Skip to main content

Research Repository

Advanced Search

All Outputs (380)

Optimizing outcomes for ankylosing spondylitis and axial spondyloarthritis patients: a holistic approach to care. (2018)
Journal Article
(2018). Optimizing outcomes for ankylosing spondylitis and axial spondyloarthritis patients: a holistic approach to care. Rheumatology, vi29 - vi34. https://doi.org/10.1093/rheumatology/key200

Axial SpA (axSpA) can affect diverse elements of an individual's life. The areas affected can be much more wide-ranging than the historical medical model of SpA, causing increased disease activity (pain and stiffness) and disability (reduced range of... Read More about Optimizing outcomes for ankylosing spondylitis and axial spondyloarthritis patients: a holistic approach to care..

The impact of diabetes on the prognostic value of left ventricular function following percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society. (2018)
Journal Article
Mamas, & Rashid. (2018). The impact of diabetes on the prognostic value of left ventricular function following percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society. Catheterization and Cardiovascular Interventions, 393-402. https://doi.org/10.1002/ccd.27642

Objectives To study the relationship between diabetes mellitus (DM) and left ventricular (LV) function on outcomes following percutaneous coronary intervention (PCI). Background Methods DM is a growing public health challenge worldwide and a signific... Read More about The impact of diabetes on the prognostic value of left ventricular function following percutaneous coronary intervention: Insights from the British Cardiovascular Intervention Society..

The Elicitation and Management of Multiple Health Concerns in GP Consultations (2018)
Journal Article
Chew-Graham. (2018). The Elicitation and Management of Multiple Health Concerns in GP Consultations. Patient Education and Counseling, https://doi.org/10.1016/j.pec.2018.11.009

Objective To describe the nature of patient concerns and to explore if, when and how they are addressed by GPs in the UK. Methods Detailed coding and descriptive analysis of 185 video recordings from the EPaC study (Elicitation of Patient Concer... Read More about The Elicitation and Management of Multiple Health Concerns in GP Consultations.

Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies (2018)
Journal Article
Martinengo, L., Olsson, M., Bajpai, R., Soljak, M., Upton, Z., Schmidtchen, A., …Jarbrink, K. (2019). Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies. Annals of Epidemiology, 29, 8 - 15. https://doi.org/10.1016/j.annepidem.2018.10.005

Purpose Chronic wounds are a major public health challenge, but little is known about the true burden with studies reporting different estimates because of disparities in study designs and measurement methods. This hampers efficient resource allocat... Read More about Prevalence of chronic wounds in the general population: systematic review and meta-analysis of observational studies.

Acute flares of knee osteoarthritis in primary care: a feasibility and pilot case-crossover study (2018)
Journal Article
Thomas, M., Butler-Walley, S., Rathod-Mistry, T., Mayson, Z., Parry, E., Pope, C., …Peat, G. (2018). Acute flares of knee osteoarthritis in primary care: a feasibility and pilot case-crossover study. Pilot and Feasibility Studies, 4, Article 167. https://doi.org/10.1186/s40814-018-0359-4

Background: Osteoarthritis (OA) is a leading cause of persistent pain and disability. Traditionally viewed as a slowly progressive disease, the impact of symptom variability on prognosis remains unclear. 'Acute-on-chronic' episodes are a well-recogni... Read More about Acute flares of knee osteoarthritis in primary care: a feasibility and pilot case-crossover study.

Periodic Health Examination and Injury Prediction in Professional Football (Soccer): Theoretically, the Prognosis is Good. (2018)
Journal Article
Van Der Windt. (2018). Periodic Health Examination and Injury Prediction in Professional Football (Soccer): Theoretically, the Prognosis is Good. Sports Medicine, 2443-2448. https://doi.org/10.1007/s40279-018-0928-y

In professional soccer and other elite sports, medical and performance screening of athletes (also termed periodic health examination or PHE) is common practice. The purposes of this are: (1) to assist in identifying prevalent conditions that may be... Read More about Periodic Health Examination and Injury Prediction in Professional Football (Soccer): Theoretically, the Prognosis is Good..

Exploring the Relationship between Examiners’ Memories for performances, domain separation and score variability. (2018)
Journal Article
Yeates, & McCray. (2018). Exploring the Relationship between Examiners’ Memories for performances, domain separation and score variability. Medical Teacher, 1159-1165. https://doi.org/10.1080/0142159X.2018.1463088

Background: OSCE examiners' scores are variable and may discriminate domains of performance poorly. Examiners must hold their observations of OSCE performances in "episodic memory" until performances end. We investigated whether examiners vary in the... Read More about Exploring the Relationship between Examiners’ Memories for performances, domain separation and score variability..

Correction to Lancet Public Health 2018; 3: 567–75 (2018)
Journal Article
Kontopantelis, E., Buchan, I., Webb, R. T., Ashcroft, D. M., Mamas, M. A., & Doran, T. (2018). Correction to Lancet Public Health 2018; 3: 567–75. The Lancet Public Health, 3(12), e566. https://doi.org/10.1016/s2468-2667%2818%2930231-7

Kontopantelis E, Buchan I, Webb RT, Ashcroft DM, Mamas MA, Doran T. Disparities in mortality among 25–44-year-olds in England: a longitudinal population-based study. Lancet Public Health 2018; 3: 567–75—In figure 5 of this Article, the labels on the... Read More about Correction to Lancet Public Health 2018; 3: 567–75.

Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: converging roads to therapeutic development (2018)
Journal Article
Bowerman, M., Murray, L., Scamps, F., Schneider, B., Kothary, R., & Raoul, C. (2018). Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: converging roads to therapeutic development. European Journal of Medical Genetics, 685-698. https://doi.org/10.1016/j.ejmg.2017.12.001

Spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are the two most common motoneuron disorders, which share typical pathological hallmarks while remaining genetically distinct. Indeed, SMA is caused by deletions or mutations in th... Read More about Pathogenic commonalities between spinal muscular atrophy and amyotrophic lateral sclerosis: converging roads to therapeutic development.

Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death (2018)
Journal Article
Morgan, C., Webb, R. T., Carr, M. J., Kontopantelis, E., Chew-Graham, C. A., Kapur, N., & Ashcroft, D. M. (2018). Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death. The Lancet Psychiatry, 905-912. https://doi.org/10.1016/S2215-0366%2818%2930348-1

BACKGROUND: Self-harm is a major risk factor for suicide, with older adults (older than 65 years) having reportedly greater suicidal intent than any other age group. With the aging population rising and paucity of research focus in this age group, th... Read More about Self-harm in a primary care cohort of older people: incidence, clinical management, and risk of suicide and other causes of death.

The use of bioimpedance spectroscopy to guide fluid management in patients receiving dialysis (2018)
Journal Article
Tabinor, M., & Davies, S. (2018). The use of bioimpedance spectroscopy to guide fluid management in patients receiving dialysis. Current Opinion in Nephrology and Hypertension, 27(6), 406-412. https://doi.org/10.1097/MNH.0000000000000445

PURPOSE OF REVIEW To summarize the findings of recent trials and meta-analyses designed to determine whether bioimpedance spectroscopy adds value to the clinical assessment of fluid status in dialysis patients so as to achieve a normally hydrated we... Read More about The use of bioimpedance spectroscopy to guide fluid management in patients receiving dialysis.

The impact of inadequate health literacy in a musculoskeletal pain population (2018)
Journal Article
Lacey, R., Campbell, P., Lewis, M., & Protheroe, J. (2018). The impact of inadequate health literacy in a musculoskeletal pain population. https://doi.org/10.3928/24748307-20181101-01

Musculoskeletal conditions are a major cause of ill-health and disability. Inadequate health literacy may partly explain why musculoskeletal self-management programmes are not effective for some patients. This study prospectively evaluates the impact... Read More about The impact of inadequate health literacy in a musculoskeletal pain population.

One-Year Outcomes after PCI Strategies in Cardiogenic Shock. (2018)
Journal Article
Mamas. (2018). One-Year Outcomes after PCI Strategies in Cardiogenic Shock. New England Journal of Medicine, 1699 - 1710. https://doi.org/10.1056/NEJMoa1808788

BACKGROUND: Among patients with acute myocardial infarction, cardiogenic shock, and multivessel coronary artery disease, the risk of a composite of death from any cause or severe renal failure leading to renal-replacement therapy at 30 days was found... Read More about One-Year Outcomes after PCI Strategies in Cardiogenic Shock..

Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT. (2018)
Journal Article
Chew-Graham. (2018). Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT. Health Technology Assessment, 1 - 136. https://doi.org/10.3310/hta22630

BACKGROUND: Depression is usually managed in primary care and antidepressants are often the first-line treatment, but only half of those treated respond to a single antidepressant. OBJECTIVES: To investigate whether or not combining mirtazapine with... Read More about Combining mirtazapine with SSRIs or SNRIs for treatment-resistant depression: the MIR RCT..

Tobacco and electronic cigarette products: awareness, cessation attitudes, and behaviours among general practitioners (2018)
Journal Article
Rashid, A., Jawad, M., & Mughal, F. (2018). Tobacco and electronic cigarette products: awareness, cessation attitudes, and behaviours among general practitioners. Primary Health Care Research and Development, 605-609. https://doi.org/10.1017/S1463423618000166

Background Little is known around how general practitioners (GP) approach tobacco products beyond traditional cigarettes. Aim To examine GP perceptions of tobacco and electronic cigarette (EC) products, and their attitudes and behaviours towards... Read More about Tobacco and electronic cigarette products: awareness, cessation attitudes, and behaviours among general practitioners.

Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures? (2018)
Journal Article
(2018). Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures?. Statistical Methods in Medical Research, 3505-3522. https://doi.org/10.1177/0962280217705678

If individual participant data are available from multiple studies or clusters, then a prediction model can be externally validated multiple times. This allows the model's discrimination and calibration performance to be examined across different set... Read More about Meta-analysis of prediction model performance across multiple studies: Which scale helps ensure between-study normality for the C-statistic and calibration measures?.

Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR) (2018)
Journal Article
Kessler, D. S., MacNeill, S. J., Tallon, D., Lewis, G., Peters, T. J., Hollingworth, W., …Wiles, N. J. (2018). Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR). BMJ, k4218 - ?. https://doi.org/10.1136/bmj.k4218

OBJECTIVE: To investigate the effectiveness of combining mirtazapine with serotonin-noradrenaline reuptake inhibitor (SNRI) or selective serotonin reuptake inhibitor (SSRI) antidepressants for treatment resistant depression in primary care. DESIGN: T... Read More about Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR).

MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR) (2018)
Journal Article
Chew-Graham. (2018). MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR). BMJ, https://doi.org/10.1136/bmj.k4218

Objective: To investigate the effectiveness of combining mirtazapine with Serotonin-Noradrenaline Reuptake Inhibitor (SNRI) or Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants for patients in primary care who had not responded to an anti... Read More about MIRtazapine added to SSRIs or SNRIs for Treatment Resistant Depression in Primary Care: a placebo controlled randomised trial (MIR).