All Outputs (447)

The Effect of Early Resistance Training Combined With Aerobic Training Versus Aerobic Training Alone on Functional Capacity Following Rheumatic Fever-Related Valve Replacement Surgery: A Randomised Controlled Trial (2025)
Presentation / Conference Contribution
Pengelly, J., Atef, H., Helmy, Z., Buckley, J., Bahjat, M., Nagy, E., & El-Ansary, D. (2025, August). The Effect of Early Resistance Training Combined With Aerobic Training Versus Aerobic Training Alone on Functional Capacity Following Rheumatic Fever-Related Valve Replacement Surgery: A Randomised Controlled Trial. Presented at 73rd Annual Scientific Meeting ofthe Cardiac Society of Australia and New Zealand, Brisbane, Queensland, Australia

Aim
To determine the effect of early resistance training combined with aerobic training (RTAerobic) in Phase I Cardiac Rehabilitation (CR) on functional capacity, P-R interval, and resting heart rate (RHR), compared to aerobic training alone (Aerobi... Read More about The Effect of Early Resistance Training Combined With Aerobic Training Versus Aerobic Training Alone on Functional Capacity Following Rheumatic Fever-Related Valve Replacement Surgery: A Randomised Controlled Trial.

Early Balance Training Combined With Phase I Cardiac Rehabilitation Following Coronary Artery Bypass Grafting: A Randomised Controlled Trial Examining the Effects on Balance, Strength and Post-Operative Recovery (2025)
Presentation / Conference Contribution
Pengelly, J., Atef, H., Maged, A., Ali, H., & El Ghaffar, H. (2025, August). Early Balance Training Combined With Phase I Cardiac Rehabilitation Following Coronary Artery Bypass Grafting: A Randomised Controlled Trial Examining the Effects on Balance, Strength and Post-Operative Recovery. Presented at 73rd Annual Scientific Meeting ofthe Cardiac Society of Australia and New Zealand, Brisbane, Queensland, Australia

Aim
To determine whether balance training combined with Phase I CR improved balance, strength, hospital length of stay (LOS) and quality of life (QoL) in post-coronary artery bypass grafting (CABG) patients beyond Phase I cardiac rehabilitation (CR)... Read More about Early Balance Training Combined With Phase I Cardiac Rehabilitation Following Coronary Artery Bypass Grafting: A Randomised Controlled Trial Examining the Effects on Balance, Strength and Post-Operative Recovery.

Health among Retired Great Britain’s Olympic Athletes: A cross-sectional Study of Disease and Multimorbidity (2025)
Journal Article
Cooper, D. J., & Sim, J. (2025). Health among Retired Great Britain’s Olympic Athletes: A cross-sectional Study of Disease and Multimorbidity. Sports Medicine - Open, 11(1), Article 93. https://doi.org/10.1186/s40798-025-00897-8

Background: Currently, there is a paucity of long-term health data for retired athletes. This study describes the prevalence of common morbidities and multimorbidity among retired Great Britain’s (GB) Olympic athletes, compared to a general populatio... Read More about Health among Retired Great Britain’s Olympic Athletes: A cross-sectional Study of Disease and Multimorbidity.

BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial (2025)
Journal Article
Davies, S. J., Coyle, D., Lindley, E., Keane, D., Belcher, J., Caskey, F., Dasgupta, I., Davenport, A., Farrington, K., Mitra, S., Ormandy, P., Wilkie, M., MacDonald, J., Zanganeh, M., Andronis, L., Solis-Trapala, I., & Sim, J. (2025). BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial. Health Technology Assessment, 29(32), 1-23. https://doi.org/10.3310/rhon2378

Background Fluid removal is a key component of dialysis treatment but, if excessive, can result in a faster decline in residual kidney function. Prescribing the optimal removal of fluid on dialysis to avoid this is therefore important. Bioimpedance s... Read More about BioImpedance Spectroscopy to maintain Renal Output: the BISTRO randomised controlled trial.

Astrocyte-Conditioned Medium Induces Protection Against Ischaemic Injury in Primary Rat Neurons (2025)
Journal Article
Singh, A., & Chen, R. (in press). Astrocyte-Conditioned Medium Induces Protection Against Ischaemic Injury in Primary Rat Neurons. Neuroglia, 6(3), Article 27. https://doi.org/10.3390/neuroglia6030027

Background: Astrocytes are not only structural cells but also play a pivotal role in neurogenesis and neuroprotection by secreting a variety of neurotrophic factors that support neuronal survival, growth, and repair. This study investigates the time-... Read More about Astrocyte-Conditioned Medium Induces Protection Against Ischaemic Injury in Primary Rat Neurons.

Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey (2025)
Journal Article
O'Brien, A. V., Muller, S., Liddle, J., Thomas, M. J., & Mallen, C. D. (2025). Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey. Musculoskeletal Care, 23(3), Article e70155. https://doi.org/10.1002/msc.70155

Introduction: Polymyalgia rheumatica (PMR) international management guidelines advocate patient education and individualised exercises but lack evidence and physiotherapy practice for PMR is unknown. PMR is typically treated with glucocorticoids, but... Read More about Physiotherapy for the Management of Polymyalgia Rheumatica: Results From a UK Cross‐Sectional Survey.

Effects of threshold inspiratory muscle trainer versus trigger sensitivity adjustment versus conventional therapy on respiratory function in mechanically ventilated patients: a randomized controlled trial. (2025)
Journal Article
Abdeen, H. A., Atef, H., Elnahas, N. G., Khalaf, O. A., Soliman, Y. M., Elkorashy, R. I., Mowad, S., Moreno-Segura, N., Carrasco, J. J., & Marques-Sule, E. (2025). Effects of threshold inspiratory muscle trainer versus trigger sensitivity adjustment versus conventional therapy on respiratory function in mechanically ventilated patients: a randomized controlled trial. Respiratory Physiology and Neurobiology, 337, Article 104469. https://doi.org/10.1016/j.resp.2025.104469

Background
Prolonged mechanical ventilation in chronic obstructive pulmonary disease is associated with severe complications, and then earlier weaning is desirable. Then, strategies such as inspiratory muscle trai... Read More about Effects of threshold inspiratory muscle trainer versus trigger sensitivity adjustment versus conventional therapy on respiratory function in mechanically ventilated patients: a randomized controlled trial..

Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review] (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S. A., Woodcock, C., Nicholls, E., Hughes, G., Marshall, E., Lawton, S. A., Wathall, S., Helliwell, T., Jowett, S., Avery, A. J., Knaggs, R., Hussain, B., Santer, M., Pincus, T., White, S., Sillitto, C., Jinks, C., & Mallen, C. D. (2025). Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review]. NIHR Open Research, 5(54), https://doi.org/10.3310/nihropenres.13961.1

Background
Addressing the need for evidence-based interventions to reduce opioid use for persistent pain, we developed the PROMPPT intervention (Proactive clinical Review of patients taking Opioid Medicines long-term for persistent Pain led by clini... Read More about Evaluating a primary care pharmacist-led intervention to reduce opioid use for persistent non-cancer pain: the PROMPPT cluster randomised controlled trial protocol [version 1; peer review: awaiting peer review].

Development and validation of a symptom assessment instrument for advanced chronic kidney disease (2025)
Thesis
Pugh-Clarke, K. (2025). Development and validation of a symptom assessment instrument for advanced chronic kidney disease. (Thesis). Keele University. https://keele-repository.worktribe.com/output/1280032

Background
Patients with advanced chronic kidney disease (CKD), not on renal replacement therapy (RRT), may have a significant symptom burden, which may negatively impact on health related quality of life (QoL). Accordingly, proactive symptom manag... Read More about Development and validation of a symptom assessment instrument for advanced chronic kidney disease.

Thieno[2,3-b]pyridine compounds potently inhibit prostate cancer growth and motility (2025)
Journal Article
Alkheilewi, M. A., Leach, D. A., Mohr, A., Zwacka, R. M., Laissue, P., Metodiev, M., Bevan, C. L., Van Rensburg, M., Pilkington, L. I., Barker, D., Reynisson, J., Brooke, G. N., Alkheilewi, M. A., Mohr, A., Zwacka, R. M., Laissue, P., Metodiev, M., Van Rensburg, M., Pilkington, L. I., & Reynisson, J. (2025). Thieno[2,3-b]pyridine compounds potently inhibit prostate cancer growth and motility. Endocrine Oncology, 5(1), https://doi.org/10.1530/eo-24-0082

Objective Prostate cancer growth is dependent upon androgens and hence therapies often target this signalling axis. These therapies, for example the antiandrogen enzalutamide, are successful in the majority of men; however, resistance is inevitable a... Read More about Thieno[2,3-b]pyridine compounds potently inhibit prostate cancer growth and motility.

Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa (2025)
Journal Article
Babatunde, O. O., Adetunji, O., Alonge, I., Owoyemi, T., Ayinmode, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., & Dziedzic, K. (2025). Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa. BMJ Global Health, 10(6), Article e018714. https://doi.org/10.1136/bmjgh-2024-018714

To assess the feasibility of a guideline-informed model of care for osteoarthritis in primary healthcare and community pharmacy settings in the West African context. The 4-phase mixed-methods programme of research undertaken in Southwest Nigeria, Wes... Read More about Process and feasibility of implementing guideline recommendations for the care of osteoarthritis in West Africa.

Professional challenges faced by student radiographers during COVID-19. (2025)
Journal Article
McNulty, J. P., Zarnado M, M., Buissink, C., DeCoster, R., Hennessy, W., Knapp, K., Kraus, B., Lanca, L., Lewis, S., Mahlaola Tintswalo, B., McEntee, M., O'Leary, D., Precht, H., Starc, T., & Rainford, L. A. (2025). Professional challenges faced by student radiographers during COVID-19. Radiography, 31(4), 1-10. https://doi.org/10.1016/j.radi.2025.103000

This study aimed to identify the challenges facing radiography students at the peak of the COVID-19 pandemic, document their experiences in mid-2020, and explore supports for resilience-building in educational and clinical contexts. An online survey... Read More about Professional challenges faced by student radiographers during COVID-19..

Unlocking the potential of injectable hydrogels for cartilage repair (2025)
Journal Article
Atwal, A., Mahnavi, A., & Davoodi, P. (2025). Unlocking the potential of injectable hydrogels for cartilage repair. Regenerative Medicine, 20(5), 193-202. https://doi.org/10.1080/17460751.2025.2520708

Osteoarthritis (OA), a prevalent degenerative joint disease, poses significant global health implications and is characterized by progressive degradation of articular cartilage, resulting in debilitating pain and disability. Current treatments often... Read More about Unlocking the potential of injectable hydrogels for cartilage repair.

Exploring user experiences of the National Institute of Health and Care Excellence’s Shared Decision Making learning package: an online qualitative study (2025)
Journal Article
Jacklin, S., Thompson, J., Hutchinson, A., Maddock, K., Maskrey, N., Norburn, L., & Underhill, J. (2025). Exploring user experiences of the National Institute of Health and Care Excellence’s Shared Decision Making learning package: an online qualitative study. BMJ Open, 15(5), 1-8. https://doi.org/10.1136/bmjopen-2024-088856

Objective:
To evaluate the user experience of the joint National Institute of Health and Care Excellence (NICE)/Keele University Shared Decision Making (SDM) learning package.
Design: A qualitative study using online semistructured interviews. Da... Read More about Exploring user experiences of the National Institute of Health and Care Excellence’s Shared Decision Making learning package: an online qualitative study.

Changes in cardiorespiratory economy in people with atrial fibrillation (AF) attending exercise cardiac rehabilitation (2025)
Presentation / Conference Contribution
Buckley, J. P., Gibson, E., Terada, T., Mistura, M., & Reed, J. L. (2025, April). Changes in cardiorespiratory economy in people with atrial fibrillation (AF) attending exercise cardiac rehabilitation. Presented at ESC Preventive Cardiology 2025, Milan, Italy

Background V̇O2 peak is often reported as a main outcome for cardiorespiratory health, fitness and risk. However it is known that improved V̇O2 peak following exercise training can be influenced by such factors as improved motivation, confidence, exe... Read More about Changes in cardiorespiratory economy in people with atrial fibrillation (AF) attending exercise cardiac rehabilitation.

The effect of dance interventions on cardiorespiratory fitness and quality of life of older adults with chronic non-communicable diseases. A systematic review and meta-analysis (2025)
Presentation / Conference Contribution
Kamilova, Z., Buckley, J. P., Paton, B., & Loosemore, M. (2025, April). The effect of dance interventions on cardiorespiratory fitness and quality of life of older adults with chronic non-communicable diseases. A systematic review and meta-analysis. Presented at ESC Preventive Cardiology 2025, Milan, Italy

Background/Introduction According to World Health Organization’s (WHO) Global action plan for the prevention and control of noncommunicable diseases (NCD) 2013-2020 physical inactivity is one of the dominant risk factors for NCDs.(1) AHA recommends b... Read More about The effect of dance interventions on cardiorespiratory fitness and quality of life of older adults with chronic non-communicable diseases. A systematic review and meta-analysis.

Can Azerbaijan national dancing provide a suitable exercise stimulus for heart failure cardiac rehabilitation participants? (2025)
Presentation / Conference Contribution
Kamilova, Z., Paton, B., Loosemore, M., & Buckley, J. P. (2025, April). Can Azerbaijan national dancing provide a suitable exercise stimulus for heart failure cardiac rehabilitation participants?. Presented at ESC Preventive Cardiology 2025, Milan, Italy

Background/Introduction Whilst exercise-based cardiac rehabilitation (CR) has a strong evidence-base there remains a poor uptake and adherence. Global access to cardiac rehabilitation (CR) continues to be low, and even in countries with good CR provi... Read More about Can Azerbaijan national dancing provide a suitable exercise stimulus for heart failure cardiac rehabilitation participants?.

The effectiveness of mulligan mobilization with movement (MWM) on outcomes of patients with ankle sprain: a systematic review and meta-analysis (2025)
Journal Article
ElMeligie, M. M., Abdeen, H. A., Atef, H., Marques-Sule, E., & Karkosha, R. N. (2025). The effectiveness of mulligan mobilization with movement (MWM) on outcomes of patients with ankle sprain: a systematic review and meta-analysis. BMC Sports Science, Medicine and Rehabilitation, 17(1), Article 105. https://doi.org/10.1186/s13102-025-01121-6

Background: Ankle sprains are common injuries that cause pain, swelling, and reduced range of motion (ROM), adversely affecting physical activity. In this study, we aim to review the effectiveness of mobilization with movement (MWM) in improving outc... Read More about The effectiveness of mulligan mobilization with movement (MWM) on outcomes of patients with ankle sprain: a systematic review and meta-analysis.

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.