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Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants (2019)
Journal Article
Mendes, A., Meneghetti, M., Palladino, M., Justo, G., Sassaki, G., Fareed, J., …Nader, H. (2019). Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants. Molecules, 24, 2988--2988. https://doi.org/10.3390/molecules24162988

Nowadays, pharmaceutical heparin is purified from porcine and bovine intestinal mucosa. In the past decade there has been an ongoing concern about the safety of heparin, since in 2008, adverse effects associated with the presence of an oversulfated c... Read More about Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants.

The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro (2019)
Journal Article
(2019). The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro. RSC advances, 24505 - 24518. https://doi.org/10.1039/C9RA03831K

The physicochemical hallmarks of particulate immunopotentiators play a pivotal role with regards to their adjuvanticity in vivo. These properties have not been fully characterised in the case of MCT®, an amino acid-based adjuvant used as an alternati... Read More about The size of micro-crystalline tyrosine (MCT®) influences its recognition and uptake by THP-1 macrophages in vitro.

Anosmic migrating songbirds demonstrate a compensatory response following long-distance translocation: a radio-tracking study (2019)
Journal Article
Kishkinev, D., Anashina, A., Ishchenko, I., & Holland, R. A. (2019). Anosmic migrating songbirds demonstrate a compensatory response following long-distance translocation: a radio-tracking study. Journal of Ornithology, https://doi.org/10.1007/s10336-019-01698-z

Several studies have shown that experienced night-migratory songbirds can determine their position, but it has remained a mystery which cues and sensory mechanisms they use, in particular, those used to determine longitude (east–west position). One p... Read More about Anosmic migrating songbirds demonstrate a compensatory response following long-distance translocation: a radio-tracking study.

Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility (2019)
Journal Article
Silva, A. I., Haddon, J. E., Ahmed Syed, Y., Trent, S., Lin, T. E., Patel, Y., …Wilkinson, L. S. (2019). Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility. Nature communications, 10, Article 3455. https://doi.org/10.1038/s41467-019-11119-7

The biological basis of the increased risk for psychiatric disorders seen in 15q11.2 copy number deletion is unknown. Previous work has shown disturbances in white matter tracts in human carriers of the deletion. Here, in a novel rat model, we recapi... Read More about Cyfip1 haploinsufficient rats show white matter changes, myelin thinning, abnormal oligodendrocytes and behavioural inflexibility.

Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all. (2019)
Journal Article
(2019). Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all. Parasites and Vectors, 377 - ?. https://doi.org/10.1186/s13071-019-3608-3

BACKGROUND: Life history theory predicts that an individual's current reproductive investment should depend on its future reproductive value. A variety of intrinsic biotic and extrinsic factors influence reproductive value, including age, health st... Read More about Current versus future reproductive investment adaptive responses in adult Anopheles coluzzii malaria mosquitoes: hydric-stressed males give it all..

Using drones and sirens to elicit avoidance behaviour in white rhinoceros as an anti-poaching tactic. (2019)
Journal Article
(2019). Using drones and sirens to elicit avoidance behaviour in white rhinoceros as an anti-poaching tactic. Proceedings of the Royal Society B: Biological Sciences, 20191135 - ?. https://doi.org/10.1098/rspb.2019.1135

Poaching fuelled by international trade in horn caused the deaths of over 1000 African rhinoceros (Ceratotherium simum and Diceros bicornis) per year between 2013 and 2017. Deterrents, which act to establish avoidance behaviours in animals, have the... Read More about Using drones and sirens to elicit avoidance behaviour in white rhinoceros as an anti-poaching tactic..

Catch me if you can: the influence of refuge / trap design, previous feeding experience, and semiochemical lures on vine weevil (Coleoptera: Curculionidae) monitoring success. (2019)
Journal Article
(2019). Catch me if you can: the influence of refuge / trap design, previous feeding experience, and semiochemical lures on vine weevil (Coleoptera: Curculionidae) monitoring success. Pest Management Science, https://doi.org/10.1002/ps.5545

BACKGROUND: Vine weevil, Otiorhynchus sulcatus F. (Coleoptera: Curculionidae), is one of the most economically important pest species of berry and ornamental crops globally. Monitoring this nocturnal pest can be difficult and time consuming and the... Read More about Catch me if you can: the influence of refuge / trap design, previous feeding experience, and semiochemical lures on vine weevil (Coleoptera: Curculionidae) monitoring success..

An insight into advances in fisheries biology, genetics and genomics of African tilapia species of interest in aquaculture (2019)
Journal Article
(2019). An insight into advances in fisheries biology, genetics and genomics of African tilapia species of interest in aquaculture. https://doi.org/10.1016/j.aqrep.2019.100188

Morphological identification of tilapia species is complicated by extensive intraspecific variation of morphological characters used for classical identification. To address this obstacle, use of molecular techniques as additional tools for identific... Read More about An insight into advances in fisheries biology, genetics and genomics of African tilapia species of interest in aquaculture.

Associative learning and memory retention of nectar yeast volatiles in a generalist parasitoid (2019)
Journal Article
(2019). Associative learning and memory retention of nectar yeast volatiles in a generalist parasitoid. Animal Behaviour, 137 - 146. https://doi.org/10.1016/j.anbehav.2019.05.006

Understanding how animals learn is crucial to interpreting animal behaviour. Flower-visiting insects, such as bees and parasitoids, are excellent animal models to study visual and olfactory learning, including memory phenomena. The diversity of resou... Read More about Associative learning and memory retention of nectar yeast volatiles in a generalist parasitoid.

Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma (2019)
Journal Article
Tonge. (2019). Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma. Scientific reports, 9, Article 8912. https://doi.org/10.1038/s41598-019-45257-1

Asthma is a chronic inflammatory disorder of the airways. Disease presentation varies greatly in terms of cause, development, severity, and response to medication, and thus the condition has been subdivided into a number of asthma phenotypes. There i... Read More about Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma.

Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells (2019)
Journal Article
Trent, S., Hall, J., Connelly, W. M., & Errington, A. C. (2019). Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells. eNeuro, 6(3), ENEURO.0364 - 18.2019. https://doi.org/10.1523/ENEURO.0364-18.2019

Copy number variation (CNV) at chromosomal region 15q11.2 is linked to increased risk of neurodevelopmental disorders including autism and schizophrenia. A significant gene at this locus is cytoplasmic fragile X mental retardation protein (FMRP) inte... Read More about Cyfip1 Haploinsufficiency Does Not Alter GABAA Receptor d-Subunit Expression and Tonic Inhibition in Dentate Gyrus PV+ Interneurons and Granule Cells.

Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford. (2019)
Journal Article
(2019). Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford. International Journal of Environmental Research and Public Health, https://doi.org/10.3390/ijerph16122129

(1) Introduction: Human exposure to aluminium is a burgeoning problem. In 1988, the population of the Cornish town of Camelford was exposed to exceedingly high levels of aluminium in their potable water supply. Herein we provide evidence that alumi... Read More about Aluminium in Brain Tissue in Epilepsy: A Case Report from Camelford..

Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity (2019)
Journal Article
Clifton, N. E., Trent, S., Thomas, K. L., & Hall, J. (2019). Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity. Molecular Neuropsychiatry, 5(3), 147 - 161. https://doi.org/10.1159/000500267

Alterations in synaptic signaling and plasticity occur during the refinement of neural circuits over the course of development and the adult processes of learning and memory. Synaptic plasticity requires the rearrangement of protein complexes in the... Read More about Regulation and Function of Activity-Dependent Homer in Synaptic Plasticity.

Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers. (2019)
Journal Article
(2019). Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers. Contemporary Clinical Trials Communications, 100361 - ?. https://doi.org/10.1016/j.conctc.2019.100361

We previously reported the safety and efficacy of low dose BaP [Bezafibrate (Bez) and Medroxyprogesterone acetate (MPA)] in 20 acute myeloid leukaemia (AML) patients for whom chemotherapy was not an option. This study provided evidence that BaP had a... Read More about Single arm phase II trial assessing the safety, compliance with and activity of Bezafibrate and medroxyProgesterone acetate (BaP) therapy against myeloid and lymphoid cancers..

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. (2019)
Journal Article
Mycroft-West, C., Cooper, L., Devlin, A., Procter, P., Guimond, S., Guerrini, M., …Skidmore, M. (2019). A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease. Marine Drugs, 17, 293 -293. https://doi.org/10.3390/md17050293

Therapeutic options for Alzheimer's disease, the most common form of dementia, are currently restricted to palliative treatments. The glycosaminoglycan heparin, widely used as a clinical anticoagulant, has previously been shown to inhibit the Alzheim... Read More about A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease..

Effect of water source and feed regime on development and phenotypic quality in Anopheles gambiae (s.l.): prospects for improved mass-rearing techniques towards release programmes. (2019)
Journal Article
(2019). Effect of water source and feed regime on development and phenotypic quality in Anopheles gambiae (s.l.): prospects for improved mass-rearing techniques towards release programmes. Parasites and Vectors, https://doi.org/10.1186/s13071-019-3465-0

BACKGROUND: In many malaria-endemic sub-Saharan countries, insecticide resistance poses a threat to existing mosquito control measures, underscoring the need for complementary control methods such as sterile and/or genetically-modified mosquito rel... Read More about Effect of water source and feed regime on development and phenotypic quality in Anopheles gambiae (s.l.): prospects for improved mass-rearing techniques towards release programmes..

Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers. (2019)
Journal Article
Adams, C., Mather, M., Radu, V., Simpson, D., Barcons, A., Price, J., & Levett, S. (2019). Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers. Small, 15(22), e1900455. https://doi.org/10.1002/smll.201900455

Fluorescent nanodiamonds (fNDs) containing nitrogen vacancy (NV) centers are promising candidates for quantum sensing in biological environments. This work describes the fabrication and implementation of electrospun poly lactic-co-glycolic acid (PLGA... Read More about Quantum Sensing in a Physiological-Like Cell Niche Using Fluorescent Nanodiamonds Embedded in Electrospun Polymer Nanofibers..

Protein Short-Time Diffusion in a Naturally Crowded Environment. (2019)
Journal Article
(2019). Protein Short-Time Diffusion in a Naturally Crowded Environment. The journal of physical chemistry letters, 1709 - 1715. https://doi.org/10.1021/acs.jpclett.9b00345

The interior of living cells is a dense and polydisperse suspension of macromolecules. Such a complex system challenges an understanding in terms of colloidal suspensions. As a fundamental test we employ neutron spectroscopy to measure the diffusion... Read More about Protein Short-Time Diffusion in a Naturally Crowded Environment..