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ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention. (2021)
Journal Article
Davies, & Lambie. (2021). ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention. Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 352-372. https://doi.org/10.1177/0896860820982218

GUIDELINE 1: A pathophysiological taxonomy: A pathophysiological classification of membrane dysfunction, which provides mechanistic links to functional characteristics, should be used when prescribing individualized dialysis or when planning modality... Read More about ISPD recommendations for the evaluation of peritoneal membrane dysfunction in adults: Classification, measurement, interpretation and rationale for intervention..

"People play it down and tell me it can't kill people, but I know people are dying each day". Children's health literacy relating to a global pandemic (COVID-19); an international cross sectional study. (2021)
Journal Article
Protheroe. (2021). "People play it down and tell me it can't kill people, but I know people are dying each day". Children's health literacy relating to a global pandemic (COVID-19); an international cross sectional study. PloS one, e0246405 - ?. https://doi.org/10.1371/journal.pone.0246405

The aim of this study was to examine aspects of children's health literacy; the information sources they were accessing, their information preferences, their perceived understanding of and their reported information needs in relation to COVID-19. An... Read More about "People play it down and tell me it can't kill people, but I know people are dying each day". Children's health literacy relating to a global pandemic (COVID-19); an international cross sectional study..

Association between antihypertensive treatment and adverse events: systematic review and meta-analysis (2021)
Journal Article
Albasri, A., Hattle, M., Koshiaris, C., Dunnigan, A., Paxton, B., Emma Fox, S., …Sheppard, J. P. (2021). Association between antihypertensive treatment and adverse events: systematic review and meta-analysis. BMJ, 372, https://doi.org/10.1136/bmj.n189

OBJECTIVE: To examine the association between antihypertensive treatment and specific adverse events. DESIGN: Systematic review and meta-analysis. ELIGIBILITY CRITERIA: Randomised controlled trials of adults receiving antihypertensives compare... Read More about Association between antihypertensive treatment and adverse events: systematic review and meta-analysis.

Estimating the population health burden of musculoskeletal conditions using primary care electronic health records (2021)
Journal Article
Yu, D., Peat, G., Jordan, K., Bailey, J., Prieto-Alhambra, D., Robinson, D., …Wilkie, R. (2021). Estimating the population health burden of musculoskeletal conditions using primary care electronic health records. Rheumatology, 60(10), 4832-4843. https://doi.org/10.1093/rheumatology/keab109

Objectives Better indicators from affordable, sustainable data sources are needed to monitor population burden of musculoskeletal conditions. We propose five indicators of musculoskeletal health and assessed if routinely available primary care elect... Read More about Estimating the population health burden of musculoskeletal conditions using primary care electronic health records.

Prevalence and associated factors of DSM-5 insomnia disorder in the general population of Qatar (2021)
Journal Article
Khaled, S. M., Petcu, C., Al-Thani, M. A., Al-Hamadi, A. M. H. A., Daher-Nashif, S., Zolezzi, M., & Woodruff, P. (2021). Prevalence and associated factors of DSM-5 insomnia disorder in the general population of Qatar. BMC Psychiatry, 21(1), https://doi.org/10.1186/s12888-020-03035-8

Background Epidemiological studies of insomnia in the Middle East remain scarce. The present study aimed to estimate the prevalence of insomnia and explore its associations in the general population of Qatar. With almost 100 nationalities, Qatar is... Read More about Prevalence and associated factors of DSM-5 insomnia disorder in the general population of Qatar.

Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. (2021)
Journal Article
Kinnaird, T., Anderson, R., Gallagher, S., Sharp, A. S. P., Farooq, V., Ludman, P., …Mamas, M. (2021). Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database. Catheterization and Cardiovascular Interventions, 98(1), E53-E61. https://doi.org/10.1002/ccd.29549

INTRODUCTION: The impact of a vascular complication (VC) in the setting of intraaortic balloon pump (IABP) supported PCI on clinical outcomes is unclear. METHODS: Using data from the BCIS National PCI Database, multivariate logistic regression was us... Read More about Vascular complications associated with intraaortic balloon pump supported percutaneous coronary intervention (PCI) and clinical outcomes from the British Cardiovascular Intervention Society National PCI Database..

The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. (2021)
Journal Article
Mamas. (2021). The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial. European Heart Journal, 684-696. https://doi.org/10.1093/eurheartj/ehaa758

Importance: Cardiovascular accumulation of collagen (fibrosis) may contribute to the progression from ventricular dysfunction to heart failure. Galectin-3, a potential marker of pro-fibrotic activity, might identify those at greater risk. Objective:... Read More about The Effect of Spironolactone on Cardiovascular Function and Markers of Fibrosis in People at Increased Risk of Developing Heart Failure: The Heart “OMics” in AGEing (HOMAGE) Randomised Clinical Trial..

Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis (2021)
Journal Article
Mamas. (2021). Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis. European Heart Journal: Acute Cardiovascular Care, 829-839. https://doi.org/10.1093/ehjacc/zuaa032

Aims Primary percutaneous coronary intervention (pPCI) is the gold standard, guideline-recommended revascularization strategy in patients presenting with ST-elevation myocardial infarction (STEMI). However, there are limited data on its use and effe... Read More about Effect of primary percutaneous coronary intervention on in-hospital outcomes among active cancer patients presenting with ST-elevation myocardial infarction: a propensity score matching analysis.

The FAST‐M complex intervention for the detection and management of maternal sepsis in low‐resource settings: a multi‐site evaluation (2021)
Journal Article
Cheshire, J., Jones, L., Munthali, L., Kamphinga, C., Liyaya, H., Phiri, T., …Lissauer, D. (2021). The FAST‐M complex intervention for the detection and management of maternal sepsis in low‐resource settings: a multi‐site evaluation. BJOG: An International Journal of Obstetrics and Gynaecology, 128(8), 1324–1333. https://doi.org/10.1111/1471-0528.16658

Objective To evaluate whether the implementation of the FAST-M complex intervention was feasible and improved the recognition and management of maternal sepsis in a low-resource setting. Design A before-and-after design. Setting Fifteen gove... Read More about The FAST‐M complex intervention for the detection and management of maternal sepsis in low‐resource settings: a multi‐site evaluation.

Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting (2021)
Journal Article
Mamas. (2021). Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting. International Journal of Clinical Practice, https://doi.org/10.1111/ijcp.14067

Background: Data on the incidence and outcomes of ischemic stroke in patients undergoing coronary artery bypass grafting (CABG) in the current era is limited. The goal of this study was to examine contemporary trends, predictors, and outcomes of isch... Read More about Incidence and Predictors of Postoperative Ischemic Stroke after Coronary Artery Bypass Grafting.

Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back! (2021)
Journal Article
Lewis, M., Bromley, K., Sutton, C., McCray, G., Myers, H., & Lancaster, G. (2021). Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!. Pilot and Feasibility Studies, 7, Article 40. https://doi.org/10.1186/s40814-021-00770-x

BACKGROUND: The current CONSORT guidelines for reporting pilot trials do not recommend hypothesis testing of clinical outcomes on the basis that a pilot trial is under-powered to detect such differences and this is the aim of the main trial. It state... Read More about Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!.

Survey of young people in one region of the UK on accessing COVID-19 information (SOCIAL) (2021)
Journal Article
Lawton, O. G., Lawton, S. A., Dikomitis, L., Protheroe, J., Smith, J., & Mallen, C. (2021). Survey of young people in one region of the UK on accessing COVID-19 information (SOCIAL). BMJ Paediatrics Open, e000942 - e000942. https://doi.org/10.1136/bmjpo-2020-000942

COVID-19 has significantly impacted young people’s lives yet little is known about the COVID-19 related sources of information they access. We performed a cross-sectional survey of pupils (11–16 years) in North Staffordshire, UK. 408 (23%) pupils res... Read More about Survey of young people in one region of the UK on accessing COVID-19 information (SOCIAL).

Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure (2021)
Journal Article
Mamas. (2021). Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure. International Journal of Cardiology, 205-213. https://doi.org/10.1016/j.ijcard.2020.09.076

Background – Atrial fibrillation (AF) and heart failure (HF) carry a poor prognosis in acute ischaemic stroke (AIS). The impact of revascularisation therapies on outcomes in these patients is not fully understood. Methods –National Inpatient Samp... Read More about Revascularisation Therapies Improve the Outcomes of Ischemic Stroke Patients with Atrial Fibrillation and Heart Failure.

Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy (2021)
Journal Article
Mamas, Clarson, Roddy, Mallen, & Helliwell. (2021). Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy. Mayo Clinic Proceedings, 388-399. https://doi.org/10.1016/j.mayocp.2020.04.044

Objectives: The present study sought to examine national-level differences in management strategies and outcomes in patients with autoimmune rheumatic disease (AIRD) with acute myocardial infarction (AMI) between 2004 and 2014. Methods: All AMI hos... Read More about Acute Myocardial Infarction in Autoimmune Rheumatological Disease: A Nationwide Analysis of Clinical outcomes and Predictors of Management Strategy.

Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis (2021)
Journal Article
Mamas, & Rashid. (2021). Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis. Mayo Clinic Proceedings, 363-376. https://doi.org/10.1016/j.mayocp.2020.04.045

Objective: We sought to investigate the clinical and procedural characteristics in patients with a history of Renal Transplant (RT) and compare the outcomes with non-RT patients in two national cohorts of patients undergoing percutaneous coronary int... Read More about Outcomes following Percutaneous Coronary Intervention in Renal Transplant Recipients; A Binational collaborative analysis.

Family-based Interventions Benefit Individuals with Musculoskeletal Pain in the Short-term but not in the Long Term: A Systematic Review and Meta-analysis. (2021)
Journal Article
Fritsch, C., Ferreira, M., da Silva, A., Simic, M., Dunn, K., Campbell, P., …Ferreira, P. (2021). Family-based Interventions Benefit Individuals with Musculoskeletal Pain in the Short-term but not in the Long Term: A Systematic Review and Meta-analysis. Clinical Journal of Pain, 37(2), 140-157. https://doi.org/10.1097/AJP.0000000000000897

INTRODUCTION: The benefits of family-based interventions for patients with musculoskeletal pain have been previously shown in individual randomised controlled trials (RCTs), but no systematic review has summarised their effects. MATERIALS AND METHODS... Read More about Family-based Interventions Benefit Individuals with Musculoskeletal Pain in the Short-term but not in the Long Term: A Systematic Review and Meta-analysis..

In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras (2021)
Journal Article
Mamas, M., & Rashid, M. (2021). In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras. Journal of Invasive Cardiology,

BACKGROUND: Public reporting of percutaneous coronary intervention (PCI) outcomes is a performance metric and a requirement in many healthcare systems. There are inconsistent data on the causes of death after PCI, and the proportion of these deaths t... Read More about In-Hospital and 30-Day Mortality After Percutaneous Coronary Intervention in England in the Pre-COVID and COVID Eras.

Rheumatic Conditions as Risk Factors for Self-Harm: A Retrospective Cohort Study (2021)
Journal Article
Prior, J. A., Paskins, Z., Whittle, R., Abdul-Sultan, A., Chew-Graham, C. A., Muller, S., …Mallen, C. D. (2021). Rheumatic Conditions as Risk Factors for Self-Harm: A Retrospective Cohort Study. Arthritis Care and Research, 73(1), 130-137. https://doi.org/10.1002/acr.24345

Objective To examine the risk of self-harm in rheumatological conditions Methods Retrospective cohort study using data from the Clinical Practice Research Datalink. Patients with ankylosing spondylitis, fibromyalgia, osteoarthritis or rheumatoid arth... Read More about Rheumatic Conditions as Risk Factors for Self-Harm: A Retrospective Cohort Study.