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Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort [version 1; peer review: 1 approved with reservations] (2023)
Journal Article
Maher, G. M., Kenny, L. C., Navaratnam, K., Alfirevic, Z., Sheehan, D., Baker, P. N., …Khashan, A. S. (2023). Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort [version 1; peer review: 1 approved with reservations]. HRB Open Research, 6(65), https://doi.org/10.12688/hrbopenres.13812.1

Background Improved Pregnancy Outcomes via Early Detection (IMPROvED) is a multi-centre, European phase IIa clinical study. The primary aim of IMPROvED is to enable the assessment and refinement of innovative prototype preeclampsia risk assessment t... Read More about Cohort profile: Improved Pregnancy Outcomes via Early Detection (IMPROvED), an International Multicentre Prospective Cohort [version 1; peer review: 1 approved with reservations].

A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina. (2023)
Journal Article
Rajkumar, C. A., Foley, M. J., Ahmed-Jushuf, F., Nowbar, A. N., Simader, F. A., Davies, J. R., …Al-Lamee, R. K. (in press). A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina. New England Journal of Medicine, https://doi.org/10.1056/NEJMoa2310610

Percutaneous coronary intervention (PCI) is frequently performed to reduce the symptoms of stable angina. Whether PCI relieves angina more than a placebo procedure in patients who are not receiving antianginal medication remains unknown. We conducted... Read More about A Placebo-Controlled Trial of Percutaneous Coronary Intervention for Stable Angina..

Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study (2023)
Journal Article
Mason, K. J., Alabas, O. A., Dand, N., Warren, R. B., Reynolds, N. J., Barker, J. N. W. N., …Warren, R. (2024). Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study. British Journal of Dermatology, 190(3), 441–444. https://doi.org/10.1093/bjd/ljad446

It is unknown why some psoriasis patients experience long-term effectiveness with their first biologic monotherapy. Our aim was to compare the baseline demographic, disease, genotypic, clinical and lifestyle characteristics of patients with psoriasis... Read More about Characteristics of ‘super responders’ and ‘super nonresponders’ to first biologic monotherapy for psoriasis: a nested case–control study.

Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy (2023)
Journal Article
Bentick, K., Runevic, J., Akula, S., Kyriacou, T., Cool, P., & Andras, P. (2023). Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy. Methods, 220, 55-60. https://doi.org/10.1016/j.ymeth.2023.10.012

This study explores the possibility of using routinely taken blood tests in the diagnosis and triage of patients with suspected musculoskeletal malignancy. A retrospective study was performed on results of patients who had presented for assessment to... Read More about Machine learning models based on routinely sampled blood tests can predict the presence of malignancy amongst patients with suspected musculoskeletal malignancy.

Risk of myocardial infarction following capecitabine treatment in patients with gastrointestinal cancer - a nationwide registry-based study (2023)
Journal Article
Shanmuganathan, J., Kragholm, K. H., Schou, M., Torp-Pedersen, C., Ostergaard Poulsen, L., Pareek, M., …Freeman, P. (2023). Risk of myocardial infarction following capecitabine treatment in patients with gastrointestinal cancer - a nationwide registry-based study. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.1208

Background Myocardial infarction is a cardiac adverse event associated with fluoropyrimidines such as 5-fluorouracil and its orally available prodrug capecitabine. There are limited data on the incidence, risk, and prognosis of capecitabine associate... Read More about Risk of myocardial infarction following capecitabine treatment in patients with gastrointestinal cancer - a nationwide registry-based study.

Sex specific lifetime risk of incident cardiovascular events. Results from a large British population-based cohort study (2023)
Journal Article
Pana, T. A., Mamas, M. A., Wareham, N. J., Khaw, K. T., Dawson, D. K., & Myint, P. K. (2023). Sex specific lifetime risk of incident cardiovascular events. Results from a large British population-based cohort study. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2375

Background There are marked sex differences in cardiovascular (CV) disease, most characteristically with men having a higher risk of coronary heart disease and myocardial infarction (MI). The sex differences in the absolute lifetime risk of CV diseas... Read More about Sex specific lifetime risk of incident cardiovascular events. Results from a large British population-based cohort study.

Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among complex patient groups (2023)
Journal Article
Mohamed, M., Kinnaird, T., Wijeysundera, H. C., Johnson, T. W., Zaman, S., Moledina, S., & Mamas, M. (2023). Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among complex patient groups. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2112

Background Intracoronary imaging (ICI) has been previously shown to improve survival and clinical outcomes after percutaneous coronary intervention (PCI). However, whether this prognostic benefit is sustained across different indications/patient grou... Read More about Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among complex patient groups.

Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among patients with cardiogenic shock (2023)
Journal Article
Mohamed, M., Kinnaird, T., Rab, T., Zaman, S., Banerjee, A., Sirker, A., …Mamas, M. (2023). Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among patients with cardiogenic shock. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2111

Background Intracoronary imaging (ICI), including intravascular ultrasound (IVUS) or optical coherence tomography (OCT), is known to correlate with a reduction in rates of cardiac death after percutaneous coronary intervention (PCI), driven by lower... Read More about Impact of intracoronary imaging-guided percutaneous coronary intervention on procedural outcomes among patients with cardiogenic shock.

Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study (2023)
Journal Article
Moledina, S., Weight, N., Dafaalla, M., Chen, D., Rashid, M., Mohamed, M., …Mamas, M. (2023). Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study. European Heart Journal, 44(Supplement_2), Article ehad655.3027. https://doi.org/10.1093/eurheartj/ehad655.3027

Background Contemporary studies have demonstrated that in non-ST-segment elevation myocardial infarction (NSTEMI), processes of care vary significantly according to biological sex. Little is known regarding variation in practice between geographical... Read More about Sex-based analysis of NSTEMI processes of care and outcomes by hospital: a nationwide cohort study.

Cardiovascular events following vascular endothelial growth factor inhibitor therapy with sunitinib or pazopanib in patients with renal cell carcinoma - a nationwide registry-based follow-up study (2023)
Journal Article
Shanmuganathan, J., Schou, M., Haider Butt, J., Torp-Pedersen, C., Ostergaard Poulsen, L., Pareek, M., …Kragholm, K. H. (2023). Cardiovascular events following vascular endothelial growth factor inhibitor therapy with sunitinib or pazopanib in patients with renal cell carcinoma - a nationwide registry-based follow-up study. European Heart Journal, 44(Supplement_2), https://doi.org/10.1093/eurheartj/ehad655.2699

Background Use of oral vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors (TKIs) with focus on sunitinib and pazopanib approved for treatment of patients with renal cell carcinoma (RCC) may be associated with cardiovascula... Read More about Cardiovascular events following vascular endothelial growth factor inhibitor therapy with sunitinib or pazopanib in patients with renal cell carcinoma - a nationwide registry-based follow-up study.

A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. (2023)
Journal Article
Hoolachan, J. M., McCallion, E., Sutton, E. R., Çetin, Ö., Pacheco-Torres, P., Dimitriadi, M., …Bowerman, M. (2023). A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models. Human molecular genetics, ddad192. https://doi.org/10.1093/hmg/ddad192

Spinal muscular atrophy (SMA) is a genetic neuromuscular disorder caused by the reduction of survival of motor neuron (SMN) protein levels. Although three SMN-augmentation therapies are clinically approved that significantly slow down disease progres... Read More about A transcriptomics-based drug repositioning approach to identify drugs with similar activities for the treatment of muscle pathologies in spinal muscular atrophy (SMA) models..

Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample (2023)
Journal Article
Rivera, F. B., Redula, S., Liston, M. B., Ong, E., Bantayan, N. R., Choi, S., …Mamas, M. (2023). Abstract 14815: Sex Differences in Transcatheter Aortic Valve Replacement Outcomes Among Patients With Bicuspid Aortic Stenosis: Insights From the National In-Patient Sample. Circulation, 148(Suppl_1), https://doi.org/10.1161/circ.148.suppl_1.14815

Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis. (2023)
Journal Article
Shahid, M., Ibrahim, R., Arakelyan, A., Hassan, K., Sainbayar, E., Pham, H. N., & Mamas, M. A. (in press). Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis. International Journal of Cardiology Cardiovascular Risk and Prevention, 19, Article 200224. https://doi.org/10.1016/j.ijcrp.2023.200224

Social vulnerability index (SVI) plays a pivotal role in the outcomes of cardiovascular diseases and prevalence of alcohol use. We evaluated the impact of the SVI on alcoholic cardiomyopathy (ACM) mortality. Mortality data from 1999 to 2020 and the S... Read More about Alcoholic cardiomyopathy mortality and social vulnerability index: A nationwide cross-sectional analysis..

Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. (2023)
Journal Article
Levis, B., Snell, K. I., Damen, J. A., Hattle, M., Ensor, J., Dhiman, P., …Riley, R. D. (in press). Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed. Journal of Clinical Epidemiology, S0895-4356(23)00282-2. https://doi.org/10.1016/j.jclinepi.2023.10.022

Risk of bias assessments are important in meta-analyses of both aggregate and individual participant data (IPD). There is limited evidence on whether and how risk of bias of included studies or datasets in IPD meta-analyses (IPDMAs) is assessed. We r... Read More about Risk of bias assessments in individual participant data meta-analyses of test accuracy and prediction models: a review shows improvements are needed..

In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. (2023)
Journal Article
Mogas Barcons, A., Chari, D. M., & Adams, C. (in press). In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation. Alternatives to animal experimentation : a journal for new paths in biomedical science / edited by the Swiss Society ALTEX Edition, 41(2), 202-212. https://doi.org/10.14573/altex.2304171

Effective repair of spinal cord injury sites remains a major clinical challenge. One promising strategy is the implantation of multifunctional bioscaffolds to enhance nerve fibre growth, guide regenerating tissue and modulate scarring/inflammation pr... Read More about In vitro model of neurotrauma using the chick embryo to test regenerative bioimplantation..

Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial. (2023)
Journal Article
Velikova, G., Morden, J. P., Haviland, J. S., Emery, C., Barrett-Lee, P., Earl, H., …Cameron, D. (in press). Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial. Lancet Oncology, S1470-2045(23)00460-6. https://doi.org/10.1016/S1470-2045%2823%2900460-6

Adjuvant chemotherapy for patients with early breast cancer improves outcomes but its toxicity affects patients' quality of life (QOL). The UK TACT2 trial investigated whether accelerated epirubicin improves time to recurrence and if oral capecitabin... Read More about Accelerated versus standard epirubicin followed by cyclophosphamide, methotrexate, and fluorouracil or capecitabine as adjuvant therapy for breast cancer (UK TACT2; CRUK/05/19): quality of life results from a multicentre, phase 3, open-label, randomised, controlled trial..

A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool) (2023)
Journal Article
Bailey, D. L., Bishop, A., McCray, G., Foster, N. E., & Holden, M. A. (2023). A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool). British Journal of Sports Medicine, 58(2), bjsports-2022-106347. https://doi.org/10.1136/bjsports-2022-106347

Objectives: This study aimed to (1) develop a new measure of adherence to exercise for musculoskeletal (MSK) pain (Adherence To Exercise for Musculoskeletal Pain Tool: ATEMPT) based on previously conceptualised domains of exercise adherence, (2) repo... Read More about A new measure of exercise adherence: the ATEMPT (Adherence To Exercise for Musculoskeletal Pain Tool).

Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial (2023)
Journal Article
Swaby, L., Perry, D. C., Walker, K., Hind, D., Mills, A., Jayasuriya, R., …Greenwood, S. (2023). Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial. Bone & Joint Open, 4(11), 873-880. https://doi.org/10.1302/2633-1462.411.bjo-2023-0128

Scoliosis is a lateral curvature of the spine with associated rotation, often causing distress due to appearance. For some curves, there is good evidence to support the use of a spinal brace, worn for 20 to 24 hours a day to minimize the curve, makin... Read More about Bracing Adolescent Idiopathic Scoliosis (BASIS) study – night-time versus full-time bracing in adolescent idiopathic scoliosis: study protocol for a multicentre, randomized controlled trial.

Experiences and care needs of children with long Covid: a qualitative study. (2023)
Journal Article
Faux-Nightingale, A., Saunders, B., Burton, C., Chew-Graham, C. A., Somayajula, G., Twohig, H., & Welsh, V. (2023). Experiences and care needs of children with long Covid: a qualitative study. British Journal of General Practice Open (BJGP Open), 8(1), Article 0143. https://doi.org/10.3399/BJGPO.2023.0143

Long Covid, the patient-preferred term, describes symptoms persisting after an acute episode of Covid-19 infection. Symptoms in children and young people (CYP) can affect daily routine, with broader impacts on education, health-related quality of lif... Read More about Experiences and care needs of children with long Covid: a qualitative study..