a neuromuscular disease particularly characterised by degeneration of ventral motor neurons. Survival motor neuron (SMN) 1 gene mutations cause SMA, and gene addition strategies to replace the faulty SMN1 copy are a t... Read More about Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo.
Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database (2023)
Journal Article
Swain, S., Coupland, C., Sarmanova, A., Kuo, C. F., Mallen, C., Doherty, M., & Zhang, W. (2023). Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database. British Journal of General Practice (BJGP), 73(733), e615-e622. https://doi.org/10.3399/BJGP.2022.0419The burden of osteoarthritis (OA) in UK primary care has not been investigated thoroughly. To estimate healthcare use and mortality in people with OA (overall and joint specific). A matched cohort study of adults with an incident diagnosis of OA in p... Read More about Healthcare utilisation and mortality in people with osteoarthritis in the UK: findings from a national primary care database.
Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis (2023)
Journal Article
Jinks, C., Campbell, L., Croft, P., Dziedzic, K., Grossman, H., Maddison, J., …Cottrell, L. (2023). Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis. Osteoarthritis and Cartilage, 31(5), 711-712. https://doi.org/10.1016/j.joca.2023.02.064Purpose: Osteoarthritis (OA) is a major cause of pain and disability worldwide. Despite this and the existence of evidence-based guidelines, many patients and professionals lack clarity about the nature of OA and effective treatment strategies. Healt... Read More about Thinking differently: evidence on what patients want and need in an explanation about osteoarthritis.
Management of systemic sclerosis: British Society for Rheumatology guideline scope (2023)
Journal Article
Denton, C. P., De Lorenzis, E., Roblin, E., Goldman, N., Alcacer-Pitarch, B., Blamont, E., …Ong, V. (2023). Management of systemic sclerosis: British Society for Rheumatology guideline scope. Rheumatology Advances in Practice, 7(1), https://doi.org/10.1093/rap/rkad022AbstractThis guideline will provide a practical roadmap for management of SSc that builds upon the previous treatment guideline to incorporate advances in evidence-based treatment and increased knowledge about assessment, classification and managemen... Read More about Management of systemic sclerosis: British Society for Rheumatology guideline scope.
Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice (2022)
Journal Article
Schreiber, K., Frishman, M., Russell, M. D., Dey, M., Flint, J., Allen, A., …Williams, E. (2023). Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice. Rheumatology, 62(4), 1388-1397. https://doi.org/10.1093/rheumatology/keac559
Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids (2022)
Journal Article
Russell, M. D., Dey, M., Flint, J., Davie, P., Allen, A., Crossley, A., …Williams, E. (2023). Executive Summary: British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: immunomodulatory anti-rheumatic drugs and corticosteroids. Rheumatology, 62(4), 1370-1387. https://doi.org/10.1093/rheumatology/keac558
British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice (2022)
Journal Article
Schreiber, K., Frishman, M., Russell, M. D., Dey, M., Flint, J., Allen, A., …Williams, E. (2023). British Society for Rheumatology guideline on prescribing drugs in pregnancy and breastfeeding: comorbidity medications used in rheumatology practice. Rheumatology, 62(4), e89-e104. https://doi.org/10.1093/rheumatology/keac552
Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum (2021)
Journal Article
Nakafero, G., Grainge, M. J., Card, T., Taal, M. W., Aithal, G. P., Zhang, W., …Abhishek, A. (2022). Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum. Rheumatology, 61(7), 2783–2791. https://doi.org/10.1093/rheumatology/keab790OBJECTIVE: To develop and validate a prognostic model for leflunomide discontinuation with abnormal blood-test results. METHODS: Data from CPRD Gold and Aurum were used for model development and external validation respectively. Participants prescrib... Read More about Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.
A Review of Zoonotic Infection Risks Associated with the Wild Meat Trade in Malaysia (2017)
Journal Article
Cantlay, J., Ingram, D., & Meredith, A. (2017). A Review of Zoonotic Infection Risks Associated with the Wild Meat Trade in Malaysia. EcoHealth, 14(2), 361–388. https://doi.org/10.1007/s10393-017-1229-xThe overhunting of wildlife for food and commercial gain presents a major threat to biodiversity in tropical forests and poses health risks to humans from contact with wild animals. Using a recent survey of wildlife offered at wild meat markets in Ma... Read More about A Review of Zoonotic Infection Risks Associated with the Wild Meat Trade in Malaysia.
A nurse-led clinic for patients consulting with osteoarthritis in general practice: development and impact of training for its delivery in the MOSAICS study. (2016)
Journal Article
Healey, E. L., Main, C. J., Ryan, S., McHugh, G. A., Porcheret, M., Finney, A. G., …Dziedzic, K. S. (2016). A nurse-led clinic for patients consulting with osteoarthritis in general practice: development and impact of training for its delivery in the MOSAICS study. BMC Family Practice, 17, Article 173Background Despite a lack of service provision for people with osteoarthritis (OA), each year 1 in 5 of the general population consults a GP about a musculoskeletal condition such as OA. Consequently this may provide an opportunity for practice nurs... Read More about A nurse-led clinic for patients consulting with osteoarthritis in general practice: development and impact of training for its delivery in the MOSAICS study..
Improving the care of people with long-term conditions in primary care: (2015)
Journal Article
Healey, E. L., Jinks, C., Tan, V. A., Chew-Graham, C. A., Lawton, S. A., Nicholls, E., …Mallen, C. D. (2015). Improving the care of people with long-term conditions in primary care:. Journal of Comorbidity, 2015(5), 135-149. https://doi.org/10.15256/joc.2015.5.60Background Long-term conditions (LTCs) are important determinants of quality of life and healthcare expenditure worldwide. Whilst multimorbidity is increasingly the norm in primary care, clinical guidelines and the delivery of care remain focused on... Read More about Improving the care of people with long-term conditions in primary care:.
USE OF AN OSTEOARTHRITIS GUIDEBOOK TO HELP PROVIDE SUPPORTED SELF-MANAGEMENT IN PRIMARY CARE: A QUALITATIVE EXPLORATION OF ACCEPTABILITY FOR PATIENTS AND PROFESSIONALS (2014)
Journal Article
Morden, A., Jinks, C., Nio Ong, B., Porcheret, M., & Dziedzic, K. (2014). USE OF AN OSTEOARTHRITIS GUIDEBOOK TO HELP PROVIDE SUPPORTED SELF-MANAGEMENT IN PRIMARY CARE: A QUALITATIVE EXPLORATION OF ACCEPTABILITY FOR PATIENTS AND PROFESSIONALS. https://doi.org/10.1093/rheumatology/keu099.001
OP0152-PC Knowledge and Confidence of Practice Nurses in the Management of Osteoarthritis (OA): Pre- and Post-Evaluation of an OA Self-Management Training Programme (2014)
Journal Article
Healey, E. L., Ryan, S., McHugh, G. A., Main, C. J., Porcheret, M., Ong, B. N., …Dziedzic, K. S. (2014). OP0152-PC Knowledge and Confidence of Practice Nurses in the Management of Osteoarthritis (OA): Pre- and Post-Evaluation of an OA Self-Management Training Programme. Annals of the Rheumatic Diseases, 72(Suppl 3), A103.3-A104. https://doi.org/10.1136/annrheumdis-2013-eular.357Background In the United Kingdom (UK), practice nurses do not routinely consult with individuals with OA as most OA care is provided by general practitioners. However, evidence suggests that practice nurses are most likely to provide self-management... Read More about OP0152-PC Knowledge and Confidence of Practice Nurses in the Management of Osteoarthritis (OA): Pre- and Post-Evaluation of an OA Self-Management Training Programme.
Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice (2013)
Journal Article
Clarson, L. E., Nicholl, B. I., Bishop, A., Edwards, J., Daniel, R., & Mallen, C. (2013). Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice. Quality in Primary Care, 21(2), 97-103BackgroundDespite being a chronic condition with a high prevalence and significant associated morbidity that is managed predominantly in primary care, osteoarthritis (OA) does not feature in the Quality and Outcomes Framework (QOF) component of theUK... Read More about Should there be a Quality and Outcomes Framework domain for osteoarthritis? A cross-sectional survey in general practice.
MAGNETIC NANOPARTICLE MEDIATED GENE DELIVERY IN OLIGODENDROGLIAL CELLS: A COMPARISON OF DIFFERENTIATED CELLS VERSUS PRECURSOR FORMS (2012)
Journal Article
JENKINS, S. I., PICKARD, M. R., & CHARI, D. M. (2013). MAGNETIC NANOPARTICLE MEDIATED GENE DELIVERY IN OLIGODENDROGLIAL CELLS: A COMPARISON OF DIFFERENTIATED CELLS VERSUS PRECURSOR FORMS. Nano LIFE, 03(02), Article 1243001. https://doi.org/10.1142/s1793984412430015Magnetic nanoparticles (MNPs) have emerged as a major platform for the formulation of magnetic vectors for nonviral gene delivery. Notably the application of "magnetofection" strategies (use of magnetic fields to increase MNP–cell interactions) can s... Read More about MAGNETIC NANOPARTICLE MEDIATED GENE DELIVERY IN OLIGODENDROGLIAL CELLS: A COMPARISON OF DIFFERENTIATED CELLS VERSUS PRECURSOR FORMS.
Transcriptional effects of corticosteroid therapy on myelin genesis and neuronal health (2011)
Journal Article
Chari, D. (2011). Transcriptional effects of corticosteroid therapy on myelin genesis and neuronal health. Midlands Medicine, 26(3),
Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies (2011)
Journal Article
Yiu, H. H. P., Pickard, M. R., Olariu, C. I., Williams, S. R., Chari, D. M., & Rosseinsky, M. J. (2012). Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies. Pharmaceutical Research, 29(5), 1328-1343. https://doi.org/10.1007/s11095-011-0632-1Purpose To develop Fe3O4-PEI-RITC magnetic nanoparticles with multimodal MRI-fluorescence imaging and transfection capability, for use in neural cell replacement therapies. Methods The Fe3O4-PEI-RITC MNPs were synthesised through a multi-step ch... Read More about Fe3O4-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies.
Current research on SMN protein and treatment strategies for spinal muscular atrophy (2011)
Journal Article
Humphrey, E., Fuller, H. R., & Morris, G. E. (2012). Current research on SMN protein and treatment strategies for spinal muscular atrophy. Neuromuscular Disorders, 22(2), 193-197. https://doi.org/10.1016/j.nmd.2011.06.002
Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies (2011)
Journal Article
Jenkins, S. I., Pickard, M. R., Granger, N., & Chari, D. M. (2011). Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies. ACS Nano, 5(8), 6527-6538. https://doi.org/10.1021/nn2018717This study has tested the feasibility of using physical delivery methods, employing static and oscillating field “magnetofection” techniques, to enhance magnetic nanoparticle-mediated gene transfer to rat oligodendrocyte precursor cells derived for t... Read More about Magnetic Nanoparticle-Mediated Gene Transfer to Oligodendrocyte Precursor Cell Transplant Populations Is Enhanced by Magnetofection Strategies.