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Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka. (2021)
Journal Article
(2021). Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka. Behavior Genetics, https://doi.org/10.1007/s10519-021-10051-1

Anxiety not only concerns mental wellbeing but also negatively impacts other areas of health. Yet, there is limited research on (a) the genetic and environmental aetiology of such relationships; (b) sex differences in aetiology and (c) non-European s... Read More about Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka..

Mesenchymal stromal cell products for intra-articular knee injections for conservative management of osteoarthritis. (2021)
Journal Article
(2021). Mesenchymal stromal cell products for intra-articular knee injections for conservative management of osteoarthritis. Therapeutic Advances in Infectious Disease, 1759720X21996953 - ?. https://doi.org/10.1177/1759720X21996953

Sports injuries and secondary joint problems, mainly of the knee, are common, especially in sports associated with high impact activities and/or torsional loading. The consequences can be career ending in elite athletes and reduce exercise activities... Read More about Mesenchymal stromal cell products for intra-articular knee injections for conservative management of osteoarthritis..

Umbilical cord-derived Wharton's jelly for treatment of knee osteoarthritis: study protocol for a non-randomized, open-label, multi-center trial (2021)
Journal Article
(2021). Umbilical cord-derived Wharton's jelly for treatment of knee osteoarthritis: study protocol for a non-randomized, open-label, multi-center trial. Journal of Orthopaedic Surgery and Research, 143 - ?. https://doi.org/10.1186/s13018-021-02300-0

BACKGROUND: Osteoarthritis (OA) is the most common joint disorder in the USA, and knee OA has the highest prevalence. Inflammation and decrease in vascularization are key factors in the degeneration of articular cartilage and the associated pain and... Read More about Umbilical cord-derived Wharton's jelly for treatment of knee osteoarthritis: study protocol for a non-randomized, open-label, multi-center trial.

Using Google Trends to assess the impact of Global Public Health Days on online health information-seeking behaviour in Arabian Peninsula (2021)
Journal Article
Ajbar, A., Shepherd, T. A., Robinson, M., Mallen, C. D., & Prior, J. A. (2021). Using Google Trends to assess the impact of Global Public Health Days on online health information-seeking behaviour in Arabian Peninsula. Journal of Egyptian Public Health Association, 94, Article 4. https://doi.org/10.1186/s42506-020-00063-w

BACKGROUND: Global Public Health Days (GPHD) are public health interventions which serve to improve public awareness of specific health conditions. Google Trends is a publicly available tool that allows the user to view the popularity of a searched k... Read More about Using Google Trends to assess the impact of Global Public Health Days on online health information-seeking behaviour in Arabian Peninsula.

Misdiagnosis of Acute Myocardial Infarction: A Systematic Review of the Literature (2021)
Journal Article
Kwok, C. S., Bennett, S., Azam, Z., Welsh, V., Potluri, R., Loke, Y. K., & Mallen, C. D. (2021). Misdiagnosis of Acute Myocardial Infarction: A Systematic Review of the Literature. Critical Pathways in Cardiology: A Journal of Evidence-Based Medicine, 20(3), 155-162. https://doi.org/10.1097/HPC.0000000000000256

Background: Despite the availability of tests to diagnose acute myocardial infarction (AMI), cases are still missed. Methods: We systematically reviewed the literature to determine how missed AMI has been defined, the reported rates of misdiagnosed A... Read More about Misdiagnosis of Acute Myocardial Infarction: A Systematic Review of the Literature.

Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies (2021)
Journal Article
Huang, X., Wilkie, R., Mamas, M., & Yu, D. (2021). Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies. MedRxiv, https://doi.org/10.1101/2021.02.14.21251130v1

Background People with osteoarthritis are at a high risk of cardiovascular disease (CVD). Detecting CVD risk factors in this high-risk population will help to improve CVD outcomes. Primary care electronic health records (EHRs) provide opportunities f... Read More about Prevalence of cardiovascular risk factors in osteoarthritis patients derived from primary care records: a systematic review of observational studies.

Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). (2021)
Journal Article
Mamas, Sykes, R., Mohamed, M. O., Kwok, C. S., Mamas, M. A., & Berry, C. (2021). Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database). Clinical Cardiology, 44(3), 291 - 306. https://doi.org/10.1002/clc.23543

Percutaneous coronary intervention (PCI) improves anginal chest pain in most, but not all, treated patients. PCI is associated with unplanned readmission for angina and non-specific chest pain within 30-days of index PCI. Patients with an index hospi... Read More about Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (Nationwide Readmissions Database)..

Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020 (2021)
Journal Article
Wu, J., Mafham, M., Mamas, M. A., Rashid, M., Kontopantelis, E., Dean, J. E., …Gale, C. P. (2021). Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020. Mayo Clinic Proceedings, 96(4), 952 - 963. https://doi.org/10.1016/j.mayocp.2021.02.007

OBJECTIVE: To describe the place and cause of death during the coronavirus disease 2019 (COVID-19) pandemic to assess its impact on excess mortality. METHODS: This national death registry included all adult (aged =18 years) deaths in England and... Read More about Place and Underlying Cause of Death During the COVID-19 Pandemic: Retrospective Cohort Study of 3.5 Million Deaths in England and Wales, 2014 to 2020.

Identification of Radiographic Foot Osteoarthritis: Sensitivity of Views and Features Using the La Trobe Radiographic Atlas (2021)
Journal Article
Menz, H. B., Munteanu, S. E., Marshall, M., Thomas, M. J., Rathod‐Mistry, T., Peat, G. M., & Roddy, E. (2022). Identification of Radiographic Foot Osteoarthritis: Sensitivity of Views and Features Using the La Trobe Radiographic Atlas. Arthritis Care & Research, 74(8), 1369-1373. https://doi.org/10.1002/acr.24582

ObjectiveTo compare the sensitivity of alternative case finding approaches for the identification of foot osteoarthritis (OA) based on the La Trobe radiographic atlas.MethodsThis was a cross‐sectional study of 533 adults age ≥50 years with foot pain... Read More about Identification of Radiographic Foot Osteoarthritis: Sensitivity of Views and Features Using the La Trobe Radiographic Atlas.

Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. (2021)
Journal Article
Mamas. (2021). Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction. https://doi.org/10.1016/j.amjcard.2020.11.016

Transradial access (TRA) has emerged as an alternative to transfemoral access (TFA) for percutaneous coronary intervention (PCI) in ST elevation myocardial infarction (STEMI) patients. However, the rate of TRA adoption has been much slower in the acu... Read More about Meta-Analysis of Transradial vs Transfemoral Access for Percutaneous Coronary Intervention in Patients With ST Elevation Myocardial Infarction..

GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting (2021)
Journal Article
Coates, L. C., Corp, N., Van Der Windt, D. A., Soriano, E. R., & Kavanaugh, A. (2021). GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting. Journal of Rheumatology, https://doi.org/10.3899/jrheum.201681

Throughout 2020, the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) has been working to update the GRAPPA treatment recommendations for psoriasis and psoriatic arthritis (PsA). The planned methodology for this update... Read More about GRAPPA Treatment Recommendations: An Update From the 2020 GRAPPA Annual Meeting.

Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial (2021)
Journal Article
Law, Z. K., Desborough, M., Roberts, I., Al‐Shahi Salman, R., England, T. J., Werring, D. J., …Sprigg, N. (2021). Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial. Journal of the American Heart Association, 10(5), https://doi.org/10.1161/jaha.120.019130

BackgroundAntiplatelet therapy increases the risk of hematoma expansion in intracerebral hemorrhage (ICH) while the effect on functional outcome is uncertain.Methods and ResultsThis is an exploratory analysis of the TICH‐2 (Tranexamic Acid in Intrace... Read More about Outcomes in Antiplatelet‐Associated Intracerebral Hemorrhage in the TICH‐2 Randomized Controlled Trial.

Community-based complex interventions to sustain independence in older people, stratified by frailty: a protocol for a systematic review and network meta-analysis (2021)
Journal Article
Crocker, T. F., Clegg, A., Riley, R. D., Lam, N., Bajpai, R., Jordão, M., …Gladman, J. R. F. (2021). Community-based complex interventions to sustain independence in older people, stratified by frailty: a protocol for a systematic review and network meta-analysis. BMJ Open, 11(2), Article ARTN e045637. https://doi.org/10.1136/bmjopen-2020-045637

INTRODUCTION: Maintaining independence is a primary goal of community health and care services for older people, but there is currently insufficient guidance about which services to implement. Therefore, we aim to synthesise evidence on the effective... Read More about Community-based complex interventions to sustain independence in older people, stratified by frailty: a protocol for a systematic review and network meta-analysis.

External validation of clinical prediction models: simulation-based sample size calculations were more reliable than rules-of-thumb. (2021)
Journal Article
(2021). External validation of clinical prediction models: simulation-based sample size calculations were more reliable than rules-of-thumb. Journal of Clinical Epidemiology, https://doi.org/10.1016/j.jclinepi.2021.02.011

INTRODUCTION: Sample size 'rules-of-thumb' for external validation of clinical prediction models suggest at least 100 events and 100 non-events. Such blanket guidance is imprecise, and not specific to the model or validation setting. We investigate f... Read More about External validation of clinical prediction models: simulation-based sample size calculations were more reliable than rules-of-thumb..

Management of Patellar Chondral Defects with Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures: A Four Years Follow-Up Clinical Trial. (2021)
Journal Article
(2021). Management of Patellar Chondral Defects with Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures: A Four Years Follow-Up Clinical Trial. Life, https://doi.org/10.3390/life11020141

INTRODUCTION: Evidence on the management of chondral defects of the patella arises from studies in which the patellofemoral joint was treated together with the femorotibial joint and primary and revision settings. Furthermore, the superiority of Auto... Read More about Management of Patellar Chondral Defects with Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures: A Four Years Follow-Up Clinical Trial..

Diagnostic criteria for early hip osteoarthritis; first steps, based on the CHECK study. (2021)
Journal Article
(2021). Diagnostic criteria for early hip osteoarthritis; first steps, based on the CHECK study. Rheumatology, https://doi.org/10.1093/rheumatology/keab111

OBJECTIVES: Although there is a general focus on early diagnosis and treatment of hip osteoarthritis, there are no validated diagnostic criteria for early-stage hip OA. The current study aimed to take the first steps in developing diagnostic criteria... Read More about Diagnostic criteria for early hip osteoarthritis; first steps, based on the CHECK study..

Shoe-stiffening inserts for first metatarsophalangeal joint osteoarthritis: a randomised trial. (2021)
Journal Article
Munteanu, S., Landorf, K., McClelland, J., Roddy, E., Cicuttini, F., Shiell, A., …Menz, H. (2021). Shoe-stiffening inserts for first metatarsophalangeal joint osteoarthritis: a randomised trial. Osteoarthritis and Cartilage, 480-490. https://doi.org/10.1016/j.joca.2021.02.002

OBJECTIVE: To evaluate the efficacy of carbon-fibre shoe-stiffening inserts in individuals with first metatarsophalangeal joint osteoarthritis. DESIGN: This was a randomised, sham-controlled, participant- and assessor-blinded trial. One hundred p... Read More about Shoe-stiffening inserts for first metatarsophalangeal joint osteoarthritis: a randomised trial..

The influence of candidates' physical attributes on assessors' ratings in clinical practice (2021)
Journal Article
Sam, A., Reid, M., Thakerar, V., Gurnell, M., Westacott, R., Yeates, P., …Brown, C. (2021). The influence of candidates' physical attributes on assessors' ratings in clinical practice. Medical Teacher, 43(5), 554-559. https://doi.org/10.1080/0142159X.2021.1877268

BACKGROUND: Assessments of physician competence in the work-place are common and often contribute to high-stakes assessments. Previous research suggests that assessors' judgements can be influenced by candidates' physical attributes. We investigated... Read More about The influence of candidates' physical attributes on assessors' ratings in clinical practice.

Excess mortality in England and Wales during the first wave of the COVID-19 pandemic (2021)
Journal Article
Mamas. (2021). Excess mortality in England and Wales during the first wave of the COVID-19 pandemic. Journal of epidemiology and community health, 213-223. https://doi.org/10.1136/jech-2020-214764

Background Deaths during the COVID-19 pandemic result directly from infection and exacerbation of other diseases and indirectly from deferment of care for other conditions, and are socially and geographically patterned. We quantified excess mortality... Read More about Excess mortality in England and Wales during the first wave of the COVID-19 pandemic.