All Outputs (2087)

Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites (2023)
Journal Article

Background High–molecular weight kininogen (HK) circulates in plasma as a complex with zymogen prekallikrein (PK). HK is both a substrate and a cofactor for activated plasma kallikrein, and the principal exosite interactions occur between PK N-termi... Read More about Structures of factor XI and prekallikrein bound to domain 6 of high–molecular weight kininogen reveal alternate domain 6 conformations and exosites.

Demographic characteristics influencing the stem subsidence in total hip arthroplasty: an imaging study. (2023)
Journal Article

The present study evaluated whether patient demographic characteristics influence the subsidence of the stem in total hip arthroplasty (THA). The following characteristics were evaluated: age, height, weight, and sex. The association between the time... Read More about Demographic characteristics influencing the stem subsidence in total hip arthroplasty: an imaging study..

Graphical Abstract in Scientific Research. (2023)
Journal Article

A graphical abstract (GA) summarizes the key and important findings of an article graphically, potentially stimulating researchers to view the published manuscript. A GA should enhance dissemination, augment engagement, and impact clinical practice.... Read More about Graphical Abstract in Scientific Research..

Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review (2023)
Journal Article

Total hip arthroplasty (THA) is a successful orthopaedic surgical procedure, and its longevity depends on bearing components and implant fixation. Optimizing polyethylene and ceramics has led to improved wear parameters and contributed to improved lo... Read More about Risk factors for liner wear and head migration in total hip arthroplasty: a systematic review.

THE KYNURENINE PATHWAY AND ITS ROLE IN GLIOBLASTOMA CELL MIGRATION (2023)
Journal Article

AIMS The kynurenine (Kyn) pathway plays an important role in the pathogenesis of many cancers including glioblastomas (GBMs). The enzymes, indoleamine-2,3-dioxygenase (IDO1) and tryptophan-2,3-dioxygenase (TDO2), regulate the first and rate-limiting... Read More about THE KYNURENINE PATHWAY AND ITS ROLE IN GLIOBLASTOMA CELL MIGRATION.

Iron oxide nanoparticles as a new tool for treating cardiovascular diseases (2023)
Conference Proceeding

Thrombotic events are a major cause of death and disability worldwide. Thrombolysis with the clot busting drug tissue plasminogen activator (tPA) or thromboprophylaxis using anticoagulants such as heparin are frontline treatments for thrombotic disea... Read More about Iron oxide nanoparticles as a new tool for treating cardiovascular diseases.

Subtalar joint axis alignments in pathological feet of children with cerebral palsy (2023)
Journal Article

Introduction Children suffering cerebral palsy (CP) often develop foot deformities [1]. These manifest as pathological postures including equinovarus, planovalgus non-midfoot break (PNMFB) and midfoot break (MFB)... Read More about Subtalar joint axis alignments in pathological feet of children with cerebral palsy.

Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm (2023)
Journal Article

Introduction Facioscapulohumeral dystrophy (FSHD) can affect upper-limb function through muscle degeneration, fatty infiltration and oedema. Muscle echogenicity, measured using ultrasound, could be used as a bioma... Read More about Quantifying morphological changes in middle trapezius with ultrasound scanning and a novel histogram matching algorithm.

Subtalar joint moments of children with cerebral palsy (2023)
Journal Article

Introduction Children with cerebral palsy (CP) often develop foot deformities [1], such as equinovarus, planovalgus non-midfoot break (PNMFB) and midfoot break (MFB) [2]. The aetiology of the development and progr... Read More about Subtalar joint moments of children with cerebral palsy.

Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. (2023)
Journal Article

Healthy synovium is critical for joint homeostasis. Synovial inflammation (synovitis) is implicated in the onset, progression and symptomatic presentation of arthritic joint diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Thus, th... Read More about Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment..

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair (2023)
Journal Article

Tendons are dense connective tissues with a hierarchical polarized structure that respond to and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion and maintaining posture. Tendon injuries, also known as tendinopa... Read More about Tendon tissue engineering: An overview of biologics to promote tendon healing and repair.

Evaluating the use of electromyography in UK and european gait laboratories for the assessment of cerebral palsy and neurological conditions (2023)
Journal Article

Introduction Electromyography (EMG) can estimate the magnitude and timing of muscle activation during walking in those with neurological gait disorders. Despite the potential of EMG use in assessment and clinical... Read More about Evaluating the use of electromyography in UK and european gait laboratories for the assessment of cerebral palsy and neurological conditions.

Percutaneous cruciate repair of ruptured Achilles tendon (2023)
Journal Article

Percutaneous repair is a safe and reliable method to restore continuity after acute Achilles tendon ruptures, with a lower incidence of wound complications compared to open techniques. We describe a novel percutaneous cruciate suture performed throug... Read More about Percutaneous cruciate repair of ruptured Achilles tendon.

Evaluation of the introduction of a synchronous online induction for postgraduate diploma students. (2023)
Presentation / Conference

Background: A previous qualitative study identified the need for postgraduate clinical diploma distance-learning students to have a synchronous induction.(O’Byrne,2022) An induction session was created, starting in January 2022 for each new cohor... Read More about Evaluation of the introduction of a synchronous online induction for postgraduate diploma students..

Analysis of Synovial Fluid Proteomes After Treating an Ovine Osteoarthritic Model with Human Umbilical Cord Mesenchymal Stem Cells (2023)
Presentation / Conference

TENDINopathy Severity Assessment – Achilles (TENDINS-A): Development and Content Validity Assessment of a New Patient-Reported Outcome Measure for Achilles Tendinopathy (2023)
Journal Article

OBJECTIVE: To develop a new patient-reported outcome measure (PROM) assessing TENDINopathy Severity of the Achilles (TENDINS-Achilles) and evaluate its content validity. DESIGN: Mixed-methods, modified Delphi. METHODS: We performed 1 round of s... Read More about TENDINopathy Severity Assessment – Achilles (TENDINS-A): Development and Content Validity Assessment of a New Patient-Reported Outcome Measure for Achilles Tendinopathy.

Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy (2023)
Journal Article

Background: Treatment decisions for cartilage defects are often based on lesion size. Magnetic resonance imaging (MRI) is widely used to diagnose cartilage defects noninvasively; however, their size estimated from MRI may differ from defect sizes me... Read More about Comparison of Knee Articular Cartilage Defect Size Between Measurements Obtained on Preoperative MRI Versus During Arthrotomy.

Small interfering RNAs in the management of human osteoporosis (2023)
Journal Article

Background Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies. Sources of data A systemat... Read More about Small interfering RNAs in the management of human osteoporosis.

Pharmacological agents for bone fracture healing: talking points from recent clinical trials (2023)
Journal Article

Introduction Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fractu... Read More about Pharmacological agents for bone fracture healing: talking points from recent clinical trials.

Developing consensus on the principles and key actions for collaborative working between general practices and community pharmacies: a modified eDelphi study (2023)
Journal Article

Objectives: To develop consensus on the principles and key actions for collaborative working in practice between general practice, community pharmacy and patients and their carers. Design: Three-round modified eDelphi study, starting from an esta... Read More about Developing consensus on the principles and key actions for collaborative working between general practices and community pharmacies: a modified eDelphi study.