All Outputs (154)

Small angle scattering studies of chromatin proteins in the human malarial parasite
Thesis
Jordan, A. (2017). Small angle scattering studies of chromatin proteins in the human malarial parasite

This thesis describes the biochemical, biophysical and structural characterisation of two proteins believed to play an important role in active gene silencing mechanisms present in the human malarial parasite, Plasmodium falciparum. These investiga... Read More about Small angle scattering studies of chromatin proteins in the human malarial parasite.

Activation of endothelial cells and its potential involvement in blood-brain barrier damage in cerebral malaria: an in vitro study
Thesis
Mohd Nasir, M. H. (2015). Activation of endothelial cells and its potential involvement in blood-brain barrier damage in cerebral malaria: an in vitro study

One of the severe complications of a Plasmodium falciparum infection is cerebral malaria (CM). CM is characterised by the accumulation of mature infected red blood cells (RBC) in the brain microvasculature. One of the consistent detrimental effects o... Read More about Activation of endothelial cells and its potential involvement in blood-brain barrier damage in cerebral malaria: an in vitro study.

Structural studies of the recognition of bacterial lipopolysaccharides by human surfactant protein-D
Thesis
Smallcombe, C. (2016). Structural studies of the recognition of bacterial lipopolysaccharides by human surfactant protein-D

SP-D is a large hydrophilic protein, consisting of four collagenous trimers, which is secreted by alveolar type II and non-ciliated bronchiolar epithelial cells and participates in calcium-dependant agglutination of inhaled microorganisms. Known high... Read More about Structural studies of the recognition of bacterial lipopolysaccharides by human surfactant protein-D.

Genetic and behavioural mechanisms of reproductive isolation and speciation in recently-diverged sibling species of the malaria vector Anopheles gambiae s.l.
Thesis
(2016). Genetic and behavioural mechanisms of reproductive isolation and speciation in recently-diverged sibling species of the malaria vector Anopheles gambiae s.l

Anopheles gambiae s.l. species are reported as the most important vectors due to their ability to spread and exploit both temporary and man-made breeding sites. These factors combined with their capacity to transmit malaria, make them wide-open subje... Read More about Genetic and behavioural mechanisms of reproductive isolation and speciation in recently-diverged sibling species of the malaria vector Anopheles gambiae s.l..

The influence of beta-glucans on the relationship between carp (Cyprinus carpio) and its associated microbiome
Thesis
carp (Cyprinus carpio) and its associated microbiome

Fish are in contact with microbiota from the moment of hatching. Exterior organs, i.e. skin, gills and intestinal system, are colonised by commensal bacteria populations and a symbiotic relationship is formed. The fish provides a niche and nutrients... Read More about The influence of beta-glucans on the relationship between carp (Cyprinus carpio) and its associated microbiome.

The genetics and ecology of male reproductive investments in the malaria mosquito Anopheles gambiae s.s
Thesis
(2015). The genetics and ecology of male reproductive investments in the malaria mosquito Anopheles gambiae s.s

Malaria continues to be a major global health problem due to high mortality and morbidity rate in endemic regions. An. gambiae s.s is the major vector in endemic African countries. About 198 million cases of malaria were recorded globally in 2013 and... Read More about The genetics and ecology of male reproductive investments in the malaria mosquito Anopheles gambiae s.s.

The use of carbohydrates as an immunomodulator in carp (Cyprinus carpio)
Thesis
(2017). The use of carbohydrates as an immunomodulator in carp (Cyprinus carpio)

Fish diseases are the most important challenge that is facing the development of the aquaculture industry. Recently, there has been substantial interest to control fish diseases through the use of immunomodulators, such as ß-glucans that activate a r... Read More about The use of carbohydrates as an immunomodulator in carp (Cyprinus carpio).

Structural studies of a2-macroglobulin from the horseshoe crab Limulus polyphemus
Thesis
Nicosia, M. (2016). Structural studies of a2-macroglobulin from the horseshoe crab Limulus polyphemus

This work is focused on structural studies of the innate immune protein a2-macroglobulin from the horseshoe crab, Limulus Polyphemus, using crystallography and structure prediction software to reveal clues about the structure and function of this key... Read More about Structural studies of a2-macroglobulin from the horseshoe crab Limulus polyphemus.

Assessment of magnetic particles for neural stem cell-based therapies
Thesis
Adams, C. F. (2015). Assessment of magnetic particles for neural stem cell-based therapies

Transplantation of genetically engineered neural stem cells (NSCs) into sites of central nervous system (CNS) disease/injury is a promising strategy to promote repair of damaged tissue. However, translating this strategy into the clinic requires seve... Read More about Assessment of magnetic particles for neural stem cell-based therapies.

Biosilicification in Oryza sativa and other plants
Thesis
Stokes, I. (2016). Biosilicification in Oryza sativa and other plants

Rice (Oryza sativa) is well known as a biosilicifier though the mechanisms which underlie the silica deposition in them are still relatively unknown. Silica deposits in rice were imaged through various complementary techniques including PDMPO stainin... Read More about Biosilicification in Oryza sativa and other plants.

Semiochemical mediated oviposition and mating in Phlebotomus argentipes (Diptera: Psychodidae) sand flies
Thesis
Yaman, K. (2016). Semiochemical mediated oviposition and mating in Phlebotomus argentipes (Diptera: Psychodidae) sand flies

Phlebotomus argentipes (Diptera: Psychodidae) is an important vector responsible for the transmission of Leishmania donovani that causes visceral leishmaniasis (VL) or kala-azar, in the sub-continent of India. The aims of this study were to investiga... Read More about Semiochemical mediated oviposition and mating in Phlebotomus argentipes (Diptera: Psychodidae) sand flies.

A spatial and temporal analysis of Plasmodium falciparum transcription
Thesis
Russell, K. (2014). A spatial and temporal analysis of Plasmodium falciparum transcription

Developmentally-linked gene expression is critical to the success of the human malaria parasite Plasmodium alciparum in ensuring colonisation, adaptation, replication and transmission during its complex life cycle as well as the manifestation of dise... Read More about A spatial and temporal analysis of Plasmodium falciparum transcription.

Structural studies of surfactant protein D in complex with bacterial lipopolysaccharide ligands
Thesis
bacterial lipopolysaccharide ligands

This work is focused on the recognition of natural lipopolysaccharide (LPS) by the innate immune protein human lung surfactant protein D (hSP-D) in the form of a biologically active recombinant fragment (rfhSP-D), containing the a-helical coiled-coil... Read More about Structural studies of surfactant protein D in complex with bacterial lipopolysaccharide ligands.

Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection
Thesis
Channell, J. A. (2019). Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection. Retrieved from https://keele-repository.worktribe.com/output/413133

Cluster of differentiation 4 (CD4) is a receptor protein found on the surface of cells of the immune system and is the primary receptor of the human immuno-deficiency virus-1 (HIV-1) envelope glycoprotein 120 (gp120). The extracellular portion of CD4... Read More about Biophysical studies of dynamic CD4 changes implicated in HIV-1 infection.