Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes

Tierney, Lauren Jessica

All Outputs (3)

Characterisation of Bone Marrow Aspirate Concentrate with Thrombin Used for Repairing Osteochondral Lesions of the Talus (2025)
Journal Article
Lan, T., Wright, K. T., Makwana, N., Bing, A., Hulme, C. H., & McCarthy, H. S. (2025). Characterisation of Bone Marrow Aspirate Concentrate with Thrombin Used for Repairing Osteochondral Lesions of the Talus. The Journal of Cartilage & Joint Preservation, Article 100237. https://doi.org/10.1016/j.jcjp.2025.100237

A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation (2024)
Journal Article
Orfanos, G., McCarthy, H. S., Williams, M., Dugard, N., Gallacher, P. D., Glover, A. W., Roberts, S., Wright, K. T., & Kuiper, J. H. (2024). A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation. Cartilage, https://doi.org/10.1177/19476035241279943

Objective
Traditional autologous chondrocyte implantation (ACI) involves arthroscopically harvesting a cartilage biopsy (stage 1), followed by arthrotomy 3-4 weeks later to apply a periosteal patch and implant culture-expanded chondrocytes underneat... Read More about A Randomized Controlled Trial Comparing “Early” Versus “Late” Periosteal Patch Attachment to Knee Chondral Defects in Autologous Chondrocyte Implantation.

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis
Tierney, L. J. Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes. (Thesis). Keele University. https://keele-repository.worktribe.com/output/775433

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.