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All Outputs (39)

Screening of an open-source compound library against the livestock parasite Trypanosoma evansi (2024)
Thesis
Ansah, M. L. K. (2024). Screening of an open-source compound library against the livestock parasite Trypanosoma evansi. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853242

Surra is a neglected tropical veterinary disease that causes a large socioeconomic burden in sub-Saharan Africa, South America, the middle east, Asia, and parts of Southern Europe. Although symptoms can be mild in wild animal species, disease in dome... Read More about Screening of an open-source compound library against the livestock parasite Trypanosoma evansi.

Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum (2024)
Thesis
Mobley, R. M. (2024). Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853179

Malaria continues to cause great global health concerns despite efforts for control and elimination. The emergence of resistance to components of the frontline artemisinin combination therapy highlights the urgent need for novel malaria therapeutics... Read More about Evaluating the antiplasmodial activity of synthetic and natural product libraries against intraerythrocytic Plasmodium falciparum.

Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems (2024)
Thesis
Nascimento, C. L. D. (2024). Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/853170

Vector-borne diseases are responsible for 17% of all infectious diseases worldwide and contribute to more than 700 000 deaths annually, mainly in sub-Saharan countries. Vector surveillance is a crucial element of vector control programmes to assure t... Read More about Evaluation of Nanopore sequencing for interrogating mosquito pools from surveillance systems.

Investigating multiple factors affecting the successful infection and transmission of arboviruses (2024)
Thesis
Widlake, E. (2024). Investigating multiple factors affecting the successful infection and transmission of arboviruses. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/850302

Arboviruses are arthropod-borne viruses that cycle between a vertebrate host and an arthropod vector. This disparate life cycle involves adapting to two alternate animals and the differing tissues and systems within them. A range of factors influence... Read More about Investigating multiple factors affecting the successful infection and transmission of arboviruses.

Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes (2024)
Journal Article
Traoré, N., Galizi, R., Kientega, M., Maïga, H., Nébié, K., Dabiré, R. A., …Diabaté, A. (in press). Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes. Journal of Applied Entomology, https://doi.org/10.1111/jen.13314

The Oriental fruit fly, Bactrocera dorsalis, is a pest of significant economic interest that damages horticulture and causes major economic losses worldwide. The main control measures are based on insecticides, which are being increasingly restricted... Read More about Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes.

International Biological Flora: Ceratonia siliqua (2024)
Journal Article
Thomas, P. A., Garcia‐Martí, X., Mukassabi, T. A., & Tous, J. (in press). International Biological Flora: Ceratonia siliqua. Journal of Ecology, https://doi.org/10.1111/1365-2745.14325

This account presents information on all aspects of the biology of Ceratonia siliqua L. (Carob) that are relevant to understanding its ecological characteristics and behaviour. The main topics are presented within the standard framework of the Intern... Read More about International Biological Flora: Ceratonia siliqua.

Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS (2024)
Journal Article
Piccinini, A., Kohlbrecher, J., Moussaoui, D., Winter, A., & Prévost, S. (in press). Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS. Journal of Colloid and Interface Science, 669, 844-855. https://doi.org/10.1016/j.jcis.2024.04.211

Lamellarity and shape are important factors in the formation of vesicles and determine their role in biological systems and pharmaceutical applications. Cardiolipin (CL) is a major lipid in many biological membranes and exerts a gr... Read More about Effect of cardiolipin on the lamellarity and elongation of liposomes hydrated in PBS.

Identifying archived insect bulk samples using DNA metabarcoding: A case study using the long‐term Rothamsted Insect Survey (2024)
Journal Article
Petsopoulos, D., Cuff, J. P., Bell, J. R., Kitson, J. J. N., Collins, L., Boonham, N., …Evans, D. M. (2024). Identifying archived insect bulk samples using DNA metabarcoding: A case study using the long‐term Rothamsted Insect Survey. Environmental DNA, 6(3), e542. https://doi.org/10.1002/edn3.542

Insect populations are declining in many parts of the world, but a lack of long-term monitoring data is impeding our ability to understand and mitigate the causes of insect biodiversity loss. Whilst high-throughput sequencing (HTS) approaches, such a... Read More about Identifying archived insect bulk samples using DNA metabarcoding: A case study using the long‐term Rothamsted Insect Survey.

DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS (2024)
Working Paper
Ansumana, R., Bockarie, A. S., Konneh, M., Haider, N., Cadmus, E., Korvah, A., …Alders, R. DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS

Background Outbreaks of infectious diseases like Ebola virus disease, Lassa fever, and COVID-19 have severely strained infrastructural systems and social services across West Africa. We investigated the disruptions caused by emerging outbreaks on acc... Read More about DISRUPTIONS IN LIVELIHOODS, HEALTHCARE ACCESS AND HEALTH OUTCOMES IN WEST AFRICA DURING EMERGING INFECTIOUS DISEASE OUTBREAKS.

Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso (2024)
Journal Article
Traoré, N., Kientega, M., Maïga, H., Nebié, K., Zida, I., Galizi, R., …Diabaté, A. (2024). Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso. Insects, 15(5), Article 298. https://doi.org/10.3390/insects15050298

Bactrocera dorsalis Hendel is a highly invasive horticultural pest that is of major economic importance worldwide. In Burkina Faso, it is one of the main insect pests that affects the production and exportation of mangos. Understanding the biology an... Read More about Genetic Diversity and Population Structure of the Invasive Oriental Fruit Fly, Bactrocera dorsalis (Diptera: Tephritidae) in Burkina Faso.

How aphids fly: take off, free flight and implications for short and long distance migration (2024)
Journal Article
Bell, J. R., & Shephard, G. (in press). How aphids fly: take off, free flight and implications for short and long distance migration. Agricultural and forest entomology, 1-10. https://doi.org/10.1111/afe.12623

An introduction to high‐speed photography and its entomological impact is provided, emphasizing the importance of high frame rates and high resolution. The take‐off and free flight of Drepanosiphum platanoidis and Myzus persicae were studied in still... Read More about How aphids fly: take off, free flight and implications for short and long distance migration.

444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee (2024)
Presentation / Conference
Tierney, L., Jones, A., McCarthy, H. S., Roberts, S., Tonge, D., & Wright, K. T. (2024, April). 444 Differential Transcriptome Signatures of Success are Identified within Different Cell Populations used for Treating Cartilage Defects in the Knee. Poster presented at 2024 OARSI World Congress on Osteoarthritis, Vienna, Austria

Defense strategies and associated phytohormonal regulation in Brassica plants in response to chewing and sap-sucking insects (2024)
Journal Article
Ali, J., Tonğa, A., Islam, T., Mir, S., Mukarram, M., Konôpková, A. S., & Chen, R. (in press). Defense strategies and associated phytohormonal regulation in Brassica plants in response to chewing and sap-sucking insects. Frontiers in Plant Science, 15, Article 1376917. https://doi.org/10.3389/fpls.2024.1376917

Plants have evolved distinct defense strategies in response to a diverse range of chewing and sucking insect herbivory. While chewing insect herbivores, exemplified by caterpillars and beetles, cause visible tissue damage and induce jasmonic acid (JA... Read More about Defense strategies and associated phytohormonal regulation in Brassica plants in response to chewing and sap-sucking insects.

Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein. (2024)
Journal Article
Baber, H., Aghajani, A., Gallimore, B. H., Bethel, C., Hyatt, J. G., King, E. F. B., …Winter, A. (2024). Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein. Biochimie, 223, 31-40. https://doi.org/10.1016/j.biochi.2024.03.017

Leishmaniasis is a spectrum of conditions caused by infection with the protozoan Leishmania spp. parasites. Leishmaniasis is endemic in 98 countries around the world, and resistance to current anti-leishmanial drugs is rising. Our work has identified... Read More about Galactokinase-like protein from Leishmania donovani: Biochemical and structural characterization of a recombinant protein..

Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa (2024)
Journal Article
Haga, I. R., Shih, B. B., Tore, G., Polo, N., Ribeca, P., Gombo-Ochir, D., …Beard, P. M. (in press). Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa. Viruses, 16(4), Article 557. https://doi.org/10.3390/v16040557

Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus of the Poxviridae family. LSDV is a rapidly emerging, high-consequence pathogen of cattle, recently spreading from Africa and the Middle East into Europe and Asia. We have... Read More about Sequencing and Analysis of Lumpy Skin Disease Virus Whole Genomes Reveals a New Viral Subgroup in West and Central Africa.

BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing. (2024)
Journal Article
Carlton, A. J., Jeng, J.-Y., Grandi, F. C., De Faveri, F., Amariutei, A. E., De Tomasi, L., …Marcotti, W. (2024). BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing. Cell Reports, 43(4), Article 114025. https://doi.org/10.1016/j.celrep.2024.114025

Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic density (... Read More about BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing..

Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes (2024)
Thesis
Tierney, L. J. (2024). Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/775433

Autologous chondrocyte implantation (ACI) has repeatedly been shown to be an effective treatment for cartilage defects within the knee and can delay or prevent the need for a total knee replacement. However, the level of clinical benefit experienced... Read More about Cell therapy to treat knee cartilage defects - transcriptome exploration of autologous mesenchymal stromal cells and chondrocytes.

Dual stressors of infection and warming can destabilize host microbiomes (2024)
Journal Article
Li, J., Gao, Y., Stevens, E., & King, K. (2024). Dual stressors of infection and warming can destabilize host microbiomes. Philosophical Transactions B: Biological Sciences, 379(1901), https://doi.org/10.1098/rstb.2023.0069

Climate change is causing extreme heating events and intensifying infectious disease outbreaks. Animals harbour microbial communities, which are vital for their survival and fitness under stressful conditions. Understanding how microbiome structures... Read More about Dual stressors of infection and warming can destabilize host microbiomes.

Constraints and solutions for development and uptake of integrated pest management in the UK (2024)
Journal Article
Walters, K. F. A., Parry, G., Burnstone, J., Grenz, K., Collier, R., & Bruce, T. (in press). Constraints and solutions for development and uptake of integrated pest management in the UK. Annals of Applied Biology, https://doi.org/10.1111/aab.12896

Agricultural improvements that reduce conventional pesticide use and support environmental aims are a priority. Current approaches develop promising alternative products but meet significant challenges in bringing them to market. This article reports... Read More about Constraints and solutions for development and uptake of integrated pest management in the UK.