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Comparison of swarming, mating performance and longevity of males Anopheles coluzzii between individuals fed with different natural fruit juices in laboratory and semi-field conditions. (2020)
Journal Article
(2020). Comparison of swarming, mating performance and longevity of males Anopheles coluzzii between individuals fed with different natural fruit juices in laboratory and semi-field conditions. Malaria Journal, 173 - ?. https://doi.org/10.1186/s12936-020-03248-y

BACKGROUND: It is assumed that malaria vectors feed on locally available nectar sources to obtain energy. Sugar feeding is energetically critical for the Anopheles male swarming and mating activities. However, little is known about the impact of loca... Read More about Comparison of swarming, mating performance and longevity of males Anopheles coluzzii between individuals fed with different natural fruit juices in laboratory and semi-field conditions..

Effects of body size on estimation of mammalian area requirements (2020)
Journal Article
(2020). Effects of body size on estimation of mammalian area requirements. Conservation Biology, https://doi.org/10.1111/cobi.13495

Accurately quantifying species’ area requirements is a prerequisite for effective area-based conservation. This typically involves collecting tracking data on species of interest and then conducting home-range analyses. Problematically, autocorrelati... Read More about Effects of body size on estimation of mammalian area requirements.

Imaging of aluminium and amyloid ß in neurodegenerative disease. (2020)
Journal Article
(2020). Imaging of aluminium and amyloid ß in neurodegenerative disease. Heliyon, https://doi.org/10.1016/j.heliyon.2020.e03839

Objectives: Recent research has confirmed the presence of aluminium in human brain tissue. Quantitative analyses suggest increased brain aluminium content in a number of neurodegenerative diseases including familial Alzheimer's disease, congophilic a... Read More about Imaging of aluminium and amyloid ß in neurodegenerative disease..

Visualising Silicon in Plants: Histochemistry, Silica Sculptures and Elemental Imaging. (2020)
Journal Article
(2020). Visualising Silicon in Plants: Histochemistry, Silica Sculptures and Elemental Imaging. Cells, https://doi.org/10.3390/cells9041066

Silicon is a non-essential element for plants and is available in biota as silicic acid. Its presence has been associated with a general improvement of plant vigour and response to exogenous stresses. Plants accumulate silicon in their tissues as amo... Read More about Visualising Silicon in Plants: Histochemistry, Silica Sculptures and Elemental Imaging..

Behavioural and Electrophysiological Responses of Female Anopheles gambiae Mosquitoes to Volatiles from a Mango Bait (2020)
Journal Article
Okumu, F., Tripet, F., Bruce, T., Sobhy, I., Roberts, J., & Meza, F. (2020). Behavioural and Electrophysiological Responses of Female Anopheles gambiae Mosquitoes to Volatiles from a Mango Bait. Journal of Chemical Ecology, 387-396. https://doi.org/10.1007/s10886-020-01172-8

Attractive Toxic Sugar Baits (ATSB) are used in a "lure-and-kill" approach for management of the malaria vector Anopheles gambiae, but the active chemicals were previously unknown. Here we collected volatiles from a mango, Mangifera indica, juice bai... Read More about Behavioural and Electrophysiological Responses of Female Anopheles gambiae Mosquitoes to Volatiles from a Mango Bait.

Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations (2020)
Working Paper
Hammond, A. M., Kyrou, K., Gribble, M., Karlsson, X., Morianou, I., Galizi, R., …Nolan, T. Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations

Abstract CRISPR-based genes drives bias their own inheritance and can be used to modify entire populations of insect vectors of disease as a novel form of sustainable disease control. Gene drives designed to interfere with female fertility can suppre... Read More about Improved CRISPR-based suppression gene drives mitigate resistance and impose a large reproductive load on laboratory-contained mosquito populations.

Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells (2020)
Thesis
Grimes, D. (2020). Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells. (Thesis). Keele University

Pro-inflammatory cytokines and glucolipotoxicity are known mediators of beta cell death and dysfunction in the pathogenesis of type 1 and type 2 diabetes mellitus (DM). In contrast to the pro-apoptotic effects of long-chain saturated fatty acids in b... Read More about Cytoprotective effects of epoxyeicosatrienoic acids in pancreatic beta cells.

Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model (2020)
Thesis
Whittle, E. L. (2020). Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model. (Thesis). Keele University

Asthma is one of the most common chronic diseases of the 21st century, affecting over 300 million people worldwide 1. It is an inflammatory disorder of the airways that is a major public concern globally due to increasing prevalence and rates of mort... Read More about Molecular characterisation of human atopic asthma and house dust mite induced pulmonary inflammation in a murine experimental model.

The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells (2020)
Thesis
Mohammed, S. N. (2020). The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells. (Thesis). Keele University

Background and aims: Aggressiveness and invasiveness of breast cancer are influenced by multiple cellular and molecular factors, some of which are yet to be elucidated. In normal cells, vacuolar H (+) -ATPase (V ATPases), which pump protons across th... Read More about The role of ATP6V1E1 in the control of apoptosis, survival and motility of breast cancer cells.

Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes (2020)
Thesis
Osborn, A. H. (2020). Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes. (Thesis). Keele University

Fibrocyte degeneration in the cochlear lateral wall is one possible pathology of age-related metabolic hearing loss (presbyacusis). Fibrocytes play a role in potassium recycling and maintenance of the endocochlear potential (EP). It has been proposed... Read More about Evaluation of cultured cochlear fibrocytes as a cell replacement therapy: comparison with native fibrocytes.

A diagnostic real-time PCR assay for the rapid identification of the tomato-potato psyllid, Bactericera cockerelli (Šulc, 1909) and development of a psyllid barcoding database (2020)
Journal Article
Sumner-Kalkun, J., Sjölund, M., Arnsdorf, Y., Carnegie, M., Highet, F., Ouvrard, D., …Kenyon, D. (2020). A diagnostic real-time PCR assay for the rapid identification of the tomato-potato psyllid, Bactericera cockerelli (Šulc, 1909) and development of a psyllid barcoding database. PloS one, 15(3), Article e0230741. https://doi.org/10.1371/journal.pone.0230741

The accurate and rapid identification of insect pests is an important step in the prevention and control of outbreaks in areas that are otherwise pest free. The potato-tomato psyllid Bactericera cockerelli (Šulc, 1909) is the main vector of ‘Candidat... Read More about A diagnostic real-time PCR assay for the rapid identification of the tomato-potato psyllid, Bactericera cockerelli (Šulc, 1909) and development of a psyllid barcoding database.

Lead Optimization of Dehydroemetine for Repositioned Use in Malaria. (2020)
Journal Article
(2020). Lead Optimization of Dehydroemetine for Repositioned Use in Malaria. Antimicrobial Agents and Chemotherapy, https://doi.org/10.1128/AAC.01444-19

Drug repositioning offers an effective alternative to de novo drug design to tackle the urgent need for novel antimalarial treatments. The antiamoebic compound emetine dihydrochloride has been identified as a potent in vitro inhibitor of the multidru... Read More about Lead Optimization of Dehydroemetine for Repositioned Use in Malaria..

Microbiome: Evolution in a World of Interaction. (2020)
Journal Article
King, K. C., Stevens, E., & Drew, G. C. (2020). Microbiome: Evolution in a World of Interaction. Current Biology, 30(6), R265-R267. https://doi.org/10.1016/j.cub.2020.02.010

Ecological interactions can generate strong selection. Two new studies reveal that the tempo and patterns of evolutionary change in a mammalian gut commensal can be altered dramatically during interactions with both the host and its microbiome.

Application of the Random Encounter Model in citizen science projects to monitor animal densities (2020)
Journal Article
(2020). Application of the Random Encounter Model in citizen science projects to monitor animal densities. Remote Sensing in Ecology and Conservation, https://doi.org/10.1002/rse2.153

Abundance and density are vital metrics for assessing a species’ conservation status and for developing effective management strategies. Remote-sensing cameras are being used increasingly as part of citizen science projects to monitor wildlife, but c... Read More about Application of the Random Encounter Model in citizen science projects to monitor animal densities.

Genetic structure of regional water vole populations and footprints of reintroductions: a case study from southeast England (2020)
Journal Article
(2020). Genetic structure of regional water vole populations and footprints of reintroductions: a case study from southeast England. Conservation Genetics, https://doi.org/10.1007/s10592-020-01268-4

An important consideration when implementing species management is preserving genetic variation, which is fundamental to the long-term persistence of populations and adaptive potential of the species. The European water vole Arvicola amphibius is of... Read More about Genetic structure of regional water vole populations and footprints of reintroductions: a case study from southeast England.

Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model (2020)
Journal Article
Paape, D., Prendergast, C., Price, H., Doehl, J., & Smith, D. (2020). Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model. Parasites and Vectors, 13, Article 132. https://doi.org/10.1186/s13071-020-3999-1

Background: Proving that specifc genes are essential for the intracellular viability of Leishmania parasites within macrophages remains a challenge for the identifcation of suitable targets for drug development. This is especially evident in the ab... Read More about Genetic validation of Leishmania genes essential for amastigote survival in vivo using N-myristoyltransferase as a model.

Rothamsted Insect Survey, Moth and Aphid catch abundance data (2020)
Dataset
Bell, J., Blumgart, D., & Shortall, C. (2020). Rothamsted Insect Survey, Moth and Aphid catch abundance data. [Dataset]. https://doi.org/10.23637/rothamsted.975qz

This dataset contains Moth and Aphid catch abundance data from the Rothamsted Insect Survey light-trap and suction trap networks. The dataset is a supplement to Bell et al (2020) (https://doi.org/10.1111/icad.12412) and can be used to reproduce the R... Read More about Rothamsted Insect Survey, Moth and Aphid catch abundance data.

Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model (2020)
Journal Article
Agostino, V., Trinconi, C., Galuppo, M., Price, H., & Uliana, S. (2020). Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model. Acta tropica, 206, Article 105444. https://doi.org/10.1016/j.actatropica.2020.105444

New drugs for the treatment of human leishmaniasis are urgently needed, considering the limitations of current available options. However, pre-clinical evaluation of drug candidates for leishmaniasis is challenging. The use of luciferase-expressing p... Read More about Evaluation of NanoLuc, RedLuc and Luc2 as bioluminescent reporters in a cutaneous leishmaniasis model.

Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics. (2020)
Journal Article
Mira, A., Codina, H., Jenkins, S., Rodriguez-Diaz, J., Mallavia, R., Falco, A., & Sainz-Urruela, C. (2020). Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics. Nanomaterials, https://doi.org/10.3390/nano10030486

Recent advances in the field of nanotechnology such as nanoencapsulation offer new biomedical applications, potentially increasing the scope and efficacy of therapeutic drug delivery. In addition, the discovery and development of novel biocompatible... Read More about Physico-Chemically Distinct Nanomaterials Synthesized from Derivates of a Poly(Anhydride) Diversify the Spectrum of Loadable Antibiotics..