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In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes. (2017)
Journal Article
Kareem, N., Yates, E., Skidmore, M., & Hoole, D. (2018). In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes. Fish and Shellfish Immunology, 74, 213-222. https://doi.org/10.1016/j.fsi.2017.12.047

The rapid emergence of drug resistance, unfavourable immunosuppression and mounting evidence to suggest the deleterious accumulation of drug breakdown residues within animal tissues has driven a strong desire to move away from these current methods o... Read More about In vitro investigations on the effects of semi-synthetic, sulphated carbohydrates on the immune status of cultured common carp (Cyprinus carpio) leucocytes..

Localization of Cholesterol within Supported Lipid Bilayers Made of a Natural Extract of Tailor-Deuterated Phosphatidylcholine. (2017)
Journal Article
(2017). Localization of Cholesterol within Supported Lipid Bilayers Made of a Natural Extract of Tailor-Deuterated Phosphatidylcholine. Langmuir, 472 - 479. https://doi.org/10.1021/acs.langmuir.7b02716

Cholesterol is an essential component of mammalian membranes and is known to induce a series of physicochemical changes in the lipid bilayer. Such changes include the formation of liquid-ordered phases with an increased thickness and a configurationa... Read More about Localization of Cholesterol within Supported Lipid Bilayers Made of a Natural Extract of Tailor-Deuterated Phosphatidylcholine..

A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning (2017)
Journal Article
Crawley, O., Giles, A. C., Desbois, M., Kashyap, S., Birnbaum, R., & Grill, B. (2017). A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning. PLOS genetics, 13(12), Article e1007095. https://doi.org/10.1371/journal.pgen.1007095

The Pam/Highwire/RPM-1 (PHR) proteins are conserved intracellular signaling hubs that regulate synapse formation and axon termination. The C. elegans PHR protein, called RPM-1, acts as a ubiquitin ligase to inhibit the DLK-1 and MLK-1 MAP kinase path... Read More about A MIG-15/JNK-1 MAP kinase cascade opposes RPM-1 signaling in synapse formation and learning.

Chemical Ecology (2017)
Book Chapter
Bruce. (2017). Chemical Ecology. In Aphids as Crop Pests (148-172)

Novel role of Vpmas as major adhesins of Mycoplasma agalactiae mediating differential cell adhesion and invasion of Vpma expression variants (2017)
Journal Article
Hegde, S., Zimmermann, M., Rosengarten, R., & Chopra-Dewasthaly, R. (2018). Novel role of Vpmas as major adhesins of Mycoplasma agalactiae mediating differential cell adhesion and invasion of Vpma expression variants. International Journal of Medical Microbiology, 308(2), 263-270. https://doi.org/10.1016/j.ijmm.2017.11.010

Mycoplasma agalactiae exhibits antigenic variation by switching the expression of multiple surface lipoproteins called Vpmas. Although implicated to have a significant influence on the pathogenicity, their exact role in pathogen-host interactions has... Read More about Novel role of Vpmas as major adhesins of Mycoplasma agalactiae mediating differential cell adhesion and invasion of Vpma expression variants.

The sensitivity of breeding songbirds to changes in seasonal timing is linked to population change but cannot be directly attributed to the effects of trophic asynchrony on productivity (2017)
Journal Article
Franks, S. E., Pearce-Higgins, J. W., Atkinson, S., Bell, J. R., Botham, M. S., Brereton, T. M., Harrington, R., & Leech, D. I. (2018). The sensitivity of breeding songbirds to changes in seasonal timing is linked to population change but cannot be directly attributed to the effects of trophic asynchrony on productivity. Global Change Biology, 24(3), 957-971. https://doi.org/10.1111/gcb.13960

A consequence of climate change has been an advance in the timing of seasonal events. Differences in the rate of advance between trophic levels may result in predators becoming mismatched with prey availability, reducing fitness and potentially drivi... Read More about The sensitivity of breeding songbirds to changes in seasonal timing is linked to population change but cannot be directly attributed to the effects of trophic asynchrony on productivity.

Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning (2017)
Journal Article
Clifton, N. E., Cameron, D., Trent, S., Sykes, L. H., Thomas, K. L., & Hall, J. (2017). Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. Neural Plasticity, 2014, 1 - 11. https://doi.org/10.1155/2017/5959182

<jats:p>Genes involved in synaptic plasticity, particularly genes encoding postsynaptic density proteins, have been recurrently linked to psychiatric disorders including schizophrenia and autism. Postsynaptic density Homer1 proteins contribute to syn... Read More about Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning.

Analysis of XFEL serial diffraction data from individual crystalline fibrils (2017)
Journal Article
(2017). Analysis of XFEL serial diffraction data from individual crystalline fibrils. IUCrJ, 795 -811. https://doi.org/10.1107/S2052252517014324

Serial diffraction data collected at the Linac Coherent Light Source from crystalline amyloid fibrils delivered in a liquid jet show that the fibrils are well oriented in the jet. At low fibril concentrations, diffraction patterns are recorded from s... Read More about Analysis of XFEL serial diffraction data from individual crystalline fibrils.

Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis (2017)
Journal Article
(2017). Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis. EBioMedicine, 60-67. https://doi.org/10.1016/j.ebiom.2017.10.028

AbstractBackground Progressive multiple sclerosis is a chronic autoimmune condition of unknown aetiology and few therapeutic options. Human exposure to aluminium has been linked with multiple sclerosis and affected individuals are known to excrete un... Read More about Urinary Excretion of Aluminium and Silicon in Secondary Progressive Multiple Sclerosis.

In vivo analysis of the Escherichia coli ultrastructure by small-angle scattering (2017)
Journal Article
(2017). In vivo analysis of the Escherichia coli ultrastructure by small-angle scattering. IUCrJ, 751 -757. https://doi.org/10.1107/S2052252517013008

The flagellated Gram-negative bacterium Escherichia coli is one of the most studied microorganisms. Despite extensive studies as a model prokaryotic cell, the ultrastructure of the cell envelope at the nanometre scale has not been fully elucidated. H... Read More about In vivo analysis of the Escherichia coli ultrastructure by small-angle scattering.

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion (2017)
Journal Article
Russo, I. (2017). Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion. Science, 518 - 522. https://doi.org/10.1126/science.aan1478

Proteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied e... Read More about Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion.

Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase (2017)
Journal Article
Stevens, E., Laabei, M., Gardner, S., Somerville, G. A., & Massey, R. C. (2017). Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase. Scientific reports, 7(1), https://doi.org/10.1038/s41598-017-14110-8

Staphylococcus aureus is a medically important pathogen with an abundance of virulence factors that are necessary for survival within a host, including the production of cytolytic toxins. The regulation of toxin production is mediated by the Agr quor... Read More about Cytolytic toxin production by Staphylococcus aureus is dependent upon the activity of the protoheme IX farnesyltransferase.

A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence (2017)
Journal Article
Skidmore, M., Mohd Fadzli Mustaffa, K., Cooper, L. C., Guimond, S. E., Yates, E. A., & Craig, A. G. (2017). A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence. PloS one, 12(10), Article e0186276. https://doi.org/10.1371/journal.pone.0186276

A feature of mature Plasmodium falciparum parasitized red blood cells is their ability to bind surface molecules of the microvascular endothelium via the parasite-derived surface protein Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).... Read More about A semi-synthetic glycosaminoglycan analogue inhibits and reverses Plasmodium falciparum cytoadherence.

Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III (2017)
Journal Article
(2017). Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III. Scientific reports, https://doi.org/10.1038/s41598-017-13620-9

Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene (CLRN1). Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf by P21-P25. Early onse... Read More about Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III.

Biological Flora of the British Isles: Sorbus torminalis (2017)
Journal Article
(2017). Biological Flora of the British Isles: Sorbus torminalis. Journal of Ecology, 1806-1831. https://doi.org/10.1111/1365-2745.12857

1.This account presents information on all aspects of the biology of Sorbus torminalis (L.) Crantz (Wild Service-tree) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard... Read More about Biological Flora of the British Isles: Sorbus torminalis.

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito (2017)
Journal Article
M. Hammond, A., Kyrou, K., Bruttini, M., North, A., Galizi, R., Karlsson, X., Kranjc, N., M. Carpi, F., D’Aurizio, R., Crisanti, A., & Nolan, T. (2017). The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito. PLoS Genetics, e1007039 - ?. https://doi.org/10.1371/journal.pgen.1007039

Gene drives have enormous potential for the control of insect populations of medical and agricultural relevance. By preferentially biasing their own inheritance, gene drives can rapidly introduce genetic traits even if these confer a negative fitness... Read More about The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.

Microclimatic temperatures of Danish cattle farms: a better understanding of the variation in transmission potential of Schmallenberg virus (2017)
Presentation / Conference Contribution
Haider, N., Carolina Cuellar, A., Jung Kjær, L., Havskov Sørensen, J., & Bødker, R. (2017, September). Microclimatic temperatures of Danish cattle farms: a better understanding of the variation in transmission potential of Schmallenberg virus. Paper presented at 11th EPIZONE Annual Meeting, Cité des Science et de l’ índustrie, Parc de la Vilette, Paris, France

Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK. (2017)
Journal Article
(2017). Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK. Neuropathology and Applied Neurobiology, 537-541. https://doi.org/10.1111/nan.12417

The possible role of aluminium in the pathogenesis of Alzheimer's disease (AD) has been hotly debated over the past few decades. Although the so-called ‘aluminium hypothesis’ was popular in the 1970s and 1980s, it has gradually fallen out of favour i... Read More about Unusual neuropathological features and increased brain aluminium in a resident of Camelford, UK..