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Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma (2018)
Presentation / Conference
Shiau, A. L., Su, Y. C., Feng, Y. H., Huang, Y. S., Wu, P., & Wu, C. L. (2018, October). Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma. Paper presented at Changing the Face of Modern Medicine: Stem Cell and Gene Therapy Organized Jointly by the European Society of Gene & Cell Therapy (ESGCT), International Society for Stem Cell Research (ISSCR) and the French Society of Gene and Cell Therapy (SFTCG), Lausanne, Switzerland

The Factor IX (FIX) gene therapy (BAX335) was produced in small-scale for hemophilia-B patients in clinical phase I/II. In the course of the internal BAX335 process development, the small-scale clinical product was compared to BAX335 developed using... Read More about Adenovirus-mediated transfer of shRNA against Elovl6 reduces the progression of hepatocellular carcinoma.

Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries (2018)
Journal Article
Lancaster, G. A., McCray, G., Kariger, P., Dua, T., Titman, A., Chandna, J., …Janus, M. (2018). Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries. BMJ Global Health, 3(5), e000747. https://doi.org/10.1136/bmjgh-2018-000747

Background Renewed global commitment to the improvement of early child development outcomes, as evidenced by the focus of the United Nations Sustainable Development Goal 4, highlights an increased need for reliable and valid measures to evaluate prev... Read More about Creation of the WHO Indicators of Infant and Young Child Development (IYCD): metadata synthesis across 10 countries.

Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review (2018)
Journal Article
Dziedzic, K., Holden, M., & Healey, E. L. (2019). Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review. Arthritis Care and Research, 71(2), 237-251. https://doi.org/10.1002/acr.23787

OBJECTIVE To identify and evaluate the measurement properties of self-report physical activity (PA) instruments suitable for those with osteoarthritis (OA). METHODS A comprehensive two-stage systematic review using multiple electronic databases... Read More about Identification and Evaluation of Self-Report Physical Activity Instruments in Adults With Osteoarthritis: A Systematic Review.

Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis (2018)
Journal Article
(2018). Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis. The Lancet Gastroenterology & Hepatology, https://doi.org/10.1016/S2468-1253%2818%2930301-7

Background In patients with rectal cancer who achieve clinical complete response after neoadjuvant chemoradiotherapy, watch and wait is a novel management strategy with potential to avoid major surgery. Study-level meta-analyses have reported wide v... Read More about Factors affecting local regrowth after watch and wait for patients with a clinical complete response following chemoradiotherapy in rectal cancer (InterCoRe consortium): an individual participant data meta-analysis.

Procedural success and outcomes with increasing use of enabling strategies for chronic total occlusion intervention: an analysis of 28,050 cases from the British Cardiovascular Intervention Society database (2018)
Journal Article
Kinnaird, T., Cockburn, J., Sirker, A., Ludman, P., de Belder, M., Smith, E., …Hildick-Smith, D. (2018). Procedural success and outcomes with increasing use of enabling strategies for chronic total occlusion intervention: an analysis of 28,050 cases from the British Cardiovascular Intervention Society database. Circulation: Cardiovascular Interventions, https://doi.org/10.1161/CIRCINTERVENTIONS.118.006436

BACKGROUND Enabling strategies (ESs) are increasingly used during percutaneous coronary intervention for chronic total occlusive disease (CTO-PCI), enhancing procedural success. Using the British Cardiovascular Society dataset, we examined changes i... Read More about Procedural success and outcomes with increasing use of enabling strategies for chronic total occlusion intervention: an analysis of 28,050 cases from the British Cardiovascular Intervention Society database.

Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management (2018)
Journal Article
Marshall, M., Watt, F. E., Vincent, T. L., & Dziedzic, K. (2018). Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management. Nature Reviews Rheumatology, 14, 641-656. https://doi.org/10.1038/s41584-018-0095-4

Osteoarthritis (OA) is a highly prevalent condition and the hand is the most commonly affected site. Patients with hand OA frequently report symptoms of pain, functional limitations, and frustration in undertaking everyday activities. The condition p... Read More about Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management.

Effects of intensive interventions compared to standard care in people with type 2 diabetes and microalbuminuria on risk factors control and cardiovascular outcomes: A systematic review and meta-analysis of randomised controlled trials (2018)
Journal Article
Usman, M., Gillies, C. L., Khunti, K., & Davies, M. J. (2018). Effects of intensive interventions compared to standard care in people with type 2 diabetes and microalbuminuria on risk factors control and cardiovascular outcomes: A systematic review and meta-analysis of randomised controlled trials. Diabetes Research and Clinical Practice, 146, 76-84. https://doi.org/10.1016/j.diabres.2018.10.002

Aims The effect of intensive glycaemic control, blood pressure control and lipid levels control alone or as part of a multifactorial intervention has not been fully evaluated. We aimed to estimate the effects of more intensive interventions, compare... Read More about Effects of intensive interventions compared to standard care in people with type 2 diabetes and microalbuminuria on risk factors control and cardiovascular outcomes: A systematic review and meta-analysis of randomised controlled trials.

Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study (2018)
Journal Article
Partington, R., Muller, S., Helliwell, T., Mallen, C., & Abdul Sultan, A. (2018). Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study. Annals of the Rheumatic Diseases, 77(12), 1750-1756. https://doi.org/10.1136/annrheumdis-2018-213883

Objective Polymyalgia rheumatica (PMR) is the most common inflammatory rheumatic disease in older people. Contemporary estimates of the incidence and prevalence are lacking, and no previous study has assessed treatment patterns at a population level... Read More about Incidence, prevalence and treatment burden of Polymyalgia Rheumatica in the UK over two decades: a population-based study.

Vitamin B3 and Neurodevelopment in Parkinson's Disease (2018)
Presentation / Conference
(2018, October). Vitamin B3 and Neurodevelopment in Parkinson's Disease. Presented at 2018 International Congress, Hong Kong

Vitamin B3 and Neurodevelopment in Parkinson’s Disease A. Williams, S. Griffin, R. Fricker (Birmingham, United Kingdom) Meeting: 2018 International Congress ABSTRACT NUMBER: 592 Keywords: Cell replacement therapy, Dopaminergic neurons Se... Read More about Vitamin B3 and Neurodevelopment in Parkinson's Disease.

Biographical suspension and liminality of Self in accounts of severe sciatica (2018)
Journal Article
Saunders, B., Bartlam, B., Artus, M., & Konstantinou, K. (2018). Biographical suspension and liminality of Self in accounts of severe sciatica. Social Science and Medicine, 218, 28 -36. https://doi.org/10.1016/j.socscimed.2018.10.001

Sciatica is a common form of low back pain (LBP) that has been identified as distinct both in terms of the persistence and severity of symptoms. Little research has explored individual experiences of sciatica, and none focuses on individuals with the... Read More about Biographical suspension and liminality of Self in accounts of severe sciatica.

The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus. (2018)
Journal Article
Duff, C. J., Solis-Trapala, I., Driskell, O. J., Holland, D., Wright, H., Waldron, J. L., …Fryer, A. A. (2018). The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus. Clinical Chemistry and Laboratory Medicine, https://doi.org/10.1515/cclm-2018-0503

Introduction: We previously showed, in patients with diabetes, that >50% of monitoring tests for glycated hemoglobin (HbA1c) are outside recommended intervals and that this is linked to diabetes control. Here, we examined the impact of tests/year on... Read More about The frequency of testing for glycated haemoglobin, HbA1c, is linked to the probability of achieving target levels in patients with suboptimally controlled diabetes mellitus..

Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study (2018)
Journal Article
Mallen. (2018). Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study. Rheumatology, 1726-1734. https://doi.org/10.1093/rheumatology/key156

Objectives To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. Methods From the Clinical Practice Research Datalink, 32 751 people with auto-i... Read More about Predictors and temporal trend of flu vaccination in auto-immune rheumatic diseases in the UK: a nationwide prospective cohort study.

Perioperative supplementation with a fruit and vegetable juice powder concentrate and postsurgical morbidity: a double-blind, randomised, placebo controlled clinical trial (2018)
Journal Article
(2018). Perioperative supplementation with a fruit and vegetable juice powder concentrate and postsurgical morbidity: a double-blind, randomised, placebo controlled clinical trial. Clinical Nutrition, 1448-1455. https://doi.org/10.1016/j.clnu.2017.08.004

Aims Surgical trauma leads to an inflammatory response that causes surgical morbidity. Reduced antioxidant micronutrient (AM)a levels and/or excessive levels of Reactive Oxygen Species (ROS)b have previously been linked to delayed wound healing and... Read More about Perioperative supplementation with a fruit and vegetable juice powder concentrate and postsurgical morbidity: a double-blind, randomised, placebo controlled clinical trial.

Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. (2018)
Journal Article
Chew-Graham. (2018). Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis. JAMA Internal Medicine, 1317 - 1330. https://doi.org/10.1001/jamainternmed.2018.3713

Importance: Physician burnout has taken the form of an epidemic that may affect core domains of health care delivery, including patient safety, quality of care, and patient satisfaction. However, this evidence has not been systematically quantified.... Read More about Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis..

Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink. (2018)
Journal Article
Dunn. (2018). Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink. European Journal of Pain, 1701-1708. https://doi.org/10.1002/ejp.1256

BACKGROUND: One fifth of primary care attendees suffer chronic non-cancer pain, with musculoskeletal conditions the leading cause. 12% of patients with chronic non-cancer pain are prescribed strong opioids. Evidence suggests long-term opioid use is r... Read More about Increased risk of reproductive dysfunction in women prescribed long-term opioids for musculoskeletal pain: a matched cohort study in the Clinical Practice Research Datalink..

Derivation and external validation of risk algorithms for cerebrovascular (re)hospitalisation in patients with type 2 diabetes: two cohorts study. (2018)
Journal Article
Yu. (2018). Derivation and external validation of risk algorithms for cerebrovascular (re)hospitalisation in patients with type 2 diabetes: two cohorts study. Diabetes Research and Clinical Practice, 74-81. https://doi.org/10.1016/j.diabres.2018.08.006

Aims Cerebrovascular disease is one of more typical reasons for hospitalisation and re-hospitalisation in people with type 2 diabetes. We aimed to derive and externally validate two risk prediction algorithms for cerebrovascular hospitalisation and... Read More about Derivation and external validation of risk algorithms for cerebrovascular (re)hospitalisation in patients with type 2 diabetes: two cohorts study..

TCT-658 Complex High and Indicated Percutaneous Coronary Indication: Does Operator Volume Influence Patient Outcome? (2018)
Journal Article
Kinnaird, T., Gallagher, S., Spratt, J., Ludman, P., de Belder, M., de Belder, M., …Mamas, M. (2018). TCT-658 Complex High and Indicated Percutaneous Coronary Indication: Does Operator Volume Influence Patient Outcome?. Journal of the American College of Cardiology, 72(13), B263. https://doi.org/10.1016/j.jacc.2018.08.1867

Background Complex high-risk and indicated revascularisation using percutaneous coronary intervention (CHIP-PCI) is an emerging concept that is poorly studied. Using the British Intervention Society (BCIS) PCI database, we examined temporal changes... Read More about TCT-658 Complex High and Indicated Percutaneous Coronary Indication: Does Operator Volume Influence Patient Outcome?.

Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes (2018)
Journal Article
Mamas. (2018). Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes. JAMA Cardiology, https://doi.org/10.1001/jamacardio.2018.3029

Importance Same-day discharge (SDD) after elective percutaneous coronary intervention (PCI) is associated with lower costs and preferred by patients. However, to our knowledge, contemporary patterns of SDD after elective PCI with respect to the inci... Read More about Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes.