All Outputs (380)

Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink (2018)
Journal Article
J. Ferguson, R., Prieto‐Alhambra, D., Walker, C., Yu, D., M. Valderas, J., Judge, A., …J. Silman, A. (2019). Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink. Pharmacoepidemiology and Drug Safety, 187-193. https://doi.org/10.1002/pds.4673

PURPOSE: The diagnosis of hip osteoarthritis is subject to several uncertainties, especially in primary care. The aims of this study were to determine (i) the diagnostic accuracy of coding of hip osteoarthritis by primary care physicians in the UK... Read More about Validation of hip osteoarthritis diagnosis recording in the UK Clinical Practice Research Datalink.

The extra-articular impacts of rheumatoid arthritis: moving towards holistic care (2018)
Journal Article
Scott, I., Machin, A., Mallen, C., & Hider, S. (2018). The extra-articular impacts of rheumatoid arthritis: moving towards holistic care. BMC Rheumatology, 2, Article 32. https://doi.org/10.1186/s41927-018-0039-2

Although treat-to-target has revolutionised the outcomes of patients with rheumatoid arthritis (RA) there is emerging evidence that attaining the target of remission is insufficient to normalise patients' quality of life, and ameliorate the extra-art... Read More about The extra-articular impacts of rheumatoid arthritis: moving towards holistic care.

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study (2018)
Journal Article
Mallen, Roddy, Belcher, Clarson, & Muller. (2018). Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study. Arthritis Research and Therapy, 20, Article 243. https://doi.org/10.1186/s13075-018-1746-1

BACKGROUND: An association between gout and renal disease is well-recognised but few studies have examined whether gout is a risk factor for subsequent chronic kidney disease (CKD). Additionally, the impact of urate-lowering therapy (ULT) on developm... Read More about Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study.

Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study. (2018)
Journal Article
Protheroe. (2018). Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study. Disability and Rehabilitation, 1 - 9. https://doi.org/10.1080/09638288.2018.1485182

BACKGROUND: This study recorded the functional health literacy levels of people with musculoskeletal (MSK) conditions from harder to reach groups and explored their experiences in engaging with health care professionals to self-manage their MSK condi... Read More about Self-management of a musculoskeletal condition for people from harder to reach groups: a qualitative patient interview study..

miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA (2018)
Journal Article
Shang, J., He, Q., Chen, Y., Yu, D., Sun, L., Cheng, G., …Zhao, Z. (2019). miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA. Journal of Cellular Physiology, 234(6), 9746-9755. https://doi.org/10.1002/jcp.27660

Long-term peritoneal dialysis (PD) often ends up with ultrafiltration failure (UFF) which is partially caused by persistent inflammation and fibrosis of peritoneal tissues. However, the mechanism is still unclear. In the current study, the peritoneum... Read More about miR-15a-5p suppresses inflammation and fibrosis of peritoneal mesothelial cells induced by peritoneal dialysis via targeting VEGFA.

The humanistic and economic burden of chronic wounds: A systematic review (2018)
Journal Article
Olsson, M., Jarbrink, K., Divakar, U., Bajpai, R., Upton, Z., Schmidtchen, A., & Car, J. (2019). The humanistic and economic burden of chronic wounds: A systematic review. Wound Repair and Regeneration, 27(1), 114 -125. https://doi.org/10.1111/wrr.12683

Chronic wounds are a health problem that have devastating consequences for patients and contribute major costs to healthcare systems and societies. To understand the magnitude of this health issue, a systematic review was undertaken. Searches were co... Read More about The humanistic and economic burden of chronic wounds: A systematic review.

Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice (2018)
Journal Article
Hider, S., Lawton, S., Muller, S., Helliwell, T., Zwierska, I., Mallen, C., & Richardson, J. (2018). Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice. British Journal of General Practice (BJGP), 68(676), E783-E793. https://doi.org/10.3399/bjgp18X699557

BACKGROUND: Polymyalgia rheumatica (PMR) is one of the most common inflammatory arthritic disorders seen in older individuals. Most patients with PMR are diagnosed and managed exclusively in general practice, yet primary care-focused research is lack... Read More about Challenges of diagnosing and managing polymyalgia rheumatica: a multi-methods study in UK general practice.

Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes (2018)
Journal Article
Riley, R. D., Snell, K. I. E., Ensor, J., Burke, D. L., Harrell, F. E., Moons, K. G. M., & Collins, G. S. (2019). Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes. Statistics in Medicine, 38(7), 1276-1296. https://doi.org/10.1002/sim.7992

When designing a study to develop a new prediction model with binary or time-to-event outcomes, researchers should ensure their sample size is adequate in terms of the number of participants (n) and outcome events (E) relative to the number of predic... Read More about Minimum sample size for developing a multivariable prediction model: Part II-binary and time-to-event outcomes.

Effectiveness of health education materials in general practice waiting rooms: a cross-sectional study (2018)
Journal Article
Maskell, K., McDonald, P., & Paudyal, P. (2018). Effectiveness of health education materials in general practice waiting rooms: a cross-sectional study. British Journal of General Practice (BJGP), 68(677), e869-e876. https://doi.org/10.3399/bjgp18x699773

Background Health education materials (HEMs) are widely used in general practice. However, there is little information on the variety of HEMs currently available to patients in the UK, or their preferences for accessing educational materials. Aim... Read More about Effectiveness of health education materials in general practice waiting rooms: a cross-sectional study.

From Taxonomy to Requirements: A Task Space Partitioning Approach (2018)
Presentation / Conference
Elshehaly, M., Alvarado, N., McVey, L., Randell, R., Mamas, M., & Ruddle, R. A. (2018, October). From Taxonomy to Requirements: A Task Space Partitioning Approach. Paper presented at 2018 IEEE Evaluation and Beyond - Methodological Approaches for Visualization (BELIV), Berlin, Germany

The following topics are dealt with: data visualisation; human factors; decision making; data analysis; data aggregation; cognition; inference mechanisms; authoring systems; user experience; social networking (online).

Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study (2018)
Presentation / Conference
Crowley, L., Abdul Sultan, A., Roddy, E., Mallen, C., Protheroe, J., & Clarson, L. (2018, October). Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study. Poster presented at 2018 ACR/ARHP Annual Meeting

Background/Purpose: Evidence is conflicting concerning dementia risk in gout patients, with hyperuricaemia proposed to exert a neuroprotective effect. Serum urate (sUA) targets guiding urate-lowering therapies (ULT) are poorly evidenced-based and th... Read More about Risk of Dementia in Patients with Gout and the Impact of Urate-Lowering Therapies: A Large Population-Based Cohort Study.

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., Edwards, J. J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Objectives The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate two models... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Efficacy of Shoe-Stiffening Inserts for First Metatarsophalangeal Joint Osteoarthritis: Preliminary Findings from the Simple Randomised Controlled Trial (2018)
Presentation / Conference
Munteanu, S., Landorf, K., McClelland, J., Roddy, E., Cicuttini, F., Shiell, A., …Menz, H. B. (2018, October). Efficacy of Shoe-Stiffening Inserts for First Metatarsophalangeal Joint Osteoarthritis: Preliminary Findings from the Simple Randomised Controlled Trial

Background/Purpose: This trial assessed the efficacy of shoe-stiffening inserts for reducing pain associated with first metatarsophalangeal joint (MTPJ) osteoarthritis (OA). Methods: One hundred participants (45 men 55 women, mean age 57.5, SD 10.... Read More about Efficacy of Shoe-Stiffening Inserts for First Metatarsophalangeal Joint Osteoarthritis: Preliminary Findings from the Simple Randomised Controlled Trial.

Inactivated Influenza Vaccine Prevents Respiratory Infections and Improves All-Cause and Cause-Specific Mortality in Immunosuppressed People with Autoimmune Rheumatic Diseases: Propensity Score Adjusted Cohort Study Using Data from Clinical Practice Research Datalink (2018)
Presentation / Conference
Nakafero, G., Grainge, M., Myles, P., Mallen, C., Zhang, W., Doherty, M., …Abhishek, A. (2018, October). Inactivated Influenza Vaccine Prevents Respiratory Infections and Improves All-Cause and Cause-Specific Mortality in Immunosuppressed People with Autoimmune Rheumatic Diseases: Propensity Score Adjusted Cohort Study Using Data from Clinical Practice Research Datalink. Paper presented at 2018 ACR/ARHP Annual Meeting, Chicago, IL, USA

The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. (2018)
Journal Article
Chesterton, L. S., Blagojevic-Bucknall, M., Burton, C., Dziedzic, K. S., Davenport, G., Jowett, S. M., …Roddy, E. (2018). The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial. The Lancet, 392(10156), 1423 - 1433. https://doi.org/10.1016/s0140-6736%2818%2931572-1

Background To our knowledge, the comparative effectiveness of commonly used conservative treatments for carpal tunnel syndrome has not been evaluated previously in primary care. We aimed to compare the clinical and cost-effectiveness of night splint... Read More about The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial..

Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. (2018)
Journal Article
Mallen. (2018). Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol. BMJ Open, e022205 - ?. https://doi.org/10.1136/bmjopen-2018-022205

INTRODUCTION: Neurogenic claudication due to spinal stenosis is common in older adults. The effectiveness of conservative interventions is not known. The aim of the study is to estimate the clinical and cost-effectiveness of a physiotherapist-deliver... Read More about Better Outcomes for Older people with Spinal Trouble (BOOST) Trial: a randomised controlled trial of a combined physical and psychological intervention for older adults with neurogenic claudication, a protocol..

Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink (2018)
Journal Article
Yu, D., Jordan, K. P., Snell, K. I. E., Riley, R. D., Bedson, J., James Edwards, J., …Peat, G. (2018). Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink. Annals of the Rheumatic Diseases, https://doi.org/10.1136/annrheumdis-2018-213894

Abstract Objectives The ability to efficiently and accurately predict future risk of primary total hip and knee replacement (THR/TKR) in earlier stages of osteoarthritis (OA) has potentially important applications. We aimed to develop and validate t... Read More about Development and validation of prediction models to estimate risk of primary total hip and knee replacements using data from the UK: two prospective open cohorts using the UK Clinical Practice Research Datalink.

Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology (2018)
Journal Article
Rutter, A., Crees, J., Wright, H., van Pittius, D., Yousef, I., & Sule-Suso, J. (2018). Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology. Analyst, 5711 - 5717. https://doi.org/10.1039/C8AN01634H

Over the last few years, great effort has been placed on developing Fourier Transform Infrared (FTIR) microspectroscopy as a tool to help in the histopathological diagnosis of cancer. The ever increasing workload in pathology departments is calling f... Read More about Fourier transform infrared spectra of cells on glass coverslips: a further step in spectral pathology.

P064 Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. L., Su, Y. C., Feng, Y. H., Huang, Y. S., Wu, P., & Wu, C. L. (2018, October). P064 Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Paper presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy

Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. . L., Su, Y. . C., Feng, Y. . H., Huang, Y. . S., Wu, P., & Wu, C. . L. (2018, October). Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Poster presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell Research (ISSCR) and the French Society of Gene and Cell Therapy (SFTCG), Lausanne, Switzerland

The elongation of long-chain fatty acids family member 6(Elovl6), a key enzyme in lipogenesis, catalyzes the elongation of saturated and monounsaturated fatty acids. Insulin resistance is associated with upregulation of Elovl6, which has been linkedt... Read More about Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma.