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All Outputs (630)

Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis (2021)
Thesis
Echrish, J. H. J. (2021). Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis. (Thesis). Keele University

Coronary heart disease is the primary global cause of morbidity and mortality, accounting for about 33% of global deaths in 2013. Atherosclerosis is the principal cause of coronary heart disease and is caused by inflammation of the arterial wall. Thi... Read More about Developing a 3D tissue-engineered model to study the biology and treatment of atherosclerosis.

Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells (2021)
Thesis
Hyland, M. (2021). Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells. (Thesis). Keele University

Rheumatoid Arthritis (RA) is a chronic autoimmune disease which is characterised by a loss of immune tolerance, and an infiltration of immune cells into joints causing inflammation. Current pharmaceutical treatments for RA have adverse side effects a... Read More about Investigating the characteristics and functions of extracellular vesicles from umbilical cord mesenchymal stem cells.

Rehabilitation following rotator cuff repair: Multi-centre pilot and feasibility randomised controlled trial (RaCeR) (2021)
Journal Article
Littlewood, C., Bateman, M., Butler-Walley, S., Bathers, S., Cookson, T., Bromley, K., …Foster, N. (2021). Rehabilitation following rotator cuff repair: Multi-centre pilot and feasibility randomised controlled trial (RaCeR). Physiotherapy, 113(S1), e13-e14. https://doi.org/10.1016/j.physio.2021.10.238

Purpose: Shoulder pain is a highly prevalent complaint and disorders of the rotator cuff, including tears, are thought to be the most common cause. The number of operations to repair the torn rotator cuff has risen significantly in recent years. Whil... Read More about Rehabilitation following rotator cuff repair: Multi-centre pilot and feasibility randomised controlled trial (RaCeR).

Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study (2021)
Thesis
Barnett, L. A. (2021). Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study. (Thesis). Keele University

Background: Giant cell arteritis (GCA) is the most common form of medium and large vessel vasculitis. This condition is associated with serious complications, such as blindness if left untreated, and is therefore considered a medical emergency. Howev... Read More about Clinical features presented to primary care prior to diagnosis of giant cell arteritis: an electronic health records study.

Students’ Experiences of Peer Observed Teaching: A Qualitative Interview Study (2021)
Journal Article
Rees. (2021). Students’ Experiences of Peer Observed Teaching: A Qualitative Interview Study. Teaching and Learning in Medicine, https://doi.org/10.1080/10401334.2021.2006665

Purpose: To summarise and appraise evidence on the prognosis and long-term clinical and socio-economic outcomes following wrist fracture among adults aged 50 years and over. Methods: Five databases (MEDLINE, EMBASE, AMED, CINAHL-P and PsycINFO) we... Read More about Students’ Experiences of Peer Observed Teaching: A Qualitative Interview Study.

Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (the PACE MSK trial) (2021)
Journal Article
(2021). Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (the PACE MSK trial). BMJ Open, https://doi.org/10.1136/bmjopen-2021-057705

Introduction Musculoskeletal (MSK) conditions constitute the highest burden of disease globally, with healthcare services often utilised inappropriately and overburdened. The aim of this trial is to evaluate the effectiveness of a novel clinical PAth... Read More about Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (the PACE MSK trial).

European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. (2021)
Journal Article
Meattini, I., Becherini, C., Boersma, L., Kaidar-Person, O., Nader Marta, G., Montero, A., …Coles, C. E. (2022). European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer. Lancet Oncology, 23(1), e21 - e31. https://doi.org/10.1016/S1470-2045%2821%2900539-8

High-quality randomised clinical trials testing moderately fractionated breast radiotherapy have clearly shown that local control and survival is at least as effective as with 2 Gy daily fractions with similar or reduced normal tissue toxicity. Fewer... Read More about European Society for Radiotherapy and Oncology Advisory Committee in Radiation Oncology Practice consensus recommendations on patient selection and dose and fractionation for external beam radiotherapy in early breast cancer..

The impact of COVID-19 on primary care: insights from the National Health Service (NHS) and future recommendations (2021)
Journal Article
Mallen, C., Khunti, K., & Mughal, F. (2021). The impact of COVID-19 on primary care: insights from the National Health Service (NHS) and future recommendations. Journal of Family Medicine and Primary Care, 4345-4349. https://doi.org/10.4103/jfmpc.jfmpc_756_21

COVID-19 has changed health systems and services. In this commentary, we outline the impact COVID-19 has had on the delivery of primary health care, and on primary care teams, and describe the NHS response. We highlight the challenges of managing lon... Read More about The impact of COVID-19 on primary care: insights from the National Health Service (NHS) and future recommendations.

New developments in osteoarthritis pharmacological therapies. (2021)
Journal Article
(2021). New developments in osteoarthritis pharmacological therapies. Rheumatology, vi1 - vi11. https://doi.org/10.1093/rheumatology/keab679

OA is an increasingly common, painful condition with complex aetiology and limited therapies. Approaches to expanding our therapeutic armamentarium have included repurposing existing therapies used for other rheumatological conditions, modifying exis... Read More about New developments in osteoarthritis pharmacological therapies..

Evaluating the clinical decision making of physiotherapists in the assessment and management of paediatric shoulder instability (2021)
Journal Article
Philp, F., Faux-Nightingale, A., Woolley, S., de Quincey, E., & Pandyan, A. (2022). Evaluating the clinical decision making of physiotherapists in the assessment and management of paediatric shoulder instability. Physiotherapy, 115, 46-57. https://doi.org/10.1016/j.physio.2021.12.330

Objective To elicit what information and clinical decision-making processes physiotherapists use in the assessment and management of paediatric shoulder instability. Design Qualitative study. A modified nominal focus group technique, involving thr... Read More about Evaluating the clinical decision making of physiotherapists in the assessment and management of paediatric shoulder instability.

THERAPEUTIC EFFECTS OF HYPOXIC AND PRO-INFLAMMATORY PRIMING OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES IN INFLAMMATORY ARTHRITIS (2021)
Journal Article
Kay, A. G., Treadwell, K., Roach, P., Morgan, R., Lodge, R., Hyland, M., …Kehoe, O. (in press). THERAPEUTIC EFFECTS OF HYPOXIC AND PRO-INFLAMMATORY PRIMING OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES IN INFLAMMATORY ARTHRITIS. International Journal of Molecular Sciences, 23(1), Article 126. https://doi.org/10.3390/ijms23010126

AbstractNovel biological therapies have revolutionised the management of Rheumatoid Arthritis (RA) but no cure currently exists. Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion... Read More about THERAPEUTIC EFFECTS OF HYPOXIC AND PRO-INFLAMMATORY PRIMING OF MESENCHYMAL STEM CELL-DERIVED EXTRACELLULAR VESICLES IN INFLAMMATORY ARTHRITIS.

Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis (2021)
Journal Article
Kay, A. G., Roach, P., Morgan, R., Lodge, R., Hyland, M., Piccinini, A. M., …Treadwell, K. (2021). Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis. International Journal of Molecular Sciences, 23(1), 126 - 126. https://doi.org/10.3390/ijms23010126

Mesenchymal stem cells (MSCs) immunomodulate inflammatory responses through paracrine signalling, including via secretion of extracellular vesicles (EVs) in the cell secretome. We evaluated the therapeutic potential of MSCs-derived small EVs in an an... Read More about Therapeutic Effects of Hypoxic and Pro-Inflammatory Priming of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Inflammatory Arthritis.

Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique (2021)
Journal Article
Bateman, M., Saunders, B., Littlewood, C., & Hill, J. (2021). Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique. BMJ Open, 11(12), Article e053841. https://doi.org/10.1136/bmjopen-2021-053841

OBJECTIVES: There are a wide range of physiotherapy treatment options for people with lateral elbow tendinopathy (LET); however, previous studies have reported inconsistent approaches to treatment and a lack of evidence demonstrating clinical effecti... Read More about Development of an optimised physiotherapist-led treatment protocol for lateral elbow tendinopathy: a consensus study using an online nominal group technique.

Emotional distress, anxiety and depression in South Asians with long-term conditions: a qualitative systematic review (2021)
Journal Article
Awan, H., Mughal, F., Kingstone, T., Chew-Graham, C., & Corp, N. (2022). Emotional distress, anxiety and depression in South Asians with long-term conditions: a qualitative systematic review. British Journal of General Practice (BJGP), 72(716), https://doi.org/10.3399/BJGP.2021.0345

Background: People with physical-mental comorbidity have a poorer quality of life, worse clinical outcomes and increased mortality compared to people with physical conditions alone. South Asians (SAs) are the largest minority group in the UK and a... Read More about Emotional distress, anxiety and depression in South Asians with long-term conditions: a qualitative systematic review.

Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021)
Journal Article
Gilchrist, F. J., Green, J., & Carroll, W. (2021). Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, https://doi.org/10.1002/14651858.CD012798.pub3

BACKGROUND: Cystic fibrosis is the most common life-limiting autosomal recessive genetic disorder in white populations. Distal intestinal obstruction syndrome (DIOS) is an important morbidity in cystic fibrosis. It is the result of the accumulation o... Read More about Interventions for treating distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.

Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis (2021)
Journal Article
Carroll, W., Green, J., & Gilchrist, F. J. (in press). Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis. Cochrane Database of Systematic Reviews, 2021(12), https://doi.org/10.1002/14651858.cd012619.pub3

Background Cystic fibrosis (CF) is the most common, life‐limiting, genetically inherited disease. It affects multiple organs, particularly the respiratory system. However, gastrointestinal problems such as constipation and distal intestinal obstruct... Read More about Interventions for preventing distal intestinal obstruction syndrome (DIOS) in cystic fibrosis.

Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. (2021)
Journal Article
Mamas. (2021). Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study. https://doi.org/10.1016/j.jaccao.2021.11.001

Background: Myocardial infarction is a cardiac adverse event associated with 5-fluorouracil (5-FU). There are limited data on the incidence, risk, and prognosis of 5-FU-associated myocardial infarction. Objectives: The aim of this study was to examin... Read More about Risk for Myocardial Infarction Following 5-Fluorouracil Treatment in Patients With Gastrointestinal Cancer: A Nationwide Registry-Based Study..