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Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. (2015)
Journal Article
Forrester-Soto. (2015). Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage. Frontiers in Microbiology, 1037 - 1037. https://doi.org/10.3389/fmicb.2015.01037

Previous imported cases of Lassa fever (LF) into the United Kingdom from the Ivory Coast and Mali, as well as the detection of Lassa virus (LASV) among the Mastomys natalensis population within Mali has led to the suggestion that the endemic area for... Read More about Lassa virus isolates from Mali and the Ivory Coast represent an emerging fifth lineage..

Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans (2015)
Journal Article
Moura, G., Lucena, S., Andrade De Lima, M., Nascimento, F., Gesteira, T., Nader, H., …Tersariol, I. (2015). Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans. Cell Death Discovery, 1, 15005--15005. https://doi.org/10.1038/cddiscovery.2015.5

Here, we present evidence for the positive allosteric modulation of the P2X7 receptor through glycosaminoglycans (GAGs) in CHO (cell line derived from the ovary of the Chinese hamster) cells. The marked potentiation of P2X7 activity through GAGs in t... Read More about Post-translational allosteric activation of the P2X 7 receptor through glycosaminoglycan chains of CD44 proteoglycans.

Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit (2015)
Journal Article
Masood. (2015). Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit. BMC Genomics, https://doi.org/10.1186/s12864-015-1961-y

Background: Cronobacter sakazakii is a member of the genus Cronobacter that has frequently been isolated from powdered infant formula (PIF) and linked with rare but fatal neonatal infections such as meningitis and necrotising enterocolitis. The Cron... Read More about Genomic dissection of the 1994 Cronobacter sakazakii outbreak in a French neonatal intensive care unit.

A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke (2015)
Journal Article
Wong, R., Pradillo, J. M., Denes, A., Dhungana, H., Malm, T., Koistinaho, J., …Maysami, S. (2015). A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke. Journal of Cerebral Blood Flow and Metabolism, 36(3), 596-605. https://doi.org/10.1177/0271678X15606714

Stroke represents a global challenge and is a leading cause of permanent disability worldwide. Despite much effort, translation of research findings to clinical benefit has not yet been successful. Failure of neuroprotection trials is considered, in... Read More about A cross-laboratory preclinical study on the effectiveness of interleukin-1 receptor antagonist in stroke.

Non-random patterns in viral diversity (2015)
Journal Article
Anthony, S., Islam, A., Johnson, C., Navarrete-Macias, I., Liang, E., Jain, K., …Lipkin, W. (2015). Non-random patterns in viral diversity. Nature communications, https://doi.org/10.1038/ncomms9147

It is currently unclear whether changes in viral communities will ever be predictable. Here we investigate whether viral communities in wildlife are inherently structured (inferring predictability) by looking at whether communities are assembled thro... Read More about Non-random patterns in viral diversity.

The flip side of the other-race coin: They all look different to me (2015)
Journal Article
(2015). The flip side of the other-race coin: They all look different to me. British Journal of Psychology, 374-388. https://doi.org/10.1111/bjop.12147

Poorer recognition of other-race faces than own-races faces has been attributed to a problem of discrimination (i.e., telling faces apart). The conclusion that ‘they all look the same to me' is based on studies measuring the perception/memory of high... Read More about The flip side of the other-race coin: They all look different to me.

Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England (2015)
Journal Article
Wastling. (2015). Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England. Parasites and Vectors, https://doi.org/10.1186/s13071-015-1059-z

Background The protozoan Giardia duodenalis is a common but highly diverse human parasite that comprises a complex of seven morphologically identical genetic assemblages, further divided into sub-assemblages. There is very little information availab... Read More about Determination of Giardia duodenalis assemblages and multi-locus genotypes in patients with sporadic giardiasis from England.

Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context (2015)
Journal Article
Feber, R. E., Johnson, P. J., Bell, J. R., Chamberlain, D. E., Firbank, L. G., Fuller, R. J., …Macdonald, D. W. (2015). Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context. PloS one, 10(8), Article e0135921. https://doi.org/10.1371/journal.pone.0135921

Organic farming, a low intensity system, may offer benefits for a range of taxa, but what affects the extent of those benefits is imperfectly understood. We explored the effects of organic farming and landscape on the activity density and species den... Read More about Organic Farming: Biodiversity Impacts Can Depend on Dispersal Characteristics and Landscape Context.

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. (2015)
Journal Article
(2015). Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax. PLoS Neglected Tropical Diseases, e0003975 - ?. https://doi.org/10.1371/journal.pntd.0003975

The parasitic flagellate Trypanosoma vivax is a cause of animal trypanosomiasis across Africa and South America. The parasite has a digenetic life cycle, passing between mammalian hosts and insect vectors, and a series of developmental forms adapted... Read More about Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax..

Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. (2015)
Journal Article
Maysami, S., Haley, M., Gorenkova, N., Krishnan, S., McColl, B., & Lawrence, C. (2015). Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke. Journal of Neuroinflammation, 140 - ?. https://doi.org/10.1186/s12974-015-0359-8

BACKGROUND: Obesity increases the risk for ischaemic stroke and is associated with worse outcome clinically and experimentally. Most experimental studies have used genetic models of obesity. Here, a more clinically relevant model, diet-induced obesit... Read More about Prolonged diet-induced obesity in mice modifies the inflammatory response and leads to worse outcome after stroke..

Rescue of long-term memory after reconsolidation blockade (2015)
Journal Article
Trent, S., Barnes, P., Hall, J., & Thomas, K. L. (2015). Rescue of long-term memory after reconsolidation blockade. Nature communications, 4, Article 7897. https://doi.org/10.1038/ncomms8897

Memory reconsolidation is considered to be the process whereby stored memories become labile on recall, allowing updating. Blocking the restabilization of a memory during reconsolidation is held to result in a permanent amnesia. The targeted knockdow... Read More about Rescue of long-term memory after reconsolidation blockade.

Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. (2015)
Journal Article
Winter. (2015). Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding. Chemical Science, 6147 - 6157. https://doi.org/10.1039/C5SC02155C

The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential for embryogenesis and for tissue/organ regeneration in post-natal life. HGF/SF-MET signall... Read More about Exploring the chemical space of the lysine-binding pocket of the first kringle domain of hepatocyte growth factor/scatter factor (HGF/SF) yields a new class of inhibitors of HGF/SF-MET binding..

Monoclonal antibodies indicate low-abundance links between heteroxylan and other glycans of plant cell walls. (2015)
Journal Article
Cornuault, V., Buffetto, F., Marcus, S., Xue, J., Crépeau, M., Rydahl, M., …Ralet, M. (2015). Monoclonal antibodies indicate low-abundance links between heteroxylan and other glycans of plant cell walls. Planta, 1321 - 1334. https://doi.org/10.1007/s00425-015-2375-4

MAIN CONCLUSION: The derivation of two sensitive monoclonal antibodies directed to heteroxylan cell wall polysaccharide preparations has allowed the identification of potential inter-linkages between xylan and pectin in potato tuber cell walls and al... Read More about Monoclonal antibodies indicate low-abundance links between heteroxylan and other glycans of plant cell walls..

Highly delayed systemic translocation of aluminium-based adjuvant in CD1 mice following intramuscular injections (2015)
Journal Article
(2015). Highly delayed systemic translocation of aluminium-based adjuvant in CD1 mice following intramuscular injections. Journal of Inorganic Biochemistry, 199-205. https://doi.org/10.1016/j.jinorgbio.2015.07.004

Concerns regarding vaccine safety have emerged following reports of potential adverse events in both humans and animals. In the present study, alum, alum-containing vaccine and alum adjuvant tagged with fluorescent nanodiamonds were used to evaluate... Read More about Highly delayed systemic translocation of aluminium-based adjuvant in CD1 mice following intramuscular injections.

Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis? (2015)
Journal Article
(2015). Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?. International Journal of Developmental Biology, 367 -377. https://doi.org/10.1387/ijdb.140336lf

Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal express... Read More about Na (+)/H (+)exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?.

Large-scale migration synchrony between parasitoids and their host (2015)
Journal Article
PÉREZ-RODRÍGUEZ, J., SHORTALL, C. R., & BELL, J. R. (2015). Large-scale migration synchrony between parasitoids and their host. Ecological Entomology, 40(5), 654-659. https://doi.org/10.1111/een.12241

1. Parasitoids are a valuable group for conservation biological control. In their role as regulators of aphid pests, it is critical that their lifecycle is synchronised with their hosts in both space and time. This is because a synchronised parasitoi... Read More about Large-scale migration synchrony between parasitoids and their host.

Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli (2015)
Journal Article
Gomig, F., Galvão, C. W., Freitas, D. L. D., Labas, L., Etto, R. M., Esmerino, L. A., …Silveira, R. B. D. (2015). Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli. Brazilian Journal of Microbiology, 46(3), 753-757. https://doi.org/10.1590/S1517-838246320131291

Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential rela... Read More about Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.

The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions. (2015)
Journal Article
(2015). The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions. Behavioural Brain Research, 107 -117. https://doi.org/10.1016/j.bbr.2015.03.058

Unilateral 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway produce side-biased motor impairments that reflect the motor deficits seen in Parkinson's disease (PD). This toxin-induced model in the rat has been used widely, to evaluate p... Read More about The 6-OHDA mouse model of Parkinson's disease - Terminal striatal lesions provide a superior measure of neuronal loss and replacement than median forebrain bundle lesions..