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All Outputs (102)

Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review (2023)
Journal Article
Nuwangi, H., Agampodi, T. C., Price, H. P., Shepherd, T., Weerakoon, K., & Agampodi, S. (in press). Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review. PLoS Neglected Tropical Diseases, 17(12), Article e0011818. https://doi.org/10.1371/journal.pntd.0011818

Background
Cutaneous (CL) and mucocutaneous leishmaniasis (MCL) are parasitic diseases caused by parasites of the genus leishmania leading to stigma caused by disfigurations. This study aimed to systematically review the dimensions, measurement meth... Read More about Stigma associated with cutaneous and mucocutaneous leishmaniasis: A systematic review.

The Role of Plant Latex in Virus Biology (2023)
Journal Article
Merchán-Gaitán, J. B., Mendes, J. H. L., Nunes, L. E. C., Buss, D. S., Rodrigues, S. P., & Fernandes, P. M. B. (in press). The Role of Plant Latex in Virus Biology. Viruses, 16(1), Article 47. https://doi.org/10.3390/v16010047

At least 20,000 plant species produce latex, a capacity that appears to have evolved independently on numerous occasions. With a few exceptions, latex is stored under pressure in specialized cells known as laticifers and is exuded upon injury, leadin... Read More about The Role of Plant Latex in Virus Biology.

Migratory birds are able to choose the appropriate migratory direction under dim yellow narrowband light (2023)
Journal Article
Romanova, N., Utvenko, G., Prokshina, A., Cellarius, F., Fedorishcheva, A., & Pakhomov, A. (2023). Migratory birds are able to choose the appropriate migratory direction under dim yellow narrowband light. Proceedings of the Royal Society B: Biological Sciences, 290(2013), https://doi.org/10.1098/rspb.2023.2499

Currently, it is generally assumed that migratory birds are oriented in the appropriate migratory direction under UV, blue and green light (short-wavelength) and are unable to use their magnetic compass in total darkness and under yellow and red ligh... Read More about Migratory birds are able to choose the appropriate migratory direction under dim yellow narrowband light.

Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs (2023)
Journal Article
Williams, H. M., Moeller, J. B., Burns, I., Schlosser, A., Sorensen, G. L., Greenhough, T. J., Holmskov, U., & Shrive, A. K. (2023). Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs. Journal of Biological Chemistry, 105552. https://doi.org/10.1016/j.jbc.2023.105552

Fibrinogen C-domain containing-1 (FIBCD1) is an immune protein proposed to be involved in host recognition of chitin on the surface of pathogens. As FIBCD1 readily binds to acetylated molecules, we have determined the high-resolution crystal structur... Read More about Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs.

Oscillating magnetic field does not disrupt orientation in the presence of stellar cues in an avian migrant (2023)
Journal Article
Bojarinova, J., Kavokin, K., Fedorishcheva, A., Sannikov, D., Cherbunin, R., Pakhomov, A., & Chernetsov, N. (2024). Oscillating magnetic field does not disrupt orientation in the presence of stellar cues in an avian migrant. Journal of Ornithology, 165(2), 347-354. https://doi.org/10.1007/s10336-023-02129-w

Weak oscillating magnetic fields (OMF) in the radiofrequency range are known to disrupt the orientation of birds. However, until now, it has not been experimentally verified that the sensitivity to OMF is a characteristic feature specifically of the... Read More about Oscillating magnetic field does not disrupt orientation in the presence of stellar cues in an avian migrant.

CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus (2023)
Journal Article
Harvey-Samuel, T., Feng, X., Okamoto, E. M., Purusothaman, D.-K., Leftwich, P. T., Alphey, L., & Gantz, V. M. (in press). CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus. Nature communications, 14(1), Article 7561. https://doi.org/10.1038/s41467-023-41834-1

Culex mosquitoes pose a significant public health threat as vectors for a variety of diseases including West Nile virus and lymphatic filariasis, and transmit pathogens threatening livestock, companion animals, and endangered birds. Rampant insectici... Read More about CRISPR-based gene drives generate super-Mendelian inheritance in the disease vector Culex quinquefasciatus.

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., Skidmore, M. A., Miller, G. J., & Cosgrove, S. C. (2023). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300752. https://doi.org/10.1002/cbic.202300625

Wahart et al. demonstrate the use of an immobilised oxidase enzyme coupled to an extractive amino resin for the bioremediation of a common industrial surfactant. This allows the facile purification of alkyl monoglucosides without the need for high en... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides.

Current sampling and sequencing biases of Lassa mammarenavirus limit inference from phylogeography and molecular epidemiology in Lassa fever endemic regions (2023)
Journal Article
Arruda, L. B., Free, H. B., Simons, D., Ansumana, R., Elton, L., Haider, N., Honeyborne, I., Asogun, D., McHugh, T. D., Ntoumi, F., Zumla, A., & Kock, R. (in press). Current sampling and sequencing biases of Lassa mammarenavirus limit inference from phylogeography and molecular epidemiology in Lassa fever endemic regions. PLOS Global Public Health, 3(11), Article e0002159. https://doi.org/10.1371/journal.pgph.0002159

Lassa fever (LF) is a potentially lethal viral haemorrhagic infection of humans caused by Lassa mammarenavirus (LASV). It is an important endemic zoonotic disease in West Africa with growing evidence for increasing frequency and sizes of outbreaks. P... Read More about Current sampling and sequencing biases of Lassa mammarenavirus limit inference from phylogeography and molecular epidemiology in Lassa fever endemic regions.

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. (2023)
Journal Article
Hoolachan, J. M., McCallion, E., Sutton, E. R., Çetin, Ö., Pacheco-Torres, P., Dimitriadi, M., Sari, S., Miller, G. J., Okoh, M., Walter, L. M., Claus, P., Wood, M. J., Tonge, D., & Bowerman, M. (2024). A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. Human molecular genetics, 33(5), 400–425. https://doi.org/10.1093/hmg/ddad192

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly slow down disease progres... Read More about A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models..

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. (2023)
Journal Article
Mogas Barcons, A., Chari, D. M., & Adams, C. (in press). In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. Alternatives to animal experimentation : a journal for new paths in biomedical science / edited by the Swiss Society ALTEX Edition, 41(2), 202-212. https://doi.org/10.14573/altex.2304171

Effective repair of spinal cord injury sites remains a major clinical challenge. One promising strategy is the implantation of multifunctional bioscaffolds to enhance nerve fibre growth, guide regenerating tissue and modulate scarring/inflammation pr... Read More about In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation..

Neighbours matter and the weak succumb: Ash dieback infection is more severe in ash trees with fewer conspecific neighbours and lower prior growth rate (2023)
Journal Article
J. Cracknell, D., F. Peterken, G., Pommerening, A., J. Lawrence, P., & R. Healey, J. (2023). Neighbours matter and the weak succumb: Ash dieback infection is more severe in ash trees with fewer conspecific neighbours and lower prior growth rate. Journal of Ecology, 111(10), 2118-2133. https://doi.org/10.1111/1365-2745.14191

The epidemiology and severity of ash dieback (ADB), the disease caused by the ascomycete fungus Hymenoscyphus fraxineus, has been linked to a variety of site conditions; however, there has been a lack of analysis at an individual tree scale.
Symptom... Read More about Neighbours matter and the weak succumb: Ash dieback infection is more severe in ash trees with fewer conspecific neighbours and lower prior growth rate.

Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment (2023)
Thesis
Ottih, E. C. Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment. (Thesis). Keele University. https://keele-repository.worktribe.com/output/598866

Genetic Mosquito mass release is a promising tool in the suppression of wild Anopheles gambiae sensu lato mosquitoes as part of malaria control in Africa. This tool requires a plethora number of eggs and a strain with good fitness. Thus, the success... Read More about Natural variations in egg hatching behaviour and selection of novel slowhatching strains for male anopheline deployment.

Shedding off-the-grid: The role of garment manufacturing and textile care in global microfibre pollution (2023)
Journal Article
Stanton, T., Stanes, E., Gwinnett, C., Lei, X., Cauilan-Cureg, M., Ramos, M., Sallach, J. B., Harrison, E., Osborne, A., Sanders, C. H., Baynes, E., Law, A., Johnson, M., Ryves, D. B., Sheridan, K. J., Blackburn, R. S., & McKay, D. (2023). Shedding off-the-grid: The role of garment manufacturing and textile care in global microfibre pollution. Journal of Cleaner Production, 428, Article 139391. https://doi.org/10.1016/j.jclepro.2023.139391

Textile fibres are abundant anthropogenic pollutants. These fibres enter aquatic, terrestrial, and atmospheric environments, and biota. Textile fibres pose biological and chemical threats to the environments they pollute. Laundry is a primary source... Read More about Shedding off-the-grid: The role of garment manufacturing and textile care in global microfibre pollution.

Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review (2023)
Journal Article
Watford, T., & Masood, N. (2023). Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review. Clinical Psychopharmacology and Neuroscience, 22(1), 2-12. https://doi.org/10.9758/cpn.23.1120

Psilocybin is a classical psychedelic which has been utilised for healing purposes for millenia. However, with its classification as a Schedule I substance, research into this compound is scarce with few FDA-approved clinical studies. Despite this, p... Read More about Psilocybin, an Effective Treatment for Major Depressive Disorder in Adults - A Systematic Review.

Isles and Islands (2023)
Book
McKay, D. (2023). Isles and Islands. British Council

Isles and islands features opportunities to enhance the growth of creative collaborations between the Philippines and the UK. These collaborations are not only a story of creativity, but a story of navigating bureaucracy. Making collaborations visibl... Read More about Isles and Islands.

The neglected spaces of economic rescaling: Insights into the in-between spaces of city-regionalism (2023)
Journal Article
Peacock, A., & Pemberton, S. (in press). The neglected spaces of economic rescaling: Insights into the in-between spaces of city-regionalism. Environment and Planning C: Politics and Space, https://doi.org/10.1177/23996544231207261

Over the last twenty years considerable attention has focused on the territorial restructuring and rescaling of the state. In particular, there has been an emphasis on city-regionalism to enhance the capacity of formal and more informal structures of... Read More about The neglected spaces of economic rescaling: Insights into the in-between spaces of city-regionalism.

Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. (2023)
Journal Article
Wahart, A. J. C., Dolan, J. P., Anderson, S. D., Cheallaigh, A. N., Staniland, J., Lima, M. A., Skidmore, M. A., Miller, G. J., & Cosgrove, S. C. (in press). Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides. ChemBioChem, Article e202300625. https://doi.org/10.1002/cbic.202300625

As the world moves towards net-zero carbon emissions, the development of sustainable chemical manufacturing processes is essential. Within manufacturing, purification by distillation is often used, however this process is energy intensive and methods... Read More about Harnessing a Biocatalyst to Bioremediate the Purification of Alkylglycosides..