All Outputs (395)

Gout: Is there a role in management for the general practice nurse? (2018)
Journal Article
Finney, A., Viggars, R., & Roddy, E. (2018). Gout: Is there a role in management for the general practice nurse?. Practice Nurse,

This chapter focuses on gout, the most prevalent form of inflammatory arthritis. This chapter informs nurses of the signs, symptoms and treatments for gout. Current guideline recommendations are defined, and the educational needs for healthcare profe... Read More about Gout: Is there a role in management for the general practice nurse?.

Health-related quality of life in gout in primary care: baseline findings from a cohort study (2018)
Journal Article
Roddy, Mallen, Bucknall, Muller, & Hider. (2018). Health-related quality of life in gout in primary care: baseline findings from a cohort study. Seminars in Arthritis and Rheumatism, 61-69. https://doi.org/10.1016/j.semarthrit.2017.12.005

Objectives: To examine gout-related, comorbid, and sociodemographic characteristics associated with generic and disease-specific health-related quality of life (HRQOL) in gout.

Methods: Adults with gout from 20 general practices were mailed a que... Read More about Health-related quality of life in gout in primary care: baseline findings from a cohort study.

Comorbidity clusters in people with gout: an observational cohort study with linked medical record review (2018)
Journal Article
Mallen, Roddy, Bucknall, & Hider. (2018). Comorbidity clusters in people with gout: an observational cohort study with linked medical record review. Rheumatology, 1358-1363. https://doi.org/10.1002/acr.23562

Objective. To investigate how comorbid conditions cluster in patients with gout in a UK primary care population.

Methods. A cross-sectional study was performed using baseline data from a primary-care-based prospective observational cohort of peop... Read More about Comorbidity clusters in people with gout: an observational cohort study with linked medical record review.

P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement (2018)
Journal Article
Nagaraja, V., Generaeux, P., Cohen, M., Suh, W., Alasnag, M., Potts, J., Gunning, M., Nolan, J., Bagur, R., Mamas, M., & Research Group, K. C. (2018). P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.p6029

Background: Patients undergoing transcatheter aortic valve replacement (TAVR) are often multi-morbid. Whilst the impact of individual comorbid conditions on clinical outcomes following TAVR have been previously assessed, the impact of more global mea... Read More about P6029Impact of elixhauser comorbidity score on the outcomes of transcatheter aortic valve replacement.

Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population (2018)
Journal Article
Yu. (2018). Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population. Journal of Physical Activity and Health, 600 - 604. https://doi.org/10.1123/jpah.2017-0412

Background
Chronic kidney disease is common and brings significant health burden. The purpose of this study was to investigate the relationship between physical activity and kidney function.

Methods: This was a cross-sectional study set in the Na... Read More about Walking, But Not Other Physical Activity at a Higher Intensity, Is Associated With Improved Kidney Function: A Cross-Sectional Health Survey of General Adult Population.

Effect of Low Back Pain Risk-Stratification Strategy on Patient Outcomes and Care Processes: the MATCH Randomized Trial in Primary Care (2018)
Journal Article
Cherkin, D., Balderson, B., Wellman, R., Hsu, C., Sherman, K., Evers, S., Hawkes, R., Cook, A., Levine, M., Piekara, D., Rock, P., Estlin, K., Brewer, G., Jensen, M., LaPorte, A.-M., Yeoman, J., Sowden, G., Hill, J., & Foster, N. (2018). Effect of Low Back Pain Risk-Stratification Strategy on Patient Outcomes and Care Processes: the MATCH Randomized Trial in Primary Care. Journal of General Internal Medicine, 1324-1336. https://doi.org/10.1007/s11606-018-4468-9

BACKGROUND: The STarT Back strategy for categorizing and treating patients with low back pain (LBP) improved patients' function while reducing costs in England. OBJECTIVE: This trial evaluated the effect of implementing an adaptation of this approach... Read More about Effect of Low Back Pain Risk-Stratification Strategy on Patient Outcomes and Care Processes: the MATCH Randomized Trial in Primary Care.

5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study (2018)
Journal Article
Rashid, M., Potts, J., Kwok, C., Mohammed, M., Shoaib, A., Esnsor, J., Ayyaz-Ul-Haq, M., Nolan, J., & Mamas, M. (2018). 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study. European Heart Journal, 39(suppl_1), https://doi.org/10.1093/eurheartj/ehy566.5258

Background: Non-ST-elevation acute coronary syndromes (NSTEACS) remains most vulnerable phenotype of acute myocardial infarction despite significant improvements in treatment and provision of guideline-recommended care. Coronary angiography (CA) is t... Read More about 5258Trends and outcomes of use of coronary angiography in management of non-ST-Elevation acute coronary syndromes (NSTEACS), a population based cohort study.

P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data (2018)
Presentation / Conference Contribution
Mohamed, M. O., Kinnaird, T., Kwok, C. S., Rashid, M., Anderson, R., Martin, G., Zaman, A., & Mamas, M. A. P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data

Background: Patients presenting with acute coronary syndrome (ACS) represent a heterogeneous population with various risk factors for coronary ischaemia and bleeding. Current ESC guidelines recommend potent dual antiplatelet therapy (DAPT), and cardi... Read More about P4592Trends in prognosis and management of acute coronary syndromes using combined bleeding and ischaemic risk assessment - a retrospective analysis of MINAP data.

Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan. (2018)
Journal Article
(2018). Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan. European Journal of Heart Failure, 1179 - 1190. https://doi.org/10.1002/ejhf.1210

AIMS: Prognostic models for hospitalized heart failure (HHF) were developed predominantly for patients of European origin in the United States of America; it is unclear whether they perform similarly in other health care systems or for different ethn... Read More about Validation of U.S. mortality prediction models for hospitalized heart failure in the United Kingdom and Japan..

Bereavement and loss support for adults with learning disabilities: An exploratory study using Photovoice (2018)
Thesis
Tajuria, G. Bereavement and loss support for adults with learning disabilities: An exploratory study using Photovoice. (Thesis). Keele University. https://keele-repository.worktribe.com/output/411462

Background: Loss and bereavement are devastating life experiences for all human beings belonging to any social group, and adults with learning disabilities are not exempt from the effects of loss. Recent research has shown that adults with learning d... Read More about Bereavement and loss support for adults with learning disabilities: An exploratory study using Photovoice.

Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC) (2018)
Journal Article
Williams, N. H., Jenkins, A., Goulden, N., Hoare, Z., Hughes, D. A., Wood, E., Foster, N. E., Walsh, D., Carnes, D., Sparkes, V., Hay, E. M., Isaacs, J., Konstantinou, K., Morrissey, D., Karppinen, J., Genevay, S., & Wilkinson, C. (2018). Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC). Trials, 19, Article 408. https://doi.org/10.1186/s13063-018-2801-6

BACKGROUND: Adalimumab, a biological treatment targeting tumour necrosis factor a, might be useful in sciatica. This paper describes the challenges faced when developing a new treatment pathway for a randomised controlled trial of adalimumab for peop... Read More about Lessons learnt from a discontinued randomised controlled trial: adalimumab injection compared with placebo for patients receiving physiotherapy treatment for sciatica (Subcutaneous Injection of Adalimumab Trial compared with Control: SCIATiC).

A randomised controlled trial is not a pilot trial simply because it uses a surrogate endpoint. (2018)
Journal Article
(2018). A randomised controlled trial is not a pilot trial simply because it uses a surrogate endpoint. Pilot and Feasibility Studies, 130 - ?. https://doi.org/10.1186/s40814-018-0324-2

Background: It has been argued that true endpoints (or 'hard' endpoints) for clinical trials, which are meaningful to clinicians, researchers and patients alike, are limited to those that measure health status, survival and cost. Other endpoints are... Read More about A randomised controlled trial is not a pilot trial simply because it uses a surrogate endpoint..

Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke (2018)
Journal Article
Barlas, R. S., Loke, Y. K., Mamas, M. A., Bettencourt-Silva, J. H., Ford, I., Clark, A. B., Bowles, K. M., Metcalf, A. K., Potter, J. F., & Myint, P. K. (2018). Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke. American Journal of Cardiology, 122(6), 1085-1090. https://doi.org/10.1016/j.amjcard.2018.05.043

The optimal regimen of antiplatelet therapy for secondary prevention in noncardioembolic ischemic stroke remains controversial. We aimed to determine which regimen was associated with the greatest reduction in adverse outcomes. We analysed prospectiv... Read More about Effect of Antiplatelet Therapy (Aspirin + Dipyridamole Versus Clopidogrel) on Mortality Outcome in Ischemic Stroke.

Cumulative exposure to biological therapy and risk of cancer in patients with psoriasis: a meta-analysis of Psonet studies from Israel, Italy, Spain, the U.K. and Republic of Ireland (2018)
Journal Article
Garcia-Doval, I., Descalzo, M., Mason, K., Cohen, A., Ormerod, A., Gómez-García, F., Cazzaniga, S., Feldhamer, I., Ali, H., Herrera-Acosta, E., Griffiths, C., Stern, R., Naldi, L., & Network, T. P. (2018). Cumulative exposure to biological therapy and risk of cancer in patients with psoriasis: a meta-analysis of Psonet studies from Israel, Italy, Spain, the U.K. and Republic of Ireland. British Journal of Dermatology, 179(4), 863-871. https://doi.org/10.1111/bjd.16715

Background
Cancer risk following long‐term exposure to systemic immunomodulatory therapies in patients with psoriasis is possible.

Objectives
To assess a dose–response relationship between cumulative length of exposure to biological therapy and... Read More about Cumulative exposure to biological therapy and risk of cancer in patients with psoriasis: a meta-analysis of Psonet studies from Israel, Italy, Spain, the U.K. and Republic of Ireland.

Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients (2018)
Journal Article
Yu. (2018). Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients. Kidney and Blood Pressure Research, https://doi.org/10.1159/000492048

Background/Aims:
Cerebrovascular disease (CeVD) is one of the leading causes of death in patients initialising peritoneal dialysis (PD). Currently there is no risk score to predict the future risk of CeVD on entry into PD. This study aimed to derive... Read More about Derivation and Validation of Risk Scores to Predict Cerebrovascular Mortality Among Incident Peritoneal Dialysis Patients.

Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs) (2018)
Presentation / Conference Contribution
Hulme, C., Wilson, E., Fuller, H., Roberts, S., Richardson, J., Gallacher, P., Peffers, M., Shirran, S., Botting, C., & Wright, K. (2018, July). Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs). Poster presented at Matrix Biology Europe – July 2018 Meeting Celebrating 50 years of Federation of European Connective Tissue Societies Meetings, Manchester, United Kingdom

Introduction: Autologous chondrocyte implantation (ACI) is a cell therapy used to treat cartilage defects and early osteoarthritis. During initial surgery (Stage I), healthy cartilage is harvested from the joint. Chondrocytes are isolated and culture... Read More about Identification of synovial fluid proteins that are associated with early osteoarthritis treatment failure: the search for novel markers leads us back to matrix metalloproteinases (MMPs).

Justifications for using complementary and alternative medicine reported by persons with musculoskeletal conditions: A narrative literature synthesis (2018)
Journal Article
Corp, N., Jordan, J. L., & Croft, P. R. (2018). Justifications for using complementary and alternative medicine reported by persons with musculoskeletal conditions: A narrative literature synthesis. PloS one, 13(7), Article e0200879. https://doi.org/10.1371/journal.pone.0200879

BACKGROUND: Complementary and alternative medicine (CAM) is very popular with patients frequently combining it with orthodox health care. The high prevalence of CAM use and satisfaction with CAM reported by patients directly challenges an orthodox sy... Read More about Justifications for using complementary and alternative medicine reported by persons with musculoskeletal conditions: A narrative literature synthesis.

A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol (2018)
Journal Article
Paskins, Z., Hughes, G., Myers, H., Hughes, E., Hennings, S., Cherrington, A., Evans, A., Holden, M., Stevenson, K., Menon, A., Bromley, K., Roberts, P., Hall, A., Peat, G., Jinks, C., Oppong, R., Lewis, M., Foster, N. E., Mallen, C., & Roddy, E. (2018). A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol. BMC Musculoskeletal Disorders, 19, Article 218. https://doi.org/10.1186/s12891-018-2153-0

BACKGROUND: Evidence on the effectiveness of intra-articular corticosteroid injection for hip osteoarthritis is limited and conflicting. The primary objective of the Hip Injection Trial (HIT) is to compare pain intensity over 6 months, in people with... Read More about A randomised controlled trial of the clinical and cost-effectiveness of ultrasound-guided intra-articular corticosteroid and local anaesthetic injections: the hip injection trial (HIT) protocol.

How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial (2018)
Journal Article
Chew-Graham. (2018). How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial. BMC Family Practice, 116 -?. https://doi.org/10.1186/s12875-018-0813-7

BACKGROUND: Depression in older people may have a prevalence as high as 20%, and is associated with physical co-morbidities, loss, and loneliness. It is associated with poorer health outcomes and reduced quality of life, and is under-diagnosed and un... Read More about How should we implement collaborative care for older people with depression? A qualitative study using normalisation process theory within the CASPER plus trial.

Pilot trials in physical activity journals: a review of reporting and editorial policy (2018)
Journal Article
(2018). Pilot trials in physical activity journals: a review of reporting and editorial policy. Pilot and Feasibility Studies, 125. https://doi.org/10.1186/s40814-018-0317-1

Background: Since the early 2000s, a number of publications in the medical literature have highlighted inadequacies in the design, conduct and reporting of pilot trials. This work led to two notable publications in 2016: a conceptual framework for de... Read More about Pilot trials in physical activity journals: a review of reporting and editorial policy.