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Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region (2015)
Journal Article
Russo. (2015). Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region. PloS one, e0142509 - e0142509. https://doi.org/10.1371/journal.pone.0142509

Malaria is an infectious disease caused by Plasmodium parasites. It results in an annual death-toll of ~ 600,000. Resistance to all medications currently in use exists, and novel antimalarial drugs are urgently needed. Plasmepsin V (PmV) is an essent... Read More about Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region.

Disclosing the results of the invasive cervical cancer review to patients: a survey of lead colposcopists across England (2015)
Journal Article
Sherman, S., Nailer, E., Pearmain, P., Todd, R., & Redman, C. (2015). Disclosing the results of the invasive cervical cancer review to patients: a survey of lead colposcopists across England. Cytopathology, 237-241. https://doi.org/10.1111/cyt.12283

Objective: To survey lead colposcopists to explore the extent to which patients are currently being invited to discuss the results of their invasive cervical cancer review, the reasons why this might not be happening and the clinician experience. Met... Read More about Disclosing the results of the invasive cervical cancer review to patients: a survey of lead colposcopists across England.

Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa? (2015)
Journal Article
(2015). Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?. Parasites and Vectors, https://doi.org/10.1186/s13071-015-1190-x

Background
Anopheles gambiae s.s. and An. coluzzii are two of the most important malaria vector species in sub-Saharan Africa. These recently-diverged sibling species do not exhibit intrinsic post-zygotic barriers to reproduction and are thought to... Read More about Does extreme asymmetric dominance promote hybridization between Anopheles coluzzii and Anopheles gambiae s.s. in seasonal malaria mosquito communities of West Africa?.

Odorant receptor-based discovery of natural repellents of human lice (2015)
Journal Article
(2015). Odorant receptor-based discovery of natural repellents of human lice. Journal of Chemical Ecology, 103 - 109. https://doi.org/10.1016/j.ibmb.2015.10.009

The body louse, Pediculus humanus humanus, is an obligate blood-feeding ectoparasite and an important insect vector that mediates the transmission of diseases to humans. The analysis of the body louse genome revealed a drastic reduction of the chemos... Read More about Odorant receptor-based discovery of natural repellents of human lice.

The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products (2015)
Journal Article
Rafiq, Q. A., Ortega, I., Jenkins, S. I., Wilson, S. L., Patel, A. K., Barnes, A. L., …Smith, D. (2015). The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products. Regenerative Medicine, 989 -1003. https://doi.org/10.2217/rme.15.56

Although the importance of translation for the development of tissue engineering, regenerative medicine and cell-based therapies is widely recognized, the process of translation is less well understood. This is particularly the case among some early... Read More about The early career researcher's toolkit: translating tissue engineering, regenerative medicine and cell therapy products.

The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes (2015)
Journal Article
Masood. (2015). The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes. BMC Infectious Diseases, https://doi.org/10.1186/s12879-015-1210-7

Background
The most common cause of Gram-negative bacterial neonatal meningitis is E. coli K1. It has a mortality rate of 10–15 %, and neurological sequelae in 30–50 % of cases. Infections can be attributable to nosocomial sources, however the pre-c... Read More about The molecular characterisation of Escherichia coli K1 isolated from neonatal nasogastric feeding tubes.

Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. (2015)
Journal Article
Forrester-Soto. (2015). Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Frontiers in Microbiology, 1037 - 1037. https://doi.org/10.3389/fmicb.2015.01037

Previous imported cases of Lassa fever (LF) into the United Kingdom from the Ivory Coast and Mali, as well as the detection of Lassa virus (LASV) among the Mastomys natalensis population within Mali has led to the suggestion that the endemic area for... Read More about Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage..

Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans (2015)
Journal Article
Moura, G., Lucena, S., Andrade De Lima, M., Nascimento, F., Gesteira, T., Nader, H., …Tersariol, I. (2015). Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans. Cell Death Discovery, 1, 15005--15005. https://doi.org/10.1038/cddiscovery.2015.5

Here, we present evidence for the positive allosteric modulation of the P2X7 receptor through glycosaminoglycans (GAGs) in CHO (cell line derived from the ovary of the Chinese hamster) cells. The marked potentiation of P2X7 activity through GAGs in t... Read More about Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans.

Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit (2015)
Journal Article
Masood. (2015). Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit. BMC Genomics, https://doi.org/10.1186/s12864-015-1961-y

Background: Cronobacter sakazakii is a member of the genus Cronobacter that has frequently been isolated from powdered infant formula (PIF) and linked with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis. The Cron... Read More about Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke (2015)
Journal Article
Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., …Maysami, S. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. https://doi.org/10.1177/0271678X15606714

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in... Read More about A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Non-random patterns in viral diversity (2015)
Journal Article
Anthony, S., Islam, A., Johnson, C., Navarrete-Macias, I., Liang, E., Jain, K., …Lipkin, W. (2015). Non-random patterns in viral diversity. Nature communications, https://doi.org/10.1038/ncomms9147

It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled thro... Read More about Non-random patterns in viral diversity.

The flip side of the other-race coin: They all look different to me (2015)
Journal Article
(2015). The flip side of the other-race coin: They all look different to me. British Journal of Psychology, 374-388. https://doi.org/10.1111/bjop.12147

Poorer recognition of other-race faces than own-races faces has been attributed to a problem of discrimination (i.e., telling faces apart). The conclusion that ‘they all look the same to me' is based on studies measuring the perception/memory of high... Read More about The flip side of the other-race coin: They all look different to me.

Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England (2015)
Journal Article
Wastling. (2015). Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England. Parasites and Vectors, https://doi.org/10.1186/s13071-015-1059-z

Background
The protozoan Giardia duodenalis is a common but highly diverse human parasite that comprises a complex of seven morphologically identical genetic assemblages, further divided into sub-assemblages. There is very little information availab... Read More about Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England.

Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context (2015)
Journal Article
Feber, R. E., Johnson, P. J., Bell, J. R., Chamberlain, D. E., Firbank, L. G., Fuller, R. J., …Macdonald, D. W. (2015). Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context. PloS one, 10(8), Article e0135921. https://doi.org/10.1371/journal.pone.0135921

Organic farming, a low intensity system, may offer benefits for a range of taxa, but what affects the extent of those benefits is imperfectly understood. We explored the effects of organic farming and landscape on the activity density and species den... Read More about Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context.

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. (2015)
Journal Article
(2015). Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. PLoS Neglected Tropical Diseases, e0003975 - ?. https://doi.org/10.1371/journal.pntd.0003975

The parasitic flagellate Trypanosoma vivax is a cause of animal trypanosomiasis across Africa and South America. The parasite has a digenetic life cycle, passing between mammalian hosts and insect vectors, and a series of developmental forms adapted... Read More about Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax..

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. (2015)
Journal Article
Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., McColl, B., & Lawrence, C. (2015). Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. Journal of Neuroinflammation, 140 - ?. https://doi.org/10.1186/s12974-015-0359-8

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesit... Read More about Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke..

Rescue of long-term memory after reconsolidation blockade (2015)
Journal Article
Trent, S., Barnes, P., Hall, J., & Thomas, K. L. (2015). Rescue of long-term memory after reconsolidation blockade. Nature communications, 4, Article 7897. https://doi.org/10.1038/ncomms8897

Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdow... Read More about Rescue of long-term memory after reconsolidation blockade.

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. (2015)
Journal Article
Winter. (2015). Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chemical Science, 6147 - 6157. https://doi.org/10.1039/C5SC02155C

The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential for embryogenesis and for tissue/organ regeneration in post-natal life. HGF/SF-MET signall... Read More about Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding..