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Diagnostic accuracy of diagnostic imaging for lumbar disc herniation in adults with low back pain or sciatica is unknown; a systematic review (2018)
Journal Article
Kim, J., van Rijn, R. M., van Tulder, M. W., Koes, B. W., de Boer, M. R., Ginai, A. Z., …Verhagen, A. P. (2018). Diagnostic accuracy of diagnostic imaging for lumbar disc herniation in adults with low back pain or sciatica is unknown; a systematic review. Chiropractic & Manual Therapies, 25, Article 37. https://doi.org/10.1186/s12998-018-0207-x

Main text: We aim to summarize the available evidence on the diagnostic accuracy of imaging (index test) compared to surgery (reference test) for identifying lumbar disc herniation (LDH) in adult patients. For this systematic review we searched MEDLI... Read More about Diagnostic accuracy of diagnostic imaging for lumbar disc herniation in adults with low back pain or sciatica is unknown; a systematic review.

Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark: a cross-sectional analysis. (2018)
Journal Article
(2018). Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark: a cross-sectional analysis. BMC Musculoskeletal Disorders, 300. https://doi.org/10.1186/s12891-018-2183-7

BACKGROUND: This study aimed to a) describe the prevalence of knee and hip osteoarthritis risk factors in a population of 29-59 year old individuals, b) estimate the association between persistent knee/hip pain and osteoarthritis risk factors, and c)... Read More about Association of osteoarthritis risk factors with knee and hip pain in a population-based sample of 29-59 year olds in Denmark: a cross-sectional analysis..

Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury (2018)
Journal Article
Watt, F., Corp, N., Kingsbury, S., Frobell, R., Englund, M., Felson, D., …Bierma-Zeinstra, S. (2019). Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury. Osteoarthritis and Cartilage, 27(1), 23-33. https://doi.org/10.1016/j.joca.2018.08.001

Objective There are few guidelines for clinical trials of interventions for prevention of post-traumatic osteoarthritis (PTOA), reflecting challenges in this area. An international multi-disciplinary expert group including patients was convened to g... Read More about Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.

A real-world comparison of effectiveness and safety outcomes between clinical trial eligible and ineligible patients in the British Association of Dermatologists Biologic Interventions Register (BADBIR) (2018)
Conference Proceeding
Mason, K. J. (2018). A real-world comparison of effectiveness and safety outcomes between clinical trial eligible and ineligible patients in the British Association of Dermatologists Biologic Interventions Register (BADBIR).

Background: There is preliminary evidence that psoriasis patients eligible for clinical trials of biologics are not representative of real-world patients. Objectives: To determine whether patients enrolled in BADBIR identified as eligible or ineli... Read More about A real-world comparison of effectiveness and safety outcomes between clinical trial eligible and ineligible patients in the British Association of Dermatologists Biologic Interventions Register (BADBIR).

Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain (2018)
Journal Article
Healey, E. L., Afolabi, E. K., Lewis, M., Edwards, J. J., Jordan, K. P., Finney, A., …Dziedzic, K. S. (2018). Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain. BMC Musculoskeletal Disorders, 19, Article 295. https://doi.org/10.1186/s12891-018-2196-2

Background Osteoarthritis (OA) is a leading cause of pain and disability. NICE OA guidelines (2008) recommend that patients with OA should be offered core treatments in primary care. Assessments of OA management have identified a need to improve pri... Read More about Uptake of the NICE osteoarthritis guidelines in primary care: a survey of older adults with joint pain.

A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. (2018)
Journal Article
Holden, M., Whittle, R., Waterfield, J., Chesterton, L., Cottrell, E., Quicke, J., & Mallen, C. (2019). A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis. Physiotherapy, 105(3), 328 - 337. https://doi.org/10.1016/j.physio.2018.08.003

OBJECTIVE: To explore how physiotherapists currently address analgesic use among patients with hip osteoarthritis, and their beliefs about the acceptability of prescribing for these patients. METHODS: A cross-sectional questionnaire was mailed to 312... Read More about A mixed methods exploration of physiotherapist's approaches to analgesic use among patients with hip osteoarthritis..

ADVERSE HEALTH RISKS IN ADOLESCENTS WITH BACK PAIN (2018)
Presentation / Conference
Williams, C., Kamper, S., Michaleff, Z., Campbell, P., Wiggers, J., Hodder, R., & Dunn, K. (2018, August). ADVERSE HEALTH RISKS IN ADOLESCENTS WITH BACK PAIN. Poster presented at 15th International Congress of Behavioral Medicine

Background Adverse health risk indicators such as substance use and psychological distress are public health priorities for adolescents. They are drivers of long term adverse health and social outcomes. For this reason they are common targets of publ... Read More about ADVERSE HEALTH RISKS IN ADOLESCENTS WITH BACK PAIN.

Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice (2018)
Journal Article
Walter, L. M., Koch, C. E., Betts, C. A., Ahlskog, N., Meijboom, K. E., van Westering, T. L. E., …Bowerman, M. (2018). Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice. Human molecular genetics, 27(20), 3582-3597. https://doi.org/10.1093/hmg/ddy249

Physiology and behaviour are critically dependent on circadian regulation via a core set of clock genes, dysregulation of which leads to metabolic and sleep disturbances. Metabolic and sleep perturbations occur in spinal muscular atrophy (SMA), a neu... Read More about Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice.

Individual participant data meta-analysis of continuous outcomes: A comparison of approaches for specifying and estimating one-stage models (2018)
Journal Article
(2018). Individual participant data meta-analysis of continuous outcomes: A comparison of approaches for specifying and estimating one-stage models. Statistics in Medicine, https://doi.org/10.1002/sim.7930

One-stage individual participant data meta-analysis models should account for within-trial clustering, but it is currently debated how to do this. For continuous outcomes modeled using a linear regression framework, two competing approaches are a str... Read More about Individual participant data meta-analysis of continuous outcomes: A comparison of approaches for specifying and estimating one-stage models.

Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial (2018)
Journal Article
(2018). Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial. Nitric Oxide: Biology and Chemistry, 37 - 44. https://doi.org/10.1016/j.niox.2018.08.004

Chronic hypertension in pregnancy is associated with significant adverse pregnancy outcomes, increasing the risk of pre-eclampsia, fetal growth restriction and preterm birth. Dietary nitrate, abundant in green leafy vegetables and beetroot, is reduce... Read More about Effects of dietary nitrate supplementation, from beetroot juice, on blood pressure in hypertensive pregnant women: A randomised, double-blind, placebo-controlled feasibility trial.

The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study (2018)
Journal Article
Helliwell, T., Hider, S., Mallen, C., & Muller, S. (2018). The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study. Primary Health Care Research and Development, https://doi.org/10.1017/S1463423618000543

Aim To assess the provision of information to, and seeking of, information by patients newly diagnosed with polymyalgia rheumatica (PMR) in primary care. Background Polymyalgia rheumatica (PMR) is an inflammatory rheumatological condition of ol... Read More about The availability of health information to patients with newly diagnosed polymyalgia rheumatica: results from the PMR Cohort study.

Using Routinely Collected Data to Ascertain Concordance With Advance Care Planning Preferences (2018)
Journal Article
Tan, W. S., Bajpai, R., Low, C. K., Ho, A. H. Y., & Car, J. (2018). Using Routinely Collected Data to Ascertain Concordance With Advance Care Planning Preferences. Journal of Pain and Symptom Management, 56(5), 659-666.e2. https://doi.org/10.1016/j.jpainsymman.2018.07.017

Context One of the key outcomes of advance care planning is whether patients had received care that was consistent with their expressed goals and preferences. Objectives The aims of this study were to illustrate the feasibility of using routinel... Read More about Using Routinely Collected Data to Ascertain Concordance With Advance Care Planning Preferences.

Attending away from the body predicts increased physical symptom reports at six months in primary care patients (2018)
Journal Article
Chew-Graham. (2018). Attending away from the body predicts increased physical symptom reports at six months in primary care patients. Journal of Psychosomatic Research, 81 - 88. https://doi.org/10.1016/j.jpsychores.2018.08.002

Objective High symptom reporting (HSR) and medically unexplained symptoms (MUS) are associated with considerable distress, disability, healthcare utilization and costs, but are poorly understood, and current treatments are of limited benefit. Most mo... Read More about Attending away from the body predicts increased physical symptom reports at six months in primary care patients.

Subacute carbon monoxide poisoning presenting as vertigo and fluctuating low frequency hearing loss. (2018)
Journal Article
(2018). Subacute carbon monoxide poisoning presenting as vertigo and fluctuating low frequency hearing loss. Journal of Surgical Case Reports, https://doi.org/10.1093/jscr/rjy205

It is estimated that up to 25 000 UK residents are exposed to small amounts of carbon monoxide (CO) annually. Symptoms of chronic exposure to CO are vague and non-specific and include dizziness and hearing loss. We describe a case of 38-year-old lady... Read More about Subacute carbon monoxide poisoning presenting as vertigo and fluctuating low frequency hearing loss..

P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement (2018)
Journal Article
Nagaraja, V., Generaeux, P., Cohen, M., Suh, W., Alasnag, M., Potts, J., …Research Group, K. C. (2018). P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.p6029

Background: Patients undergoing transcatheter aortic valve replacement (TAVR) are often multi-morbid. Whilst the impact of individual comorbid conditions on clinical outcomes following TAVR have been previously assessed, the impact of more global mea... Read More about P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement.

P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data (2018)
Journal Article
Mohamed, M. O., Kinnaird, T., Kwok, C. S., Rashid, M., Anderson, R., Martin, G., …Mamas, M. A. (2018). P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy563.p4592

Background: Patients presenting with acute coronary syndrome (ACS) represent a heterogeneous population with various risk factors for coronary ischaemia and bleeding. Current ESC guidelines recommend potent dual antiplatelet therapy (DAPT), and cardi... Read More about P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data.

5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study (2018)
Journal Article
Rashid, M., Potts, J., Kwok, C., Mohammed, M., Shoaib, A., Esnsor, J., …Mamas, M. (2018). 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.5258

Background: Non-ST-elevation acute coronary syndromes (NSTEACS) remains most vulnerable phenotype of acute myocardial infarction despite significant improvements in treatment and provision of guideline-recommended care. Coronary angiography (CA) is t... Read More about 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study.

Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population (2018)
Journal Article
Yu. (2018). Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population. Journal of Physical Activity and Health, 600 - 604. https://doi.org/10.1123/jpah.2017-0412

Background Chronic kidney disease is common and brings significant health burden. The purpose of this study was to investigate the relationship between physical activity and kidney function. Methods: This was a cross-sectional study set in the Na... Read More about Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population.