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All Outputs (4734)

Discrimination of a single-item scale to measure intention to have a COVID-19 vaccine (2025)
Journal Article
Sim, J., Smith, L. E., Amlôt, R., Rubin, G. J., Sevdalis, N., & Sherman, S. M. (2025). Discrimination of a single-item scale to measure intention to have a COVID-19 vaccine. PloS one, 20(5), Article e0322503. https://doi.org/10.1371/journal.pone.0322503

Aim: When developing public health measures in a pandemic, it is important to examine attitudes and beliefs relating to vaccination uptake. We report the discrimination of a single-item vaccination intention scale and derive cutpoints in terms of sen... Read More about Discrimination of a single-item scale to measure intention to have a COVID-19 vaccine.

Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2) (2025)
Journal Article
Geraghty, A. W. A., Becque, T., Roberts, L. C., Hill, J., Foster, N. E., Yardley, L., Stuart, B., Turner, D. A., Griffiths, G., Webley, F., Durcan, L., Morgan, A., Hughes, S., Bathers, S., Butler-Walley, S., Wathall, S., Mansell, G., White, M., Davies, F., & Little, P. (2025). Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2). Health Technology Assessment, 29(7), 1-112. https://doi.org/10.3310/gdps2418

Background Low back pain is highly prevalent and a leading cause of disability. Internet-delivered interventions may provide rapid and scalable support for behavioural self-management. There is a need to determine the effectiveness of highly accessib... Read More about Supporting self-management with an internet intervention for low back pain in primary care: a RCT (SupportBack 2).

Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory (2025)
Journal Article
Rai, T., Hinton, L. E., Mackay, R., Black, M., Sanders, J., Slade, P., Elsmore, A., Dhadda, A., Parry-Smith, W., Collis, R., Petrou, S., Stanworth, S., Pallman, P., Townson, J., Fye, H., Geden, A. G., Collins, P., & Bell, S. (2025). Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory. PloS one, 20(4), Article e0320754. https://doi.org/10.1371/journal.pone.0320754

Background: Post-partum haemorrhage (PPH) is one of the leading causes of maternal mortality and morbidity worldwide. The Obstetric Bleeding Strategy (OBS) care bundle for PPH management was adopted into Welsh national guidelines in 2019 (as OBS Cymr... Read More about Managing obstetric bleeding in Wales: A qualitative evaluation of the OBS Cymru care bundle using Normalisation Process Theory.

Co‐Producing Resources to Help Improve Access to Primary Care for Young People With Attention Deficit Hyperactivity Disorder (2025)
Journal Article
Gudka, R., Salimi, A., Gaywood, R., Hendrick, D., Becker, K., Medzinskii, O., Mughal, F., Melendez‐Torres, G. J., Smith, J., Newlove‐Delgado, T., & Price, A. (2025). Co‐Producing Resources to Help Improve Access to Primary Care for Young People With Attention Deficit Hyperactivity Disorder. Health Expectations, 28(3), Article e70200. https://doi.org/10.1111/hex.70200

Background: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder resulting in negative long‐term outcomes if untreated. Pathways to healthcare in the United Kingdom are complex, especially for those aged 16–25 trans... Read More about Co‐Producing Resources to Help Improve Access to Primary Care for Young People With Attention Deficit Hyperactivity Disorder.

Temporal species stability underpins the link between biodiversity and human health (2025)
Journal Article
Xu, Q., Qu, B., Zhao, P., Clement, S., Shi, Y., Li, L., Jordan, K. P., & Chen, Y. (2025). Temporal species stability underpins the link between biodiversity and human health. Environmental Research, 278(1 August 2025), Article 121728. https://doi.org/10.1016/j.envres.2025.121728

Biodiversity is known to impact human health, but the complex relationships between species diversity and health outcomes is poorly understood. Measuring the temporal dissimilarity in species composition can be leveraged to understand the stability o... Read More about Temporal species stability underpins the link between biodiversity and human health.

Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China (2025)
Journal Article
Qu, B., Hu, B., Rong, R., Wu, L., Shi, X., Ma, Z. F., Yuan, L., Goodacre, R., Jordan, K. P., & Chen, Y. (2025). Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China. BMC Public Health, 25(1), Article 1571. https://doi.org/10.1186/s12889-025-22638-y

Background: The accumulation of heavy metals in surface soil raises significant environmental and public health concerns around the world. This study aimed to examine the relationship between exposure to heavy metals in surface soil and the risk of p... Read More about Regional concentrations of heavy metals in surface soils and risk of body pain in elderly residential population: a national cohort study in China.

Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study (2025)
Journal Article
Ashworth, J., Cornwall, N., Harrisson, S., Woodcock, C., Nicholls, E., Lancaster, G., Wathall, S., Laing, L., Helliwell, T., Jowett, S., Kigozi, J., Mallen, C., Avery, A., Knaggs, R., Pincus, T., White, S., & Jinks, C. (2025). Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study. Pilot and Feasibility Studies, 11(1), Article 53. https://doi.org/10.1186/s40814-025-01636-2

Background: Given the poor long-term effectiveness of opioids for persistent non-cancer pain, and their potential for harm, evidence-based interventions to address opioid overprescribing for persistent pain are needed. This study aimed to explore the... Read More about Proactive clinical review of patients taking opioid medicines long term for persistent pain led by clinical pharmacists in primary care teams (PROMPPT): a non-randomised mixed methods feasibility study.

Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care (2025)
Journal Article
Harrisson, S. A., Jinks, C., Cornwall, N., Woodcock, C., Dikomitis, L., Helliwell, T., Higginbottom, A., Lefroy, J., Knaggs, R., Pincus, T., Santar, M., Sillitto, C., Webb, M., White, S., Mallen, C. D., & Ashworth, J. (2025). Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care. Health Expectations, 28(3), Article e70264. https://doi.org/10.1111/hex.70264

Background: Stakeholder involvement is a core element of the Medical Research Council (MRC) framework for developing and evaluating complex interventions, but approaches to involve stakeholders are not well‐reported. We outline how stakeholders contr... Read More about Stakeholder Involvement in the Development of a New Proactive Clinical Review of Patients Prescribed Opioid Medicines Long‐Term for Persistent Pain in Primary Care.

Experiences and Perceptions of Self‐Harm in Rural‐Dwelling Adults: A Rapid Review of Qualitative Evidence (2025)
Journal Article
Saunders, K., Nicholls, W., Corp, N., Kingstone, T., Mughal, F., Chew‐Graham, C. A., Southam, J., & Fisher, T. (2025). Experiences and Perceptions of Self‐Harm in Rural‐Dwelling Adults: A Rapid Review of Qualitative Evidence. Health Expectations, 28(3), 1-10. https://doi.org/10.1111/hex.70268

Background: Self‐harm is associated with factors that are relevant to and exacerbated by rurality. Living in rural areas may intensify existing socio‐economic disadvantages linked to service access, employment opportunities, transport conditions and... Read More about Experiences and Perceptions of Self‐Harm in Rural‐Dwelling Adults: A Rapid Review of Qualitative Evidence.

Physical Impairments in People With Gout: A Scoping Review (2025)
Journal Article
Kumar, P., Buckley, J., Roddy, E., & Thomas, M. J. (2025). Physical Impairments in People With Gout: A Scoping Review. Musculoskeletal Care, 23(2), 1-28. https://doi.org/10.1002/msc.70103

Introduction: Gout is the most common form of inflammatory arthritis. It is predominantly managed with pharmacological interventions, and physical impairments in people with gout have seldom been studied. We aimed to identify gout‐related physical im... Read More about Physical Impairments in People With Gout: A Scoping Review.

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer (2025)
Journal Article
Chen, L., Wang, C., Chang, J., Shiau, A., Shieh, G., Tseng, Y., Yen, Y., Huang, T., Cheng, L., Wu, Y., Wu, C., Su, B., & Wu, P. (2025). Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer. Molecular Oncology, 1-20. https://doi.org/10.1002/1878-0261.70035

Elevated expression of prothymosin α (ProT) is frequently observed in cancers, but the underlying molecular mechanism remains poorly understood. Here, we report the clinical relevance of ProT expression and its correlation with lung cancer progressio... Read More about Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer.

A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children (2025)
Journal Article
Twohig, H., Franklin, L., Carroll, W., Corp, N., Jackson, E., Mallen, C., Ruan, B., Yapp, L., Van Der Windt, D., & Smith, J. (2025). A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children. Paediatric Respiratory Reviews, 1-37. https://doi.org/10.1016/j.prrv.2025.04.005

Background
Dry powder inhalers (DPIs) are a lower-carbon option than pressurised metered dose inhalers (pMDIs). However, DPIs require a forceful inhalation to achieve good lung deposition and there is uncertainty as to whether younger children can e... Read More about A systematic review of the clinical effectiveness of dry powder inhalers in maintenance treatment and in treatment of acute exacerbations of asthma in children.

Primary Care and Linked Secondary Care Encounters for Foot and Ankle Problems in Children and Young People: A Population‐Based Cohort Study in England (2025)
Journal Article
Rezel‐Potts, E., Bowen, C., Dunn, K. M., Jones, C. I., Gulliford, M. C., & Morrison, S. C. (2025). Primary Care and Linked Secondary Care Encounters for Foot and Ankle Problems in Children and Young People: A Population‐Based Cohort Study in England. Journal of Foot and Ankle Research, 18(2), 1-9. https://doi.org/10.1002/jfa2.70046

Background: In the United Kingdom, foot and ankle problems in children and young people are typically seen by the general practitioner in primary care and referred to secondary care or community services for specialist assessment and intervention. Fo... Read More about Primary Care and Linked Secondary Care Encounters for Foot and Ankle Problems in Children and Young People: A Population‐Based Cohort Study in England.

Assessing ChatGPT 4.0’s Capabilities in the United Kingdom Medical Licensing Examination (UKMLA): A Robust Categorical Analysis (2025)
Journal Article
Casals-Farre, O., Baskaran, R., Singh, A., Kaur, H., Ul Hoque, T., de Almeida, A., Coffey, M., & Hassoulas, A. (in press). Assessing ChatGPT 4.0’s Capabilities in the United Kingdom Medical Licensing Examination (UKMLA): A Robust Categorical Analysis. Scientific Reports, 15(1), Article 13031. https://doi.org/10.1038/s41598-025-97327-2

Advances in the various applications of artificial intelligence will have important implications for medical training and practice. The advances in ChatGPT-4 alongside the introduction of the medical licensing assessment (MLA) provide an opportunity... Read More about Assessing ChatGPT 4.0’s Capabilities in the United Kingdom Medical Licensing Examination (UKMLA): A Robust Categorical Analysis.

JIGSAW-A PROCESS AND FEASIBILITY OF IMPLEMENTING GUIDELINE RECOMMENDATIONS FOR THE CARE OF OSTEOARTHRITIS IN WEST-AFRICA (2025)
Journal Article
Babatunde, O., Adetunji, O., Alonge, I., Owoyemi, T., Ayinmode, E., Ogunbanjo, A., White, S., Adebajo, A., Mallen, C., & Dziedzic, K. (in press). JIGSAW-A PROCESS AND FEASIBILITY OF IMPLEMENTING GUIDELINE RECOMMENDATIONS FOR THE CARE OF OSTEOARTHRITIS IN WEST-AFRICA. BMJ Global Health,

Objectives: To assess the feasibility of a guideline-informed model of care for osteoarthritis in primary healthcare and community pharmacy settings in West-African context.

Methods: 4-phase mixed-methods programme of research undertaken in south-... Read More about JIGSAW-A PROCESS AND FEASIBILITY OF IMPLEMENTING GUIDELINE RECOMMENDATIONS FOR THE CARE OF OSTEOARTHRITIS IN WEST-AFRICA.

Footwear Toe‐Box Shape and Medial Forefoot Pressures in Women With Hallux Valgus (2025)
Journal Article
Bajraszewski, K. J., Lim, P. Q. X., Buldt, A. K., Hurn, S. E., Mickle, K. J., Roddy, E., Wluka, A. E., Erbas, B., Munteanu, S. E., & Menz, H. B. (2025). Footwear Toe‐Box Shape and Medial Forefoot Pressures in Women With Hallux Valgus. Journal of Foot and Ankle Research, 18(2), Article e70041. https://doi.org/10.1002/jfa2.70041

Background: Narrow fitting footwear is a modifiable risk factor for the development of hallux valgus (HV). Despite this, the pressure that footwear exerts at the medial forefoot has not been fully evaluated in people with HV. Therefore, the objective... Read More about Footwear Toe‐Box Shape and Medial Forefoot Pressures in Women With Hallux Valgus.

The accuracy of an electronic-Surprise-Question defining end-of-life cohorts in a whole adult population by algorithmic digital risk stratification: the Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA). (2025)
Journal Article
Singh, B. M., Kumari-Dewat, N., Klaire, V., Lampitt, J., Palmer, A., Ryder, A., Ahmed, K., Sidhu, M., Jennens, H., Viswanath, A., & Parry, E. (2025). The accuracy of an electronic-Surprise-Question defining end-of-life cohorts in a whole adult population by algorithmic digital risk stratification: the Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA). EBioMedicine, 115(May 2025), Article 105682. https://doi.org/10.1016/j.ebiom.2025.105682

Current methods for identifying end-of-life cannot be applied systematically to large populations. We have developed, tested, validated a mortality probability algorithm with that level of scalability. This was a prospective whole adult population co... Read More about The accuracy of an electronic-Surprise-Question defining end-of-life cohorts in a whole adult population by algorithmic digital risk stratification: the Proactive Risk-Based and Data-Driven Assessment of Patients at the End of Life (PRADA)..

Learning latent profiles via cognitive growth charting in psychosis: design and rationale for the PRECOGNITION project (2025)
Journal Article
Marquand, A. F., Bučková, B. R., Cattaranusi, G., Flaaten, C., Busch, C., Lemvigh, C. K., Gupta, V., Fraza, C., Westlye, L. T., Andreassen, O. A., Hlinka, J., Ebdrup, B. H., Shiers, D., Ueland, T., & Dazzan, P. (2025). Learning latent profiles via cognitive growth charting in psychosis: design and rationale for the PRECOGNITION project. Schizophrenia Bulletin, https://doi.org/10.1093/schizbullopen/sgaf007

Background and Hypothesis Cognitive impairments are a core feature of psychosis that are often evident before illness onset and have substantial impact on both clinical and real-world functional outcomes. Therefore, these are an excellent target for... Read More about Learning latent profiles via cognitive growth charting in psychosis: design and rationale for the PRECOGNITION project.