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Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research (2023)
Thesis
Ranjbar, J. A. (2023). Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research. (Thesis). Keele University. Retrieved from https://keele-repository.worktribe.com/output/674551

Intravital microscopy in mice is widely used to study in vivo thrombus formation, however, the relevance of these studies to human physiology is unclear. In this thesis, a 3D tissue-engineered human arterial construct (TEAC) was developed that replic... Read More about Recreating arterial thrombosis models using tissue-engineered arterial constructs: A method to reduce and replace mice used in platelet research.

A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia (2022)
Thesis
Chacko, S. M. (2022). A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia. (Thesis). Keele University

Introduction: Acute myocardial ischaemia and the transition from reversible to irreversible myocardial injury are associated with abnormal metabolic patterns. Advances in metabolomics have extended our capabilities to define these metabolic perturbat... Read More about A metabolomic analysis of cardiac metabolism in a human model of early myocardial ischaemia.

Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.