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All Outputs (154)

Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex (2021)
Thesis
Wells, T. R. (2021). Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex. (Thesis). Keele University

The entorhinal cortex serves as the interface region between allocortical input and the hippocampus, with current theories suggesting that the region is involved in memory encoding, with dopamine serving as a “motivational currency” provided to memor... Read More about Dopaminergic modulation of activity dependent synaptic plasticity in rodent lateral entorhinal cortex.

Structural characterisation of the human innate immune proteins FIBCD1 and surfactant proteins A and D (2021)
Thesis
Williams, H. M. (2021). Structural characterisation of the human innate immune proteins FIBCD1 and surfactant proteins A and D. (Thesis). Keele University

The surfactant proteins A and D (SP-A and SP-D) and fibrinogen C containing domain 1 (FIBCD1) are pattern recognition receptors, which recognise pathogens through the binding of carbohydrate residues embedded within surface structures. The work prese... Read More about Structural characterisation of the human innate immune proteins FIBCD1 and surfactant proteins A and D.

Investigation into the role of long non-coding RNAs in neuroblastoma and glioma (2021)
Thesis
Bountali, A. (2021). Investigation into the role of long non-coding RNAs in neuroblastoma and glioma. (Thesis). Keele University

Long non-coding RNAs (lncRNAs) play key roles in several processes in healthy and cancer settings and the underpinning mechanisms of their action are thoroughly investigated. In line with this, this study investigates the role of the lncRNA myocardia... Read More about Investigation into the role of long non-coding RNAs in neuroblastoma and glioma.

The role of the microbiome in rheumatoid arthritis (2020)
Thesis
Hammad, D. B. M. (2020). The role of the microbiome in rheumatoid arthritis. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/418967

The human microbiome plays a vital role in both health and disease. The evolution of molecular techniques to characterise entire microbiome communities has renewed interest in the involvement of microorganisms in the pathogenesis of Rheumatoid arthri... Read More about The role of the microbiome in rheumatoid arthritis.

Larval ecological adaptations, water quality and aquaticbacterial communities in Anopheles gambiae s.l. :prospects for improved rearing techniques towards releaseprogrammes (2020)
Thesis
Akpodiete, N. O. (2020). Larval ecological adaptations, water quality and aquaticbacterial communities in Anopheles gambiae s.l. :prospects for improved rearing techniques towards releaseprogrammes. (Thesis). Keele University

The sibling species Anopheles gambiae s.s. and Anopheles coluzzii are the most important vectors of human malaria in sub-Saharan Africa. They are thought to be undergoing speciation with gene flow with rare viable hybrids but are reproductively isola... Read More about Larval ecological adaptations, water quality and aquaticbacterial communities in Anopheles gambiae s.l. :prospects for improved rearing techniques towards releaseprogrammes.

Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin (2020)
Thesis
Earps, H. F. (2020). Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin. (Thesis). Keele University

Human immunoglobulin (Ig) G is the most commonly found class of antibody in the human body and is involved in pathogen recognition as a part of the adaptive and innate immune response. Recognition occurs through the fragment antibody binding (FAB) re... Read More about Structural characterisation of human immunoglobulin G Fc fragment and its interaction with heparin.

The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum (2020)
Thesis
Anagu, L. O. (2020). The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum. (Thesis). Keele University

Plasmodium falciparum encodes a family of key virulence genes called var genes. These encode adhesive proteins that are expressed on infected erythrocytes in a mutually exclusive manner. The parasite’s sirtuins have been implicated in epigenetic sele... Read More about The impact of host stress on virulence phenotypes in the malaria parasite Plasmodium falciparum.

ARF regulating proteins as novel drug targets in Trypanosoma brucei (2020)
Thesis
Chandrathas, J. P. (2020). ARF regulating proteins as novel drug targets in Trypanosoma brucei. (Thesis). Keele University

Human African Trypanosomiasis (HAT) and Animal African Trypanosomiasis (AAT) are neglected tropical diseases that pose a huge socioeconomic and health burden in poorer countries in sub-Saharan Africa. The causative agents of these diseases are the Tr... Read More about ARF regulating proteins as novel drug targets in Trypanosoma brucei.

The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2 (2020)
Thesis
Benn, E. E. (2020). The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2. (Thesis). Keele University

The negative ways in which diabetes affects the brain, and the role of neural insulin and glucose is an interesting research topic as research has shown a correlation between neurodegenerative diseases and diabetes. This thesis focuses on how polyuns... Read More about The neuroprotective role of polyunsaturated fatty acids in a palmitic acid model of diabetes mellitus type 2.

Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells (2020)
Thesis
Grimes, D. (2020). Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells. (Thesis). Keele University

Pro-inflammatory cytokines and glucolipotoxicity are known mediators of beta cell death and dysfunction in the pathogenesis of type 1 and type 2 diabetes mellitus (DM). In contrast to the pro-apoptotic effects of long-chain saturated fatty acids in b... Read More about Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells.

Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes (2020)
Thesis
Osborn, A. H. (2020). Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes. (Thesis). Keele University

Fibrocyte degeneration in the cochlear lateral wall is one possible pathology of age-related metabolic hearing loss (presbyacusis). Fibrocytes play a role in potassium recycling and maintenance of the endocochlear potential (EP). It has been proposed... Read More about Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes.

The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells (2020)
Thesis
Mohammed, S. N. (2020). The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells. (Thesis). Keele University

Background and aims: Aggressiveness and invasiveness of breast cancer are influenced by multiple cellular and molecular factors, some of which are yet to be elucidated. In normal cells, vacuolar H (+) -ATPase (V ATPases), which pump protons across th... Read More about The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells.

Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model (2020)
Thesis
Whittle, E. L. (2020). Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model. (Thesis). Keele University

Asthma is one of the most common chronic diseases of the 21st century, affecting over 300 million people worldwide 1. It is an inflammatory disorder of the airways that is a major public concern globally due to increasing prevalence and rates of mort... Read More about Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model.

The structure of Lipid A and composition of the oligosaccharides of the lipopolysaccharides of the bacterial species: Veillonella parvula (2019)
Thesis
Pither, M. (2019). The structure of Lipid A and composition of the oligosaccharides of the lipopolysaccharides of the bacterial species: Veillonella parvula. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/417815

Veillonella parvula is a Gram-negative bacterium known to be an abundant commensal coloniser of the human gut and mouth; it is linked to progression of childhood immune system but has also been found to be an opportunistic pathogen. Lipopolysaccharid... Read More about The structure of Lipid A and composition of the oligosaccharides of the lipopolysaccharides of the bacterial species: Veillonella parvula.

Investigation of modified forms of serum C-reactive protein in diabetes mellitus (2019)
Thesis
Mahmood, S. M. (2019). Investigation of modified forms of serum C-reactive protein in diabetes mellitus. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414936

C-reactive protein (CRP) is known to dissociate to its monomeric subunits (mCRP) in vivo. Furthermore, hyperglycaemia associated with diabetes mellitus (DM) results in glycation of serum proteins to a various extent based on their half-life and glyca... Read More about Investigation of modified forms of serum C-reactive protein in diabetes mellitus.

Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models (2019)
Thesis
Andoh, N. E. (2019). Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413819

During cerebral malaria (CM), sequestration of Plasmodium falciparum infected red blood cells (PRBC) to the blood-brain barrier (BBB) is associated with BBB disruption and long-term neurological sequelae in CM survivors, possibly linked to the activa... Read More about Changes in human endothelial cells and astrocytes of the blood-brain barrier (BBB) in cerebral malaria: using in vitro BBB models.

Genetic and ecological processes of speciation in the Anopheles coluzzii and Anopheles gambiae sibling species (2019)
Thesis
Dawam, N. N. (2019). Genetic and ecological processes of speciation in the Anopheles coluzzii and Anopheles gambiae sibling species. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/414328

Malaria is a leading cause of death, killing thousands every year. Sub-Saharan Africa has the highest mortality rate, with pregnant women and children under the age of five most affected. The culprits responsible for transmission of the disease are m... Read More about Genetic and ecological processes of speciation in the Anopheles coluzzii and Anopheles gambiae sibling species.

Through fog: An autoethnography of childhood emotional neglect. (2019)
Thesis
Blanchard, A. (2019). Through fog: An autoethnography of childhood emotional neglect. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413773

Childhood emotional neglect is increasingly recognised as significant and widespread, potentially linked to adult depression and anxiety, yet it remains hidden, poorly understood, ill-defined, foggy. Less widely researched than other forms of child m... Read More about Through fog: An autoethnography of childhood emotional neglect..

Biochemical, biophysical, and structural studies of seed proteins from Moringa oleifera and implications for traditional water purification (2019)
Thesis
Moulin, M. (2019). Biochemical, biophysical, and structural studies of seed proteins from Moringa oleifera and implications for traditional water purification. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/413067

Moringa oleifera is a tropical plant that belongs to the Moringaceae family and is native to northern India. Moringa oleifera is called The Miracle Tree because many of its parts have valuable applications. In particular, seed extracts from the plant... Read More about Biochemical, biophysical, and structural studies of seed proteins from Moringa oleifera and implications for traditional water purification.