All Outputs (154)

Investigating multiple factors affecting the successful infection and transmission of arboviruses (2024)
Thesis
Widlake, E. (2024). Investigating multiple factors affecting the successful infection and transmission of arboviruses. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/850302

Arboviruses are arthropod-borne viruses that cycle between a vertebrate host and an arthropod vector. This disparate life cycle involves adapting to two alternate animals and the differing tissues and systems within them. A range of factors influence... Read More about Investigating multiple factors affecting the successful infection and transmission of arboviruses.

Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems (2024)
Thesis
Nascimento, C. L. D. (2024). Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853170

Vector-borne diseases are responsible for 17% of all infectious diseases worldwide and contribute to more than 700 000 deaths annually, mainly in sub-Saharan countries. Vector surveillance is a crucial element of vector control programmes to assure t... Read More about Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems.

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum (2024)
Thesis
Mobley, R. M. (2024). Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853179

Malaria continues to cause great global health concerns despite efforts for control and elimination. The emergence of resistance to components of the frontline artemisinin combination therapy highlights the urgent need for novel malaria therapeutics... Read More about Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum.

Screening of an open-source compound library against the livestock parasite Trypanosoma evansi (2024)
Thesis
Ansah, M. L. K. (2024). Screening of an open-source compound library against the livestock parasite Trypanosoma evansi. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853242

Surra is a neglected tropical veterinary disease that causes a large socioeconomic burden in sub-Saharan Africa, South America, the middle east, Asia, and parts of Southern Europe. Although symptoms can be mild in wild animal species, disease in dome... Read More about Screening of an open-source compound library against the livestock parasite Trypanosoma evansi.

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis
Tierney, L. J. (2024). Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775433

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.

Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment (2023)
Thesis
Ottih, E. C. (2023). Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment. (Thesis). Keele University

Genetic Mosquito mass release is a promising tool in the suppression of wild Anopheles gambiae sensu lato mosquitoes as part of malaria control in Africa. This tool requires a plethora number of eggs and a strain with good fitness. Thus, the success... Read More about Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment.

In-solution and interface study on biological model membranes and their interaction with Prohibitin (2023)
Thesis
Piccinini, A. (2023). In-solution and interface study on biological model membranes and their interaction with Prohibitin. (Thesis). Keele University

Prohibitins (PHB) play a crucial role in premature cellular ageing, tumour suppression, cell cycle regulation, and apoptosis, and their deregulation is involved in viral infections, neurological and cardiovascular diseases and cancer. Despite the ess... Read More about In-solution and interface study on biological model membranes and their interaction with Prohibitin.

Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay (2023)
Thesis
Freakley, A. L. (2023). Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay. (Thesis). Keele University

Leishmaniasis is a neglected tropical disease associated with poverty, deprived socio-economic settings and population displacement, primarily due to conflict. The causative agent are species of Leishmania parasites that are transmitted by sand flies... Read More about Study to determine the rate of kill of anti-leishmanial drugs using a novel bioluminescence-based assay.

ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control (2023)
Thesis
Devlin, A. J. (2023). ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control. (Thesis). Keele University

Heparin is a member of the glycosaminoglycan (GAG) family of naturally occurring, polydisperse, linear polysaccharides. Heparin is a ubiquitous anticoagulant drug, a member of the WHO’s list of vital medicines and the second used drug by weight after... Read More about ATR-FTIR spectroscopy of heparin: using multivariate analyses for next-generation quality control.

An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells (2022)
Thesis
Kavousi, N. (2022). An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells. (Thesis). Keele University

The serine/threonine protein phosphatase 4 holoenzyme consists of PP4 catalytic subunit (PP4c), which interacts with four different regulatory subunits (PP4R1, PP4R2, PP4R3, PP4R4). Previous studies have shown that PP4c acts as a tumour suppressor an... Read More about An investigation into the functional roles of protein phosphatase 4 regulatory subunits PP4R3A and PP4R3B in leukemic T-cells.

Investigating the interaction between dengue viral envelope proteins and host receptor molecules (2022)
Thesis
Hyatt, J. G. (2022). Investigating the interaction between dengue viral envelope proteins and host receptor molecules. (Thesis). Keele University

Infection of dengue remains to this date a major socio-economic and public health challenge for large parts of the world, especially low- and middle- income countries in the tropics and sub-tropics. Despite the prevalence of the associated neglected... Read More about Investigating the interaction between dengue viral envelope proteins and host receptor molecules.

The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies (2022)
Thesis
Ali, J. (2022). The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies. (Thesis). Keele University

The peach potato aphid, Myzus persicae, is a serious crop pest with a worldwide distribution. It has short generation time, high reproductive rate and the ability to adapt to new hosts and develop resistance against major class of insecticides. There... Read More about The chemical ecology of a model aphid pest, Myzus persicae, and its natural enemies.

Heparin: an established anticoagulant drug with therapeutic potential for COVID-19 (2022)
Thesis
McIntosh, O. G. (2022). Heparin: an established anticoagulant drug with therapeutic potential for COVID-19. (Thesis). Keele University

The biologically and medically important heparan sulphate and heparin polysaccharides have been previously shown to mediate viral cell entry for enveloped viruses. Furthermore, heparin and its analogues have been shown to have anti-inflammatory and a... Read More about Heparin: an established anticoagulant drug with therapeutic potential for COVID-19.

Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease (2022)
Thesis
Mycroft-West, C. J. (2022). Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease. (Thesis). Keele University

Currently, only palliative drugs are available for the treatment of Alzheimer’s disease, therefore there is an urgent need to develop therapeutics targeting the underlying aetiology of the disease. The clinical anticoagulant heparin has previously be... Read More about Non-anticoagulant glycosaminoglycan extracts isolated from aquatic species inhibit BACE-1: a key drug target in Alzheimer’s Disease.

An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria (2022)
Thesis
Ogbolosingha, A. J. (2022). An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria. (Thesis). Keele University

Cerebral malaria (CM) is the most life-threatening complication of Plasmodium falciparum (Pf) infection. A key hallmark of CM is the sequestration of Pf infected red blood cells (PRBC) to the human brain endothelial cells (HBEC) of the blood brain ba... Read More about An in vitro study of the modulation of astrocytes in the blood brain barrier during human cerebral malaria.

Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes (2022)
Thesis
Highton, G. A. (2022). Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes. (Thesis). Keele University

Between 2000 and 2015, Sub-Saharan Africa made historic process against the scourge of malaria. Since this time there has been a plateau in the number of malaria cases and mortalities. The decreasing efficacy of the current methods used against this... Read More about Exploring the use of attractive sugar bait stations to deliver antiplasmodial compounds to Anopheles mosquitoes.

An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease (2022)
Thesis
Earle, H. (2022). An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease. (Thesis). Keele University

Ferroptosis is a non-apoptotic, iron-dependent cell death pathway first identified in an engineered tumorigenic cell line in 2012. Hallmark characteristics include direct or indirect loss of functional GPX4 enzymes, resulting in depletion of glutathi... Read More about An in vitro study into the effects of erastin in the SH-SY5Y cell line, as a model of Parkinson’s disease.

Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies (2021)
Thesis
Mogas Barcons, A. (2021). Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies. (Thesis). Keele University

Spinal cord injury is a devastating condition affecting thousands of people every year. The spinal cord does not have the intrinsic capacity for regeneration due to a complex cascade of physical and chemical barriers that prevent axonal growth and le... Read More about Development of a chick embryo spinal cord injury model as a platform to test neural tissue engineering strategies.

The potential of bird feeders to be used for ecological monitoring of vectors for Phytophthora ramorum in garden and woodland environments (2021)
Thesis
Tosdevin, M. W. (2021). The potential of bird feeders to be used for ecological monitoring of vectors for Phytophthora ramorum in garden and woodland environments. (Thesis). Keele University

Bird feeders were investigated for their use in determining whether birds are vectoring the tree disease Phytophthora ramorum, and whether feeders are acting as nodes of spore transfer. This was done by studying feeders at residences in Keele Univers... Read More about The potential of bird feeders to be used for ecological monitoring of vectors for Phytophthora ramorum in garden and woodland environments.

Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex (2021)
Thesis
Pettitt, G. (2021). Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex. (Thesis). Keele University

Despite receiving the second largest dopaminergic projection from the ventral tegmental area (VTA) and having a pivotal role in conveying non-spatial information received from sensory cortices, the physiological functions of the lateral entorhinal co... Read More about Pharmacological analysis of dopaminergic synaptic plasticity in rodent lateral entorhinal cortex.