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All Outputs (87)

Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes. (2018)
Journal Article
Bernardini, F., Elaine Haghighat-Khah, R., Galizi, R., Marc Hammond, A., Nolan, T., & Crisanti, A. (2018). Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes. Parasites and Vectors, 660 - ?. https://doi.org/10.1186/s13071-018-3207-8

Malaria is a serious global health burden, affecting more than 200 million people each year in over 90 countries, predominantly in Africa, Asia and the Americas. Since the year 2000, a concerted effort to combat malaria has reduced its incidence by m... Read More about Molecular tools and genetic markers for the generation of transgenic sexing strains in Anopheline mosquitoes..

A perspective on the need and current status of efficient sex separation methods for mosquito genetic control. (2018)
Journal Article
(2018). A perspective on the need and current status of efficient sex separation methods for mosquito genetic control. Parasites and Vectors, 654 - ?. https://doi.org/10.1186/s13071-018-3222-9

Major efforts are currently underway to develop novel, complementary methods to combat mosquito-borne diseases. Mosquito genetic control strategies (GCSs) have become an increasingly important area of research on account of their species-specificity,... Read More about A perspective on the need and current status of efficient sex separation methods for mosquito genetic control..

Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1 (2018)
Journal Article
Drizou, F., Bruce, T. J. A., Ray, R. V., & Graham, N. S. (2018). Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1. Frontiers in Plant Science, 9, Article ARTN 1903. https://doi.org/10.3389/fpls.2018.01903

Activation of plant defense pathways can be influenced by the presence of different species of attacking organisms. Understanding the complicated interactions triggering plant defense mechanisms is of great interest as it may allow the development of... Read More about Infestation by Myzus persicae Increases Susceptibility of Brassica napus cv. "Canard" to Rhizoctonia solani AG 2-1.

The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells (2018)
Journal Article
Geng, R., Furness, D. N., Muraleedharan, C. K., Zhang, J., Dabdoub, A., Lin, V., & Xu, S. (2018). The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells. Scientific reports, 8, 18022 - ?. https://doi.org/10.1038/s41598-018-36894-z

The microRNA (miR)-183/96/182 cluster plays important roles in the development and functions of sensory organs, including the inner ear. Point-mutations in the seed sequence of miR-96 result in non-syndromic hearing loss in both mice and humans. Howe... Read More about The microRNA-183/96/182 Cluster is Essential for Stereociliary Bundle Formation and Function of Cochlear Sensory Hair Cells.

Insect population trends and the IUCN Red List process (2018)
Journal Article
Fox, R., Harrower, C. A., Bell, J. R., Shortall, C. R., Middlebrook, I., & Wilson, R. J. (2018). Insect population trends and the IUCN Red List process. Journal of Insect Conservation, 23, 269–278. https://doi.org/10.1007/s10841-018-0117-1

Reliable assessment of extinction risk is a key factor in the preparation of Red Lists and in prioritizing biodiversity conservation. Temporal population trends can provide important evidence for such assessments, but imperfect sampling (observation... Read More about Insect population trends and the IUCN Red List process.

Evidence for a southward autumn migration of nocturnal noctuid moths in central Europe. (2018)
Journal Article
Dreyer, D., el Jundi, B., Kishkinev, D., Suchentrunk, C., Campostrini, L., Frost, B. J., …Warrant, E. J. (2018). Evidence for a southward autumn migration of nocturnal noctuid moths in central Europe. Journal of Experimental Biology, https://doi.org/10.1242/jeb.179218

Insect migrations are spectacular natural events and resemble a remarkable relocation of biomass between two locations in space. Unlike the well-known migrations of daytime flying butterflies, such as the painted lady (Vanessa cardui) or the monarch... Read More about Evidence for a southward autumn migration of nocturnal noctuid moths in central Europe..

Novel wolbachia strains in anopheles malaria vectors from sub-saharan africa [version 2; referees: 3 approved] (2018)
Journal Article
Jeffries, C. L., Lawrence, G. G., Golovko, G., Kristan, M., Orsborne, J., Spence, K., …Walker, T. (2018). Novel wolbachia strains in anopheles malaria vectors from sub-saharan africa [version 2; referees: 3 approved]. Wellcome Open Research, 3(113), https://doi.org/10.12688/wellcomeopenres.14765.2

Background: Wolbachia, a common insect endosymbiotic bacterium that can influence pathogen transmission and manipulate host reproduction, has historically been considered absent from the Anopheles (An.) genera, but has recently been found in An. gamb... Read More about Novel wolbachia strains in anopheles malaria vectors from sub-saharan africa [version 2; referees: 3 approved].

Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin (2018)
Journal Article
(2018). Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin. Communications Biology, https://doi.org/10.1038/s42003-018-0203-7

Plasma-membrane Ca(2+)-ATPases expel Ca(2+) from the cytoplasm and are key regulators of Ca(2+) homeostasis in eukaryotes. They are autoinhibited under low Ca(2+) concentrations. Calmodulin (CaM)-binding to a unique regulatory domain releases the aut... Read More about Structural basis for activation of plasma-membrane Ca(2+)-ATPase by calmodulin.

Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line (2018)
Journal Article
Haga, I. R., Simpson, J. L., Hawes, P. C., & Beard, P. M. (2018). Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line. Scientific Reports, 8, Article 16956. https://doi.org/10.1038/s41598-018-34732-w

The re-emergence of poxviral zoonotic infections and the threat of bioterrorism emphasise the demand
for efective antipoxvirus therapies. Here, we show that carbenoxolone, a pharmacological inhibitor of
gap junction function and a compound widely... Read More about Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line.

The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach (2018)
Journal Article
Haider, N., Laaksonen, S., Kjær, L. J., Oksanen, A., & Bødker, R. (in press). The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach. Parasites and Vectors, 11, Article 565. https://doi.org/10.1186/s13071-018-3159-z

Background
In northern Finland (Lapland), reindeer are reared as semi-domesticated animals. The region has a short summer season of 2–3 months, yet reindeer are infected with the mosquito-borne filarioid parasite Setaria tundra. The infection causes... Read More about The annual, temporal and spatial pattern of Setaria tundra outbreaks in Finnish reindeer: a mechanistic transmission model approach.

Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action (2018)
Journal Article
(2018). Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action. Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology, https://doi.org/10.1186/s13223-018-0305-2

Aluminium salts are by far the most commonly used adjuvants in vaccines. There are only two aluminium salts which are used in clinically-approved vaccines, Alhydrogel® and AdjuPhos®, while the novel aluminium adjuvant used in Gardasil® is a sulphated... Read More about Unraveling the enigma: elucidating the relationship between the physicochemical properties of aluminium-based adjuvants and their immunological mechanisms of action.

RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge? (2018)
Journal Article
(2018). RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?. Viruses, https://doi.org/10.3390/v10110600

RNA viruses replicate with low fidelity due to the error-prone nature of the RNA-dependent RNA polymerase, which generates approximately one mutation per round of genome replication. Due to the large population sizes produced by RNA viruses during re... Read More about RNA virus fidelity mutants: a useful tool for evolutionary biology or a complex challenge?.

Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris) (2018)
Journal Article
(2018). Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris). PloS one, https://doi.org/10.1371/journal.pone.0204612

Gut microbial communities are critical for the health of many insect species. However, little is known about how gut microbial communities respond to anthropogenic changes and how such changes affect host-pathogen interactions. In this study, we used... Read More about Habitat-specific variation in gut microbial communities and pathogen prevalence in bumblebee queens (Bombus terrestris).

Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. (2018)
Journal Article
(2018). Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density. Malaria Journal, 377. https://doi.org/10.1186/s12936-018-2530-z

BACKGROUND: In a context of increasing resistance of both vectors toward main classes of insecticides used in public health and parasites toward anti-malarial drugs, development of new and complementary molecules or control approaches is fundamental... Read More about Assessment of the developmental success of Anopheles coluzzii larvae under different nutrient regimes: effects of diet quality, food amount and larval density..

Simultaneous Detection of Ammonium and Nitrate in Environmental Samples Using on Ion-Selective Electrode and Comparison with Portable Colorimetric Assays (2018)
Journal Article
(2018). Simultaneous Detection of Ammonium and Nitrate in Environmental Samples Using on Ion-Selective Electrode and Comparison with Portable Colorimetric Assays. Sensors, https://doi.org/10.3390/s18103555

Simple, robust, and low-cost nitrate- and ammonium-selective electrodes were made using substrate prepared from household materials. We explored phosphonium-based ILs and poly (methyl methacrylate)/poly(decyl methacrylate)(MMA-DMA) copolymer as matri... Read More about Simultaneous Detection of Ammonium and Nitrate in Environmental Samples Using on Ion-Selective Electrode and Comparison with Portable Colorimetric Assays.

Is callose required for silicification in plants? (2018)
Journal Article
(2018). Is callose required for silicification in plants?. Biology Letters, https://doi.org/10.1098/rsbl.2018.0338

The cell wall polymer callose catalyses the formation of silica in vitro and is heavily implicated in biological silicification in Equisetum (horsetail) and Arabidopsis (thale cress) in vivo Callose, a ß-1,3-glucan, is an ideal partner for silicifica... Read More about Is callose required for silicification in plants?.

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. (2018)
Journal Article
(2018). Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature communications, 4015 - ?. https://doi.org/10.1038/s41467-018-06307-w

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are ope... Read More about Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation..

Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation (2018)
Journal Article
(2018). Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation. Nature communications, https://doi.org/10.1038/s41467-018-06307

In the adult auditory organ, mechanoelectrical transducer (MET) channels are essential for transducing acoustic stimuli into electrical signals. In the absence of incoming sound, a fraction of the MET channels on top of the sensory hair cells are ope... Read More about Mechanotransduction is required for establishing and maintaining mature inner hair cells and regulating efferent innervation.