All Outputs (8)

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells (2022)
Thesis
Kavousi, N. (2022). An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells. (Thesis). Keele University

The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3, PP4R4). Previous studies have shown that PP4c acts as a tumour suppressor an... Read More about An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells.

Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. (2022). Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

Heparin: an established anticoagulant drug with therapeutic potential for COVID-19 (2022)
Thesis
McIntosh, O. G. (2022). Heparin: an established anticoagulant drug with therapeutic potential for COVID-19. (Thesis). Keele University

The biologically and medically important heparan sulphate and heparin polysaccharides have been previously shown to mediate viral cell entry for enveloped viruses. Furthermore, heparin and its analogues have been shown to have anti-inflammatory and a... Read More about Heparin: an established anticoagulant drug with therapeutic potential for COVID-19.

The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies (2022)
Thesis
Ali, J. (2022). The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies. (Thesis). Keele University

The peach potato aphid, Myzus persicae, is a serious crop pest with a worldwide distribution. It has short generation time, high reproductive rate and the ability to adapt to new hosts and develop resistance against major class of insecticides. There... Read More about The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies.

Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease (2022)
Thesis
Mycroft-West, C. J. (2022). Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease. (Thesis). Keele University

Currently, only palliative drugs are available for the treatment of Alzheimer’s disease, therefore there is an urgent need to develop therapeutics targeting the underlying aetiology of the disease. The clinical anticoagulant heparin has previously be... Read More about Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease.

An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria (2022)
Thesis
Ogbolosingha, A. J. (2022). An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria. (Thesis). Keele University

Cerebral malaria (CM) is the most life-threatening complication of Plasmodium falciparum (Pf) infection. A key hallmark of CM is the sequestration of Pf infected red blood cells (PRBC) to the human brain endothelial cells (HBEC) of the blood brain ba... Read More about An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria.

An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease (2022)
Thesis
Earle, H. (2022). An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease. (Thesis). Keele University

Ferroptosis is a non-apoptotic, iron-dependent cell death pathway first identified in an engineered tumorigenic cell line in 2012. Hallmark characteristics include direct or indirect loss of functional GPX4 enzymes, resulting in depletion of glutathi... Read More about An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease.

Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes (2022)
Thesis
Highton, G. A. (2022). Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes. (Thesis). Keele University

Between 2000 and 2015, Sub-Saharan Africa made historic process against the scourge of malaria. Since this time there has been a plateau in the number of malaria cases and mortalities. The decreasing efficacy of the current methods used against this... Read More about Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes.