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The Role of Plant Latex in Virus Biology (2023)
Journal Article
Merchán-Gaitán, J. B., Mendes, J. H. L., Nunes, L. E. C., Buss, D. S., Rodrigues, S. P., & Fernandes, P. M. B. (in press). The Role of Plant Latex in Virus Biology. Viruses, 16(1), Article 47. https://doi.org/10.3390/v16010047

At least 20,000 plant species produce latex, a capacity that appears to have evolved independently on numerous occasions. With a few exceptions, latex is stored under pressure in specialized cells known as laticifers and is exuded upon injury, leadin... Read More about The Role of Plant Latex in Virus Biology.

Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs (2023)
Journal Article
Williams, H. M., Moeller, J. B., Burns, I., Schlosser, A., Sorensen, G. L., Greenhough, T. J., …Shrive, A. K. (2023). Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs. Journal of Biological Chemistry, 105552. https://doi.org/10.1016/j.jbc.2023.105552

Fibrinogen C-domain containing-1 (FIBCD1) is an immune protein proposed to be involved in host recognition of chitin on the surface of pathogens. As FIBCD1 readily binds to acetylated molecules, we have determined the high-resolution crystal structur... Read More about Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen associated carbohydrate motifs.

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., …Cosgrove, S. C. (2023). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300752. https://doi.org/10.1002/cbic.202300752

Wahart et al. demonstrate the use of an immobilised oxidase enzyme coupled to an extractive amino resin for the bioremediation of a common industrial surfactant. This allows the facile purification of alkyl monoglucosides without the need for high en... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides.

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. (2023)
Journal Article
Hoolachan, J. M., McCallion, E., Sutton, E. R., Çetin, Ö., Pacheco-Torres, P., Dimitriadi, M., …Bowerman, M. (2023). A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. Human molecular genetics, ddad192. https://doi.org/10.1093/hmg/ddad192

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly slow down disease progres... Read More about A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models..

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. (2023)
Journal Article
Mogas Barcons, A., Chari, D. M., & Adams, C. (in press). In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. Alternatives to animal experimentation : a journal for new paths in biomedical science / edited by the Swiss Society ALTEX Edition, 41(2), 202-212. https://doi.org/10.14573/altex.2304171

Effective repair of spinal cord injury sites remains a major clinical challenge. One promising strategy is the implantation of multifunctional bioscaffolds to enhance nerve fibre growth, guide regenerating tissue and modulate scarring/inflammation pr... Read More about In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation..

Bangladesh's 2023 Dengue outbreak – age/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens (2023)
Journal Article
Haider, N., Asaduzzaman, M., Nayeem Hasan, M., Rahman, M., Raihan Sharif, A., Ali Akbar Ashrafi, S., …Zumla, A. (2023). Bangladesh's 2023 Dengue outbreak – age/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens. GreSIS - Greater South Information System, https://doi.org/10.60692/gfy0q-qb243

Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment (2023)
Thesis
Ottih, E. C. (2023). Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment. (Thesis). Keele University

Genetic Mosquito mass release is a promising tool in the suppression of wild Anopheles gambiae sensu lato mosquitoes as part of malaria control in Africa. This tool requires a plethora number of eggs and a strain with good fitness. Thus, the success... Read More about Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment.

Shedding off-the-grid: The role of garment manufacturing and textile care in global microfibre pollution (2023)
Journal Article
Stanton, T., Stanes, E., Gwinnett, C., Lei, X., Cauilan-Cureg, M., Ramos, M., …McKay, D. (2023). Shedding off-the-grid: The role of garment manufacturing and textile care in global microfibre pollution. Journal of Cleaner Production, 428, Article 139391. https://doi.org/10.1016/j.jclepro.2023.139391

Textile fibres are abundant anthropogenic pollutants. These fibres enter aquatic, terrestrial, and atmospheric environments, and biota. Textile fibres pose biological and chemical threats to the environments they pollute. Laundry is a primary source... Read More about Shedding off-the-grid: The role of garment manufacturing and textile care in global microfibre pollution.

Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review (2023)
Journal Article
Watford, T., & Masood, N. (2023). Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review. Clinical Psychopharmacology and Neuroscience, 22(1), 2-12. https://doi.org/10.9758/cpn.23.1120

Psilocybin is a classical psychedelic which has been utilised for healing purposes for millenia. However, with its classification as a Schedule I substance, research into this compound is scarce with few FDA-approved clinical studies. Despite this, p... Read More about Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review.

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., …Cosgrove, S. C. (in press). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300625. https://doi.org/10.1002/cbic.202300625

As the world moves towards net-zero carbon emissions, the development of sustainable chemical manufacturing processes is essential. Within manufacturing, purification by distillation is often used, however this process is energy intensive and methods... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides..

History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines (2023)
Journal Article
Rustia, J. M., Antonino, J. P., Velasco, R. R., Lima, M. A., Yates, E. A., & Fernig, D. G. (in press). History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines. Fishes, 8(10), Article 493. https://doi.org/10.3390/fishes8100493

The windowpane oyster Placuna placenta lives in brackish coastal waters and has long been economically important to the Philippines because of its durable and translucent shell, which is used as a glass substitute and material for making windowpanes... Read More about History and Prospects for the Sustainability and Circularity of the Windowpane Oyster Placuna placenta Fishery in the Philippines.

Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects that Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells (2023)
Journal Article
Pagani, I., Ottoboni, L., Panina-Bordignon, P., Martino, G., Poli, G., Taylor, S., …Vicenzi, E. (in press). Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects that Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells. Pharmaceuticals, 16(10), Article 1385. https://doi.org/10.3390/ph16101385

Zika virus (ZIKV) infection during pregnancy can result in severe birth defects, such as microcephaly, as well as a range of other related health complications. Heparin, a clinical-grade anticoagulant, is shown to protect neural progenitor cells from... Read More about Heparin Precursors with Reduced Anticoagulant Properties Retain Antiviral and Protective Effects that Potentiate the Efficacy of Sofosbuvir against Zika Virus Infection in Human Neural Progenitor Cells.

Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites: An In Vitro Study (2023)
Journal Article
Jarkov, V., Waqar, I., Penev, A., Bowen, C., Adams, C., & Khanbareh, H. (in press). Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites: An In Vitro Study. Advanced engineering materials, 25(23), Article 2300696. https://doi.org/10.1002/adem.202300696

Spinal cord injuries can cause permanent tissue damage with debilitating and lasting effects on patients. Electrical stimulation has been established as an effective approach for promoting neural regeneration. However, the clinical applicability of t... Read More about Enhancing Neural Stem Cell Stimulation with Structured Piezoelectric Composites: An In Vitro Study.

Characterization of the swarming behavior of Anopheles coluzzii and Anopheles gambiae (Diptera: Culicidae) populations in a hybrid zone of Senegal. (2023)
Journal Article
Gueye, O. K., Niang, A., Faye, M. B., Dia, A. K., Ahmed, A. A., Sy, O., …Niang, E. H. A. (in press). Characterization of the swarming behavior of Anopheles coluzzii and Anopheles gambiae (Diptera: Culicidae) populations in a hybrid zone of Senegal. Journal of Medical Entomology, 60(6), 1278–1287. https://doi.org/10.1093/jme/tjad120

Anopheles gambiae and Anopheles coluzzii, often found in sympatry and synchronous, have undergone a premating reproductive isolation across their distribution range. However, in the Western coast of Africa, unexpected hybridization zones have been ob... Read More about Characterization of the swarming behavior of Anopheles coluzzii and Anopheles gambiae (Diptera: Culicidae) populations in a hybrid zone of Senegal..

Bangladesh's 2023 Dengue outbreak – age/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens (2023)
Journal Article
Haider, N., Asaduzzaman, M., Hasan, M. N., Rahman, M., Sharif, A. R., Ashrafi, S. A. A., …Zumla, A. (2023). Bangladesh's 2023 Dengue outbreak – age/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens. International Journal of Infectious Diseases, 136, 1-4. https://doi.org/10.1016/j.ijid.2023.08.026

Bangladesh is currently grappling to control its most devastating dengue fever outbreak recorded since the dengue virus (DENV) reappeared in the country in 2000 [1, 2, 3]. Although dengue is endemic in Bangladesh, the current dengue surge is unusual... Read More about Bangladesh's 2023 Dengue outbreak – age/gender-related disparity in morbidity and mortality and geographic variability of epidemic burdens.

Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors † (2023)
Journal Article
Dolan, J., Ahmadipour, S., Wahart, A., Ni Cheallaigh, A., Sari, S., Eurtivong,, C., …Miller, G. (2023). Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors †. RSC Chemical Biology, 4(11), 865-870. https://doi.org/10.1039/D3CB00126A

Upon undergoing mucoid conversion within the lungs of cystic fibrosis patients, the pathogenic bacterium Pseudomonas aeruginosa synthesises copious quantities of the virulence factor and exopolysaccharide alginate. The enzyme guanosine diphosphate ma... Read More about Virtual screening, identification and in vitro validation of small molecule GDP-mannose dehydrogenase inhibitors †.

Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health (2023)
Journal Article
Qiu, Y., Guitian, J., Webster, J. P. P., Musallam, I., Haider, N., Drewe, J. A. A., & Song, J. (2023). Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health. Philosophical Transactions B: Biological Sciences, 378(1887), Article ARTN 20220407. https://doi.org/10.1098/rstb.2022.0407

Zoonotic diseases (zoonoses) originating from domestic animals pose a significant risk to people's health and livelihoods, in addition to jeopardizing animal health and production. Effective surveillance of endemic zoonoses at the animal level is cru... Read More about Global prioritization of endemic zoonotic diseases for conducting surveillance in domestic animals to protect public health.

Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection (2023)
Journal Article
Fraser-Pitt, D., Mercer, D. K., Francis, M., Toledo-Aparicio, D., Smith, D. W., & O'Neil, D. A. (2023). Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection. Biochemical and Biophysical Research Communications, 677, 168-181. https://doi.org/10.1016/j.bbrc.2023.08.021

Transient blockade of glycine decarboxylase (GLDC) can restrict de novo pyrimidine synthesis, which is a well-described strategy for enhancing the host interferon response to viral infection and a target pathway for some licenced anti-inflammatory th... Read More about Cysteamine-mediated blockade of the glycine cleavage system modulates epithelial cell inflammatory and innate immune responses to viral infection.