All Outputs (2)

Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates (2020)
Thesis
Dimitriou, E. (2020). Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates. (Thesis). Keele University

Alginate is an anionic polysaccharide comprised of β˗1,4˗linked D˗mannuronic acid (M) and L˗guluronic acid (G). The polymer is naturally harvested from seaweed and is widely exploited in various biotechnological and biomedical applications, due to th... Read More about Chemical synthesis of modified D-mannuronate building blocks: prospects for modified alginates.

Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa (2020)
Thesis
Beswick, L. E. M. (2020). Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa. (Thesis). Keele University

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic bacterium, responsible for causing life threatening infections amongst fibrosis (CF) patients. Mucoid phenotypes of P. aeruginosa are characterised by overproduction of alginate, an extra-cel... Read More about Chemoenzymatic synthesis of sugar-nucleotide analogues: tools to probe a strategic dehydrogenase from Pseudomonas aeruginosa.